Proteinases in inflammation and tumor invasion : Review articles including those from an international conference, Bielefeld, Federal Republic of Germany March 14-16, 1985

In severe inflammatory response, various blood and tissue cells, including polymorphonuclear granulocytes, release lysosomal proteinases, extracellularly and into the circulation. Such enzymes, as well as normally intracellular oxidizing agents produced during phagocytosis, enhance the inflammatory response by degrading connective tissue structures, membrane constituents and soluble proteins by proteolysis or oxidation. We first used polymorphonuclear elastase (E) as a marker of such release reactions. The liberated proteinase competes with susceptible substrates, including Qc^proteinase inhibitor fc^PI) and o^-raacroglobulin, and is eliminated finally as inactive enzyme-inhibitor complexes by the reticuloendothelial system. Using an enzyme-linked immunosorbent assay, we determined the plasma levels of E-fc^PI following major abdominal surgery, multiple trauma and pancreatogenic shock. PREFACE CONTENTS GRANULOCYTE PROTEINASES AS MEDIATORS OF UNSPECIFIC PROTEOLYSIS IN INFLAMMATION: A REVIEW EFFECT OF GRANULOCYTE ELASTASE ON THE METABOLISM OF PROTEOGLYCANS IN INFLAMMATORY JOINT DISEASES PROTEINASE INHIBITOR THERAPY OF SEVERE INFLAMMATION IN PIGS: FIRST RESULTS WITH EGLIN, A POTENT INHIBITOR OF GRANULOCYTE ELASTASE AND CATHEPSIN G MAST CELLS AND MATRIX DEGRADATION IN THE RHEUMATOID JOINT HUMAN CATHEPSIN B, H AND L AND THEIR ENDOGENOUS PROTEIN INHIBITORS : STRUCTURE, FUNCTION AND BIOLOGICAL ROLE CATHEPSIN B: A PROTEINASE LINKED TO METASTASIS? THE COLLAGENS - MOLECULAR AND MACROMOLECULAR STRUCTURES PROTEOLYTIC MODIFICATIONS OF TYPE VI COLLAGEN DEGRADATION OF SPECIFIC COLLAGENS BY MACROPHAGES AND NEUTROPHILS CONNECTIVE TISSUE METALLOPROTEINASES AND MATRIX DEGRADATION TISSUE INHIBITOR OF METALLOPROTEINASES COLLAGEN DEGRADATION IN PERIODONTAL DISEASES INTERSTITIAL COLLAGENASE, GELATINASE AND A SPECIFIC TYPE IV/V (BASEMENT MEMBRANE)COLLAGEN DEGRADING PROTEINASE FROM HUMAN LEUKOCYTES THE ROLE OF CELL MOTILITY IN TUMOR INVASION PERITUMORAL EXTRACELLULAR MATRIX DEGRADATION IN THE LOOSE CONNECTIVE TISSUE OF THE MESENTERY PLASMINOGEN ACTIVATORS AND TUMOR INVASION THE ROLE OF PROTEINASE INHIBITORS IN CELLULAR INVASIVENESS: Purification and characterization of a serine proteinase inhibitor from rat chondrosarcoma CHARACTERIZATION OF A COLLAGENASE INHIBITOR FROM HUMAN AMNIOTIC FLUID WHICH INHIBITS TUMOR CELL INVASION DEVELOPMENT OF A DIRECT MEASUREMENT ASSAY FOR COLLAGENASE AGAINST TYPE I AND TYPE IV COLLAGENS IN TISSUE HOMOGENATE AND ITS APPLICATION IN STOMACH AND LUNG CANCERS METASTATIC ABILITY OF LEWIS LUNG CARCINOMA CELLS AND EXTRACELLULAR PROTEOLYSIS. INTERACTIONS BETWEEN TUMOUR CELLS AND HOST MACROPHAGES IN THE DEGRADATION OF TYPE I AND TYPE IV COLLAGEN A T-LYMPHOMA DERIVED PROTEINASE, SYNERGIZING WITH AN ENDOGLYCOSIDASE IN THE DEGRADATION OF SULPHATED PROTEOGLYCANS IN SUBENDOTHELIAL EXTRACELLULAR MATRIX PROTEOLYTIC ACTIVITY IN CULTURED HUMAN LUNG CANCER CELLS LIST OF AUTHORS SUBJECT INDEX