Pulmonary Vasculature Redox Signaling in Health and Disease

The main goal of this book is to form a high-quality platform in which well-known and emerging pioneering basic, translational and clinical scientists can present their latest, exciting findings in the studies of redox signaling in the pulmonary vasculature. Content from outstanding investigators with unique expertise and skills of molecular and cell biology, biochemistry, physiology, pharmacology, biophysics, biotechnology and medicine will update our current out-of-date concepts with new knowledge. Rapidly increasing scientific studies have gathered a large volume of novel and important information on redox signaling in healthy and diseased pulmonary vasculature. This volume covers the need for a cohesive book to display state-of-the-art advances in the field. The second major aim of this book is to help direct future research. Redox signaling is a major molecular process involved in almost every physiologic cellular response in the pulmonary vasculature including energy metabolism, host defense, gene expression, contraction, proliferation, and migration. Aberrancy in this important signaling pathway leads to a critical role in the development of nearly all pulmonary diseases, such as pulmonary hypertension, cor pulmonale, pulmonary edema, and vasculitis, among others. Front Matter ....Pages i-xxi Adventitial Fibroblast Nox4 Expression and ROS Signaling in Pulmonary Arterial Hypertension (Scott A. Barman, David Fulton)....Pages 1-11 Role of Transcription Factors in Pulmonary Artery Smooth Muscle Cells: An Important Link to Hypoxic Pulmonary Hypertension (Annarita Di Mise, Yong-Xiao Wang, Yun-Min Zheng)....Pages 13-32 Molecular Basis of Nitrative Stress in the Pathogenesis of Pulmonary Hypertension (Colin E. Evans, You-Yang Zhao)....Pages 33-45 Pentose Shunt, Glucose-6-Phosphate Dehydrogenase, NADPH Redox, and Stem Cells in Pulmonary Hypertension (Ryota Hashimoto, Sachin Gupte)....Pages 47-55 Redox Regulation of the Superoxide Dismutases SOD3 and SOD2 in the Pulmonary Circulation (Daniel Hernandez-Saavedra, Kalin Swain, Rubin Tuder, Steen V. Petersen, Eva Nozik-Grayck)....Pages 57-70 A Brief Overview of Nitric Oxide and Reactive Oxygen Species Signaling in Hypoxia-Induced Pulmonary Hypertension (Ariel Jaitovich, David Jourd’heuil)....Pages 71-81 Altered Redox Balance in the Development of Chronic Hypoxia-induced Pulmonary Hypertension (Nikki L. Jernigan, Thomas C. Resta, Laura V. Gonzalez Bosc)....Pages 83-103 ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) (Manuela Kellner, Satish Noonepalle, Qing Lu, Anup Srivastava, Evgeny Zemskov, Stephen M. Black)....Pages 105-137 Redox-Dependent Calpain Signaling in Airway and Pulmonary Vascular Remodeling in COPD (Laszlo Kovacs, Yunchao Su)....Pages 139-160 Natural Antioxidants as Potential Therapy, and a Promising Role for Melatonin Against Pulmonary Hypertension (Gerald J. Maarman)....Pages 161-178 Effects of Hyperoxia on the Developing Airway and Pulmonary Vasculature (Christina M. Pabelick, Michael A. Thompson, Rodney D. Britt Jr)....Pages 179-194 Lung Ischaemia–Reperfusion Injury: The Role of Reactive Oxygen Species (Oleg Pak, Akylbek Sydykov, Djuro Kosanovic, Ralph T. Schermuly, Alexander Dietrich, Katrin Schröder et al.)....Pages 195-225 Redox Mechanisms Influencing cGMP Signaling in Pulmonary Vascular Physiology and Pathophysiology (Dhara Patel, Anand Lakhkar, Michael S. Wolin)....Pages 227-240 Metabolic Reprogramming and Redox Signaling in Pulmonary Hypertension (Lydie Plecitá-Hlavatá, Angelo D’alessandro, Karim El Kasmi, Min Li, Hui Zhang, Petr Ježek et al.)....Pages 241-260 Hydrogen Sulfide as an O2 Sensor: A Critical Analysis (Jesus Prieto-Lloret, Philip I. Aaronson)....Pages 261-276 Redox Signaling and Persistent Pulmonary Hypertension of the Newborn (Megha Sharma, Adeleye J. Afolayan)....Pages 277-287 Cross Talk Between Mitochondrial Reactive Oxygen Species and Sarcoplasmic Reticulum Calcium in Pulmonary Arterial Smooth Muscle Cells (Tengyao Song, Yun-Min Zheng, Yong-Xiao Wang)....Pages 289-298 Endothelial Cell Reactive Oxygen Species and Ca2+ Signaling in Pulmonary Hypertension (Karthik Suresh, Larissa A. Shimoda)....Pages 299-314 Redox Signaling in the Right Ventricle (Yuichiro J. Suzuki, Nataliia V. Shults)....Pages 315-323 Hypoxia and Local Inflammation in Pulmonary Artery Structure and Function (Michael Thompson, Rodney D. Britt Jr., Christina M. Pabelick, Y. S. Prakash)....Pages 325-334 From Physiological Redox Signalling to Oxidant Stress (Jeremy P. T. Ward)....Pages 335-342 Emerging Role of MicroRNAs and Long Noncoding RNAs in Healthy and Diseased Lung (Jun-Hua Xiao, Qiong-Yu Hao, Katie Wang, Jes Paul, Yong-Xiao Wang)....Pages 343-359 Techniques for Detecting Reactive Oxygen Species in Pulmonary Vasculature Redox Signaling (Yi Xu, Steven Qian)....Pages 361-372 Mitochondrial and Metabolic Drivers of Pulmonary Vascular Endothelial Dysfunction in Pulmonary Hypertension (Qiujun Yu, Stephen Y. Chan)....Pages 373-383 Subcellular Redox Signaling (Liping Zhu, Yankai Lu, Jiwei Zhang, Qinghua Hu)....Pages 385-398 Reactive Oxygen Species in COPD-Related Vascular Remodeling (Li Zuo, Chia-Chen Chuang, Alexander D. Clark, Davis E. Garrison, Jamie L. Kuhlman, David C. Sypert)....Pages 399-411 Back Matter ....Pages 413-422