Proteolysis and physiological regulation : proceedings of the Miami Winter Symposia, January 1976, sponsored by the Department of Biochemistry, University of Miami School of Medicine, Miami, Florida

Miami Winter Symposia, Volume 11: Proteolysis and Physiological Regulation contains the proceedings of the University of Miami's Biochemistry Department Symposium on "Proteolysis and Physiological Regulation", which is published simultaneously with the proceedings of the Papanicolaou Cancer Research Institute's Symposium on "Cancer Enzymology" (Volume 12). This volume is composed of 35 chapters and begins with surveys of the structural properties and role of various enzymes in biological regulation. The subsequent chapters describe the structure-activity relationship, cellular production, selectivity, mechanisms, and substrate specificity of the enzymes. Other chapters explore the activation, regulation, biosynthesis, and other biological activities of other enzymes. The remaining chapters discuss property modification, metabolism, binding, and other biological aspects of enzymes. This book will prove useful to enzyme scientists, cell biologists, biochemists, and researchers. Content: MIAMI WINTER SYMPOSIA , Page ii Front Matter , Page iii Copyright , Page iv SPEAKERS, CHAIRMEN, AND DISCUSSANTS , Pages xi-xiii PREFACE , Pages xv-xvi , D.W. Ribbons, K. Brew MY LIFE WITH PROTEINS AND PROSTHETIC GROUPS , Pages 1-27 , Hugo Theorell THE ROLE OF PROTEASES IN BIOLOGICAL REGULATION , Pages 29-42 , H. NEURATH, K.A. WALSH STRUCTURAL STUDIES ON THE PANCREATIC TRYPSIN INHIBITOR – TRYPSIN COMPLEX AND ITS FREE COMPONENTS: STRUCTURE AND FUNCTION RELATIONSHIP IN SERINE PROTEASE INHIBITION AND CATALYSIS , Pages 43-76 , W. Bode, P. Schwager, R. Huber THE PROTEOLYTIC ENZYMES OF THE K-1 STRAIN OF STREPTOMYCES GRISEUS OBTAINED FROM A COMMERCIAL PREPARATION (PRONASE). XI. EVOLUTIONARY IMPLICATIONS , Pages 77-91 , W.M. AWAD JR., K. BREW, J.T. POWELL, D.J. RUSSIN, J.F. SEBER, S. SIEGEL, K.D. VOSBECK RELATIONSHIPS BETWEEN THE STRUCTURES AND ACTIVITIES OF SOME MICROBIAL SERINE PROTEASES. I. PURIFICATION, ENZYMIC PROPERTIES AND PRIMARY STRUCUTRES OF STREPTOMYCES GRISEUS PROTEASES A, B AND TRYPSIN , Pages 93-123 , L. JURASEK, R.W. OLAFSON, P. JOHNSON, LAWRENCE B. SMILLIE RELATIONSHIP BETWEEN THE STRUCTURES AND ACTIVITIES OF SOME MICROBIAL SERINE PROTEASES. II. COMPARISON OF THE TERTIARY STRUCTURES OF MICROBIAL AND PANCREATIC SERINE PROTEASES , Pages 125-142 , MICHAEL N.G. JAMES BIOLOGICAL FUNCTIONS OF ACTIVATED COMPLEMENT PROTEINS IN NORMAL AND DISEASE STATES , Pages 143-165 , DUANE R. SCHULTZ THE NATURE AND REACTIONS OF COMPLEMENT ENZYMES , Pages 167-187 , N.R. Cooper, R.J. Ziccardi SERINE PROTEASES OF COAGULATION AND THEIR INHIBITORS , Pages 189-202 , E.W. DAVIE, K. FUJIKAWA, K. KURACHI, T. KOIDE, W. KISIEL HOMOLOGOUS “KRINGLE” STRUCTURES COMMON TO PLASMINOGEN AND PROTHROMBIN. SUBSTRATE SPECIFICITY OF ENZYMES ACTIVATING PROTHROMBIN AND PLASMINOGEN , Pages 203-238 , S. MAGNUSSON, L. SOTTRUP-JENSEN, T.E. PETERSEN, G. DUDEK-WOJCIECHOWSKA, H. CLAEYS FIBRIN FORMATION AND DISSOLUTION , Pages 239-261 , PATRICK A. McKEE PROTEASES PRODUCED BY NORMAL AND MALIGNANT CELLS IN CULTURE , Pages 263-285 , Daniel B. Rifkin, Robert Pollack THE ROLE OF