Protein transfer and organelle biogenesis: edited by Rathindra C. Das, Phillips W. Robbins

Protein Transfer and Organelle Biogenesis is a seven-section volume focusing on the property of proteins to carry signals for secretion, mitochondrial assembly, and lysosomal localizations. It describes how these signals function and determines other factors necessary in building and maintaining the functions of a cell. Organized into seven sections encompassing 19 chapters, the book deals with the general aspects of protein translocation, modification, and sorting. It discusses the transport into the endoplasmic reticulum, the role of carbohydrates in glycoprotein trafficking, and the mechanism of endo- and exocytosis. It further discusses the localization of proteins to the mitochondrion and nucleus and with bacterial protein transport. The final section emphasizes the contribution secretion research that the biotechnology industry has made to the production of proteins. Biologists, cell biologists, researchers, teachers, and students who are interested in the mechanism of protein transfer and organelle biogenesis will find this book invaluable. Content: Front Matter , Page iii Copyright , Page iv Contributors , Pages xi-xii Preface , Page xiii , Rathindra C. Das, Phillips W. Robbins 1 - Transport of Proteins into and across the Endoplasmic Reticulum Membrane , Pages 3-47 , EVE PERARA, VISHWANATH R. LINGAPPA 2 - Role of Carbohydrate in Glycoprotein Traffic and Secretion , Pages 51-108 , JAMES B. PARENT 3 - Membrane Insertion and Transport of Viral Glycoproteins: A Mutational Analysis , Pages 109-158 , ERIC HUNTER 4 - Posttranslational Modification during Protein Secretion , Pages 159-208 , KURT W. RUNGE 5 - Mannosidases in Mammalian Glycoprotein Processing , Pages 209-240 , KELLEY W. MOREMEN, OSCAR TOUSTER 6 - Biosynthesis and Sorting of Proteins of the Endoplasmic Reticulum , Pages 243-288 , MICHAEL GREEN, RICHARD A. MAZZARELLA 7 - Functional Topology of Golgi Membranes , Pages 289-316 , BECCA FLEISCHER 8 - Protein Sorting and Biogenesis of the Lysosome-like Vacuole in Yeast , Pages 317-362 , JOEL H. ROTHMAN, TOM H. STEVENS 9 - Transport and Targeting of Lysosomal Enzymes in Dictyostelium discoideum , Pages 363-399 , JAMES A. CARDELLI, RANDALL L. DIMOND 10 - Organelles of Endocytosis and Exocytosis , Pages 401-461 , JOHN A. HANOVER, ROBERT B. DICKSON 11 - Endocytosis and Compartmentalization of Lysosomal Enzymes in Normal and Mutant Mammalian Cells: Mannose 6-Phosphate-Dependent Pathways , Pages 463-520 , APRIL R. ROBBINS 12 - Biogenesis of Secretory Vesicles , Pages 521-561 , HSIAO-PING HSU MOORE, LELIO ORCI, GEORGE F. OSTER 13 - Expression of Extracellular Matrixlike Glycoproteins by Macrophages and Other Leukocytes , Pages 563-584 , ARTHUR M. MERCURIO 14 - Synthesis and Export of Lipoproteins in Bacteria , Pages 587-606 , MIGUEL REGUE, HENRY C. WU 15 - Protein Secretion across the Outer Membrane of Gram-Negative Bacteria , Pages 607-652 , ANTHONY P. PUGSLEY 16 - Genetic Approaches to the Study of Mitochondrial Protein Import , Pages 655-676 , MARJORIE C. BRANDRISS 17 - Synthesis and Assembly of Mitochondrial Proteins , Pages 677-746 , DONALD W. NICHOLSON, WALTER NEUPERT 18 - Transport of Proteins into the Nucleus , Pages 749-769 , PAMELA A. SILVER, MICHAEL N. HALL 19 - Secretion Research in Industrial Mycology , Pages 773-810 , RAMUNAS BIGELIS, RATHINDRA C. DAS Index , Pages 811-851