Psoriasis, Second Edition

This 2nd new edition of a concise yet thorough illustrated review of the diagnosis and treatment of many forms of psoriasis now includes the many new therapies available and in development, as well as more material on psoriasis as a systemic disease and on comorbidities. This will be of interest to all dermatologists in training and practice, as well as primary care physicians. Extramammary Paget's Disease -- Guttate Psoriasis -- Pityriasis Rosea -- Pityriasis Versicolor -- Secondary Syphilis -- Pityriasis Lichenoides -- Mycosis Fungoides -- Erythrodermic Psoriasis -- Pityriasis Rubra Pilaris -- Allergic Contact Dermatitis -- Atopic Dermatitis -- Chronic Actinic Dermatitis -- Cutaneous T-cell Lymphoma (sezary Syndrome) -- Drug Eruption -- Pustular Psoriasis -- Acute Generalized Exanthematous Pustulosis -- Drug Eruption -- Tinea Pedis -- Flexural Psoriasis -- Intertrigo -- Candidosis -- Erythrasma -- Tinea Cruris -- Contact Dermatitis -- Hailey-hailey Disease -- Scalp Psoriasis -- Contact Dermatitis -- Atopic Dermatitis -- Seborrheic Dermatitis -- Nail Psoriasis -- Onychomycosis -- Lichen Planus -- Alopecia Areata -- Contact Dermatitis -- Palmoplantar Psoriasis -- Pityriasis Rubra Pilaris -- Tinea Pedis -- Contact Dermatitis -- Acrokeratosis Neoplastica (bazex Syndrome) -- Lichen Planus -- Darier's Disease -- Porokeratosis of Mibelli -- Juvenile Plantar Dermatosis -- Genital Psoriasis -- Seborrheic Dermatitis -- Contact Dermatitis -- Lichen Planus -- Lichen Sclerosus -- Plasma Cell Balanitis (zoon's Balanitits, Balanitis Circumscripta Plasmacellularis) -- Plasma Cell Vulvitis (vulvitis Circumscripta Plasmacellularis) -- Bowen's Disease -- Erythroplasia of Queyrat -- Extramammary Paget's Disease -- External Ear Psoriasis -- Seborrheic Dermatitis -- Atopic Dermatitis -- Contact Dermatitis -- Otitis Externa -- Facial Psoriasis -- Seborrheic Dermatitis -- Lupus Erythematosus -- Contact Dermatitis -- Atopic Dermatitis -- Rosacea -- Final Comments/conclusion -- References -- Chapter 13: Genetics, Immunology, and Pathogenesis -- Epidemiology -- Etiology -- Genetic Susceptibility -- Environmental Factors -- Risk Factors in Patients with Skin Psoriasis -- Immunology -- Cellular Involvement -- Inflammatory Cytokines -- Other Mediators Immunohistopathology -- Pathogenesis -- Summary -- References -- Chapter 14: Psoriatic Arthritis: Clinical Manifestations -- Introduction -- Clinical Concepts -- Clinical Manifestations -- Types of Arthropathy -- Pauciarthritis -- Polyarthritis -- Dip Disease -- Axial Disease -- Arthritis Mutilians -- Enthesitis -- Dactylitis -- Other Clinical Features -- Conclusion -- References -- Chapter 15: Pediatric Psoriasis -- Epidemiology -- Clinical Presentation -- Comorbidities -- Obesity and Cardiovascular Risk -- Joint Complaints -- Other Complaints -- Screening for Comorbidities -- Therapeutic Options -- Topical Therapy (see Chapter 21) -- Phototherapy (see Chapter 22) -- Systemic Therapy (see Chapters 23 and 24) -- References -- Chapter 16: Cardiometabolic Comorbidities -- Cardiometabolic Diseases: Overview -- Obesity -- Dysglycemia -- Dyslipidemia -- Atherosclerotic Cardiovascular Diseases -- The Role of Inflammation in Cardiometabolic Diseases -- Chronic Systemic Inflammation in Psoriasis -- Skin Inflammation -- Blood Inflammation -- Adipose Inflammation -- Vascular Inflammation -- Psoriasis and Cardiovascular Diseases -- Epidemiological Studies -- Translational Studies -- Psoriasis, Obesity and Diabetes -- Epidemiological Studies -- Translational Studies -- Psoriasis Treatment and Effect on Cardiometabolic Diseases -- Epidemiological Studies -- Ongoing Studies -- Recommendation for Screening and Treatment of Cardiometabolic