Psoriasis

This is a concise yet thorough review of the diagnosis and treatment of many forms of psoriasis and covers current concepts in the ever-expanding field of psoriasis pathophysiology. Emerging concerns, such as systemic disease associations, quality of life, and psoriatic arthritis, are discussed, plus recent advances in basic science and clinical trial data. The book is of interest to all physicians with an interest in inflammatory skin diseases with systemic associations, including dermatologists in training and practice, candidates for post-registration qualifications, primary care physicians, emergency physicians, and senior medical students. MuPDF error: syntax error: invalid key in dict MuPDF error: syntax error: invalid key in dict MuPDF error: syntax error: invalid key in dict MuPDF error: syntax error: invalid key in dict MuPDF error: syntax error: invalid key in dict MuPDF error: syntax error: invalid key in dict MuPDF error: syntax error: invalid key in dict MuPDF error: syntax error: invalid key in dict MuPDF error: syntax error: invalid key in dict Contents 4 Preface 6 1 HISTORY, EPIDEMIOLOGY, AND PATHOGENESIS 8 The history of psoriasis 8 Epidemiology 12 Pathogenesis: introduction 13 Histology 13 Genetics 15 Immunology 17 2 CLINICAL MANIFESTATIONS OF PSORIASIS 26 Nonpustular psoriasis (plaque type) 26 Clinical photographs 27 Psoriatic plaques 27 Localized nonpustular psoriasis 29 Generalized nonpustular psoriasis 44 Pustular psoriasis 27 Clinical photographs 47 Localized pustular psoriasis 47 Generalized pustular psoriasis 51 Other descriptors 27 Clinical photographs 51 Nail disease 51 Small versus large plaques 54 Stable versus unstable disease 55 3 DIFFERENTIAL DIAGNOSIS 58 Inflammatory skin disease 59 Clinical photographs 60 Eczema 60 Pityriasis rosea 62 Pityriasis rubra pilaris 63 Infectious disorders 65 Clinical photographs 66 Dermatophyte infection 66 Candida 69 Secondary syphilis 69 Neoplasms 71 Clinical photographs 71 Squamous cell carinoma in situ 71 Cutaneous T-cell lymphoma 72 4 PSORIATIC ARTHRITIS 74 General description 74 Epidemiology 74 Genetics, immunology, and pathogenesis 75 Clinical manifestations 75 Prognosis 81 Conclusion 81 5 THERAPY 82 Measuring disease 82 Therapeutic options 82 1 Topical therapy 83 2 Phototherapy and PUVA 87 3 Traditional systemic therapy 92 4 Biologics 99 Combination, rotational, and sequential regimens 109 Future directions 114 6 EFFECTS OF PSORIASIS ON QUALITY OF LIFE 116 Physical impairment 116 Psychosocial impairment 117 Assessment tools 117 Conclusion 119 7 PSORIASIS AS A SYSTEMIC DISEASE 120 Cardiovascular disease 120 Metabolic disorders 121 Gastrointestinal disease 122 Neurological disorders 124 Neoplastic disease 124 Psychiatric disorders 124 Mortality 125 Conclusion 125 8 APPENDIX 126 Assessment tools 126 Abbreviations 136 References 137 Clinician and patient resources 156 Index 157 A 157 B 157 C 157 D 157 E 157 F 157 G 157 H 158 I 158 J 158 K 158 L 158 M 158 N 158 O 159 P 159 Q 159 R 159 S 159 T 160 U 160 V 160 W 160 This is a concise yet thorough Review the diagnosis and treatment of many forms of psoriasis and covers current concepts in the ever-expanding field of psoriasis pathophysiology. Emerging concerns, such as systemic disease associations, quality of life, and psoriatic arthritis, are discussed, plus recent advances in basic science and clinical trial data. The book will appeal to physicians with an interest in inflammatory skin diseases with systemic associations, including dermatologists in training and practice, candidates for post-registration qualifications, primary care physicians, emergenc This text provides a review of the diagnosis and treatment of many forms of psoriasis and covers current concepts in the ever-expanding field of psoriasis pathophysiology. Emerging concerns, such as systemic disease associations, quality of life and psoriatic arthritis are discussed, as well as advances in clinical trial data A concise yet thorough review of the diagnosis and treatment of many forms of psoriasis covering current concepts in the ever-expanding field of psoriasis pathophysiology.