Proteoglycans in Lung Disease (Lung Biology in Health and Disease)

Discusses new treatment strategies for malignant mesothelioma, pulmonary edema, fibrosis, asthma, emphysema, and bronchiectasis.Proteoglycans in Lung Disease considersglycosaminoglycans as novel therapeutic agents or targets in lung disease the role of proteoglycans in determining mechanical behavior of lung tissue hyaluronan and its receptors in wound healing, inflammation, vasculogenesis, and angiogenesis the impact of small proteoglycans on matrix assembly versican as a modulator of cell adhesion, migration, and proliferation antiproliferative activity of heparin and its derivatives on pulmonary artery smooth muscle cells the effects of mechanical strain on proteoglycans the functions of proteoglycans in the vascular wall the effect of hypoxia on glycosaminoglycans in the lung Comprised of more than 1940 references, Proteoglycans in Lung Disease INTRODUCTION......Page 12 PREFACE......Page 15 CONTRIBUTORS......Page 19 CONTENTS......Page 23 Proteoglycans of the Lung......Page 31 Hyaluronan in Lung Function......Page 53 Morphological Tools for Studying Lung Proteoglycans......Page 67 Proteoglycans, Lung Physiology, and Mechanical Strain......Page 85 Hyaluronan and Its Receptors in Lung Health and Disease......Page 103 Hyaluronan and Hyaladherin Signaling in the Lung......Page 137 Hyaluronan in Malignant Mesothelioma......Page 165 Matrix Proteoglycans in Development of Pulmonary Edema......Page 173 The Role of Small Proteoglycans in the Formation of Fibrosis......Page 199 Versican in the Cell Biology of Pulmonary Fibrosis......Page 221 Decorin in Asthma......Page 243 Role of Proteoglycans in the Development and Pathogenesis of Emphysema......Page 271 Proteoglycans in Normal and Pathological Bronchial Mucus......Page 299 Vascular Proteoglycans......Page 321 Degradation of Lung Matrix Proteoglycans in Bronchiectasis......Page 353 Effect of Hypoxia on Glycosaminoglycan Synthesis by Lung Cells......Page 365 Integrins, Proteoglycans, and Lung Disease......Page 381 Heparin as a Potential Therapeutic Agent to Reverse Vascular Remodeling......Page 407 AUTHOR INDEX......Page 429 SUBJECT INDEX......Page 485 The lung is a complex organ consisting of multiple cell and tissue types, and one therefore expects many proteoglycans to be present. This text discusses treatment strategies for malignant mesothelioma, pulmonary oedema, fibrosis, asthma, emphysema and bronchiectasis