Diseases in Psoriasis -- Conclusions -- References -- Chapter 17: Psychiatric Comorbidities -- Introduction -- Psychosocial Stress -- Anxiety and Social Phobia -- Depression -- Suicidal Ideation -- Alexithymia -- Substance Use -- Alcohol -- Smoking -- Sexual Dysfunction -- Schizophrenia -- Obsessive-Compulsive Disorder -- Personality Disorders -- Somatization and Somatoform Disorders -- Eating Disorders -- Conclusion -- References Chapter 18: Other Disease Associations: Liver, Gastrointestinal, Respiratory, and Neoplastic -- Introduction -- Gastrointestinal Comorbidity -- Inflammatory Bowel Disease -- Epidemiological Correlation -- Genetic Correlations -- Pathologic Correlations -- Celiac Disease -- Microscopic Colitis -- Alterations in Intestinal Structure and Permeability -- Liver -- Nonalcoholic Fatty Liver Disease -- Cholangitis and Cholestasis -- Psoriasis and Lung Comorbidity -- Infectious Pneumonia -- Interstitial Lung Disease -- Pulmonary Fibrosis -- Chronic Obstructive Pulmonary Disease -- Pulmonary Hypertension -- Acute Respiratory Distress Syndrome -- Psoriasis and Cancer -- Conclusions -- References -- Chapter 19: Assessment and Measurement of Disease -- Introduction -- Assessment in Day-to-day Practice -- The Importance of Thorough Measurement and Assessment -- Body Surface Area: a Misunderstood Variable of Assessment -- Clinician-assessed Measurement Tools -- Psoriasis Area and Severity Index -- Physician's Global Assessment -- Psoriasis Subtypes -- Nonplaque Psoriasis Subtypes -- Psoriatic Arthritis -- Patient-report Measurement Tools -- Psoriasis-specific Tools -- Psoriasis Disability Index -- Psoriasis Life Stress Inventory -- Psoriasis Index of Quality of Life -- General Dermatologic and Generic Hrqol Assessment Tools -- Dermatology Life Quality Index -- Skindex -- Short-form 36 -- Combined Measurement Tools -- Salford Psoriasis Index -- Koo-menter Psoriasis Instrument -- The Comprehensive Assessment of the Psoriasis Patient: a Comprehensive Measurement Tool -- References -- Chapter 20: Current and future Topical Treatments for Psoriasis -- Introduction -- Topical Corticosteroids -- Vitamin D Analogs -- Tazarotene -- Calcineurin Inhibitors -- Anthralin/dithranol -- Coal Tar -- Salicylic Acid -- Novel Therapies -- Wbi-1001 -- E804 -- Crisaborole -- Inc8018424 Cover -- Half Title Page -- Title Page -- Copyright Page -- Contents -- Preface -- Contributors -- Chapter 1: The History of Psoriasis -- Biblical Times -- First Century A.D. -- The Renaissance Period -- Evolution of Modern Therapies -- Biological Agents -- Conclusion -- References -- Chapter 2: Epidemiology -- Introduction -- Incidence of Psoriasis -- Prevalence of Psoriasis -- Effects of Ethnicity -- Gender -- Age -- Future Directions -- References -- Chapter 3: Microscopic Findings -- The "Evolution" of Psoriasis -- Chronic Plaque Psoriasis -- Guttate Psoriasis -- Erythrodermic Psoriasis -- Follicular Psoriasis -- Inverse Psoriasis -- Nail Psoriasis -- Pustular Psoriasis -- Palmoplantar Pustulosis -- Antitumor Necrosis Factor Alphainduced Psoriasis -- Verrucous Psoriasis -- Psoriatic Alopecia -- References -- Chapter 4: Genetics -- Introduction -- Mode of Inheritance -- Psoriasis Susceptibility Locus 1 -- Variants Driving Psoriasis Gwas Signals -- Protein Coding Alterations Associated with Psoriasis -- Pathways to Psoriasis Identified through Gwas -- Alterations of Components of the Epidermal Barrier in Psoriasis -- Genes of the Epidermal Differentiation Complex -- CARD14 -- Generalized Pustular Psoriasis -- Rare Variants Leading to Psoriasis -- Genetic Contribution to Disease Severity and Age at Onset -- Conclusion -- Acknowledgments -- References -- Chapter 5: Immunology -- Introduction -- T