LYSOSOMES IN PROTEIN TURNOVER , Pages 287-311 , H.L. SEGAL, G.A. DUNAWAY Jr., J.R. WINKLER STUDIES OF THE SELECTIVITY AND MECHANISMS OF INTRACELLULAR PROTEIN DEGRADATION , Pages 313-337 , ALFRED L. GOLDBERG, JOEL D. KOWIT, JOSEPH D. ETLINGER THE ROLE OF NEUTRAL AND ACID PROTEINASES IN CONNECTIVE TISSUE TURNOVER , Pages 339-355 , J.T. Dingle PROTEOLYTIC CONTROL OF COLLAGEN BREAKDOWN , Pages 357-369 , J. Frederick Woessner Jr. SUBSTRATE SPECIFICITY IN PINOCYTOSIS AND INTRALYSOSOMAL PROTEIN DIGESTION , Pages 371-389 , J.B. LLOYD ACTIVATION OF CUTICLE CHITINASE: A PROBABLE NEW INSTANCE OF ACTIVATION BY PARTIAL PROTEOLYSIS , Page 391 , M.L. Bade, A. Stinson Effects of Added Nucleophiles on the Cathepsin B1 Catalyzed Hydrolysis of CBZ-L-Lysine p-Nitrophenyl Ester. Evidence for an Acyl Enzyme Intermediate and Leaving Group Specificity , Page 392 , Andrew S. Bajkowski, Allen Frankfater REGULATION OF THE LEUKOCYTE PROTEINASES BY THE HUMAN PLASMA PROTEINASE INHIBITORS , Page 393 , R.J. Baugh, D.L. Garner, D.A. Johnson, J. Travis AN ESTIMATION OF THE DISTANCE FROM THE ACTIVE SITE TO THE CALCIUM BINDING SITE IN TRYPSIN , Page 394 , D.W. Darnall, E.R. Birnbaum, F. Abbott, J. Gomez, F. Eidson, B. Garcia NATURAL AND SYNTHETIC PEPTIDE INHIBITORS OF PEPSIN , Page 395 , Ben M. Dunn FURTHER EVIDENCE FOR A PROTON PUMP IN PHAGOLYSOSOMES AND THE INVOLVEMENT OF LYSOSOMES IN PROTEIN TURNOVER , Page 396 , R.M. Farb, J.L. Mego INTRACELLULAR CYSTEINE PROTEASES FROM BOVINE LIVER , Page 397 , S.S. Husain CHARGE RELAY OF SERINE PROTEINASES: NMR STUDIES OF FREE AND INHIBITED FORMS OF TRYPSIN AND CHYMOTRYPSIN , Page 398 , I.B. Ibañez, M.A. Porubcan, J.L. Markley MODIFICATION OF THE PROPERTIES OF TRYPSIN BY COVALENT ATTACHMENT OF POLYSACCHARIDE , Page 399 , J. John Marshall, Mark L. Rabinowitz AUTOCATALYTIC ACTIVATION OF Cls , Page 400 , Paul H. Morgan, Indira G. Nair VITAMIN K – DEPENDENT SYNTHESIS AND MODIFICATION OF PRECURSOR PROTHROMBIN IN CULTURED LIVER CELLS , Page 401 , Theodore W. Munns, Robert E. Olson ON THE SPECIFICITIES OF PROTEASES IN THE HEALING HUMAN BURN WOUND , Page 402 , J.D. Ogle, P. Nathan, E.J. Law, B.G. MacMillan PROTEIN METABOLISM IN FETAL RAT LIVER FROM CHRONIC ALCOHOLIC MOTHERS. , Page 403 , A.K. Rawat NEUTRAL AND ACID METALLOPROTEINASES IN HUMAN ARTICULAR CARTILAGE WHICH DEGRADE PROTEOGLYCAN , Page 404 , Asher I. Sapolsky, J. Frederick Woessner Jr., David S. Howell PROTEINASES AND PROTEINASE INHIBITORS IN FERTILIZATION , Page 405 , W.D. Schleuning, H. Schiessler, E. Fink, H. Fritz, H. Tschesche CHARACTERISATION OF ELASTASE AND CHYMOTRYPSIN FROM HUMAN GRANULOCYTE LYSOSOMES , Page 406 , W. Schmidt, K. Havemann THERMODYNAMICS OF SUBSTRATE ANALOG BINDING TO NATIVE AND MODIFIED FORMS OF α-CHYMOTRYPSIN; A STUDY IN “PRODUCTIVE” AND NON-PRODUCTIVE BINDING , Page 407 , R.M. Schultz, A. Konovessi-Panayotatos INHIBITION OF LETHALITY IN ENDOTOXIN CHALLENGED MICE TREATED WITH ZINC CHLORIDE , Page 408 , S.L. Snyder, R.I. Walker RELATIONSHIP BETWEEN ZINC CONTENT AND TRYPSIN BINDING ACTIVITY OF ALPHA 2, -MACROGLOBULIN , Page 409 , M.K. Song, N.F. Adham, H. Rinderknecht MEASUREMENT OF RAT PROTEIN METABOLISM IN VIVO , Page 410 , T. PETER STEIN, Jeffrey C. Oram-Smith, Maria J. Leskiw, Herbert W. Wallace, Linda C. Long, Johnnie M. Leonard