Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes (Drugs and the Pharmaceutical Sciences)

Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is an invaluable source for drug discovery and development scientists in the biopharmaceutical industry who frequently navigate the maze of protein and peptide pharmacokinetics, pharmacodynamics, and metabolism. Key features include: In vitro/in vivo correlations of pharmacokinetics, pharmacodynamics, and metabolism for hematologic growth factors and cytokines / Graham Molineux and Stephen J. Szilvassy In vitro-in vivo correlations of pharmacokinetics, pharmacodynamics, and metabolism for antibody therapeutics / C. Andrew Boswell ... [et al.] In vitro/in vivo correlations of pharmacokinetics, pharmacodynamics, and metabolism for extracellular matrix-binding growth factors / Mathew A. Nugent, Maria Mitsi, and Jean L. Spencer Metabolic processes at injection sites affecting pharmacokinetics, pharmacodynamics, and metabolism of protein and peptide therapeutics / Randall J. Mrsny Local tissue responses to polymer implants affecting pharmacokinetics, pharmacodynamics, and metabolism of proteins and peptides / James M. Anderson and William G. Brodbeck Engineering as a means to improve the pharmacokinetics of injected therapeutic proteins / Mark S. Dennis ... [et al.] Ophthalmic delivery of protein and peptide therapeutics : pharmacokinetics, pharmacodynamics, and metabolism considerations / Arto Urtti Pharmacokinetic and pharmacodynamic aspects of intranasal delivery / Henry R. Costantino ... [et al.] Oral delivery of protein and peptide therapeutics : PK/PD considerations / Puchun Liu and Steven Dinh Drug interaction studies of therapeutic biologics : protein and peptide actions and interactions that alter their pharmacokinetics, pharmacodynamics, and metabolism / Iftekhar Mahmood Intersection of pharmacogenetics with pharmacokinetics and pharmacodynamics / Cecile M. Krejsa, Emmanuel Monnet, and Devid Cregut. In vitro and in vivo correlations of pharmacokinetics, pharmacodynamics, and metabolism for hematologic growth factors and cytokines / Graham Molineux In vitro : in vivo correlations of pharmacokinetics, pharmacodynamics, and metabolism for antibody therapeutics / Leslie A. Khawli In vitro : in vivo correlations of pharmacokinetics, pharmacodynamics, and metabolism for extracellular matrix-binding growth factors / Mathew Nugent Metabolic processes at injection sites affecting pharmacokinetics, pharmacodynamics, and metabolism of protein and peptide therapeutics / Randall Mrsny Local tissue responses to polymer implants affecting pharmacokinetics, pharmacodynamics, and metabolism of proteins and peptides / James Anderson Engineering as a means to improve the pharmacokinetics of injected therapeutic proteins / Henry Lowman Ophthalmic delivery of protein and peptide therapeutics : pharmacokinetics, pharmacodynamics, and metabolism considerations / Arto Urtti Pharmacokinetic and pharmacodynamic aspects of intranasal delivery / Rick Costantino Oral delivery of protein and peptide therapeutics : PK/PD considerations / Steven Dinh Drug interaction studies of therapeutic biologics : protein and peptide actions and interactions that alter their pharmacokinetics, pharmacodynamics, and metabolism / Iftekhar Mahmood Intersection of pharmacogenetics with pharmacokinetics and pharmacodynamics / Cecile Krejsa.