Cells in Psoriasis -- Integral Role of T Cells in Psoriasis Pathogenesis -- T Cells in Normal Skin -- T Cells in Psoriatic Lesion -- Regulatory T Cells -- Dendritic Cells Interplaying with T cells -- Dermal Myeloid Dendritic Cells -- Plasmacytoid Dendritic Cells -- Langerhans Cells -- Innate Immune Cells in Psoriasis -- Neutrophils -- Macrophages -- Natural Killer and NKT Cells -- Psoriatic Cytokines -- IL-17 -- IL-23 -- IFN-[gamma] -- TNF-[alpha] Immune Pathway Models of Psoriasis -- Conclusions -- References -- Chapter 6: Other environmental risk factors -- Infection -- Medication -- Psychological Distress -- Cigarette Smoking -- Sunshine -- Alcohol Misuse -- Trauma -- References -- Chapter 7: Plaque-Type Psoriasis-Chronic Plaque, Guttate, and Erythrodermic Phenotypes -- Plaque-Type Psoriasis -- Introduction -- Chronic Plaque Psoriasis -- Clinical Symptoms -- Guttate Psoriasis -- Erythrodermic Psoriasis -- References -- Chapter 8: Palmoplantar psoriasis -- Localized Pustular Psoriasis -- Palmoplantar Pustular Psoriasis -- Acrodermatitis Continua of Hallopeau -- Palmoplantar Plaque Psoriasis -- Introduction -- Epidemiology -- Etiopathogenesis -- Clinical Presentation -- Dermatopathology -- Differential Diagnosis -- Treatment -- Summary -- References -- Chapter 9: Generalized Pustular Psoriasis -- Introduction -- Definition, Clinical Presentation, Histopathological, and Biological Findings -- Epidemiology -- Physiopathology -- Clinical Course, Complications, Prognosis -- Treatment -- Conclusion -- References -- Chapter 10: Inverse Psoriasis and Genital Disease -- Clinical Presentation -- Genital Psoriasis -- Differential Diagnoses -- Immunopathology -- Treatment of Inverse and Genital Psoriasis -- Conclusion -- References -- Chapter 11: Nail Psoriasis -- Introduction -- Epidemiology and Prevalence -- Quality of Life -- Clinical Features of Nail Psoriasis -- Assessment of Nail Psoriasis Severity -- Management of Nail Psoriasis -- References -- Chapter 12: Differential Diagnoses of Psoriasis -- Introduction -- Chronic Plaque Psoriasis -- Tinea Corporis -- Discoid Eczema -- Mycosis Fungoides -- Subacute Cutaneous Lupus Erythematosis -- Lichen Planus -- Localised Plaque Psoriasis -- Superficial Basal Cell Carcinoma -- Bowen's Disease -- Contact Dermatitis -- Actinic Keratosis Content: The history of psoriasis. Epidemiology. Microscopic findings. Genetics. Immunology. Other environmental risk factors. Plaque type psoriasis: Chronic plaque, guttate, and erythrodermic phenotypes. Palmoplantar psoriasis. Generalised pustular psoriasis. Inverse psoriasis and genital disease. Nail psoriasis. Differential diagnoses of psoriasis. Genetics, immunology, and pathogenesis. Psoriatic arthritis: Clinical manifestations. Pediatric psoriasis. Cardiometabolic comorbidities. Psychiatric comorbidities. Other disease associations: Liver, gastrointestinal, respiratory, and neoplastic. Assessment and measurement of disease. Current and future topical treatments for psoriasis. Phototherapy and photochemotherapy.Traditional systemic therapies and monitoring guidelines. Current biologic therapies (including IL-17) and monitoring guidelines. Current and future oral small molecules. Biologic therapies in the pipeline. Future directions and personalized medicine. Conclusion. Preceded by Psoriasis / Alan Menter, Benjamin Stoff. c2011. The new edition of a concise yet thorough illustrated review of the diagnosis and treatment of many forms of psoriasis now includes the many new therapies available and in development, as well as more material on psoriasis as a systemic disease and on comorbidities. This will be of interest to all dermatologists in training and practice, as well as primary care physicians