Protein-Solvent Interactions

This work covers advances in the interactions of proteins with their solvent environment and provides fundamental physical information useful for the application of proteins in biotechnology and industrial processes. It discusses in detail structure, dynamic and thermodynamic aspects of protein hydration, as well as proteins in aqueous and organic solvents as they relate to protein function, stability and folding. This Practical Resource Covers The Latest Advances In The Interactions Of Proteins With Their Solvent Environment And Provides Fundamental Physical Information Useful For The Application Of Proteins In Biotechnology And Industrial Processes. It Discusses In Detail Structural, Dynamic, And Thermodynamic Aspects Of Protein Hydration As Well As Proteins In Aqueous And Organic Solvents As They Relate To Protein Function, Stability, And Folding. Presenting Integrated Analyses Of The Most Recent Results, Protein-solvent Interactions Examines The Construction Of Proteins And The Protein Devices That Underlie Protein Function And Stability, Furnishing A New Paradigm For Protein Research ... Reviews X-ray Crystallographic Results On The Patterns Of Solvent Structure In And Around Proteins ... Studies Protein Hydration, Glass Transitions, And The Plasticizing Action Of Water, Leading To A Unifying Description Of Protein Dynamics ... Highlights Results From Dielectric Relaxation, Rayleigh Scattering Of Mossbauer Radiation, Positron Annihilation Lifetime Spectroscopy, Hydrogen Isotope Exchange, And Flash Photolysis Techniques ... Outlines Brownian Dynamics, Kramers's Theory, And The Effects Of Solvent Viscosity On Protein Dynamics ... Defines The Thermodynamic Nonideality Of Proteins In Water-cosolvent Mixtures In Terms Of Excluded Volume And Preferential Interactions, Supplying A New Appreciation Of Binding Phenomena ... Offers An Inventory Of Solvent-induced Effects On Protein Stability, Association, And Folding And Shows How To Obtain The Missing Thermodynamic Data ... Introduces A New Approach To Protein Separation Problems ... And Much More. 1. The New Paradigm For Protein Research / Rufus Lumry -- 2. Solvent Interactions With Proteins As Revealed By X-ray Crystallographic Studies / Edward N. Baker -- 3. Protein Hydration And Glass Transition Behavior / Roger B. Gregory -- 4. Dielectric Studies Of Protein Hydration / Ronald Pethig -- 5. Protein Dynamics: Hydration, Temperature, And Solvent Viscosity Effects As Revealed By Rayleigh Scattering Of Mossbauer Radiation / Vitalii I. Goldanskii And Yurii F. Krupyanskii -- 6. Proteins In Essentially Nonaqueous Environments / Darrell L. Williams, Jr., Igor Rapanovich And Alan J. Russell -- 7. Solvent Viscosity Effect On Protein Dynamics: Updating The Concepts / Benjamin Gavish And Saul Yedgar -- 8. Effect Of Solvent On Protein Internal Dynamics: The Kinetics Of Ligand Binding To Myoglobin / Wolfgang Doster, Thomas Kleinert, Frank Post And Marcus Settles -- 9. Solvent Effects On Protein Stability And Protein Association / Arieh Ben-naim. Edited By Roger B. Gregory. Includes Bibliographcial References And Index. Covers advances in the interactions of proteins with their solvent environment. This book provides fundamental physical information useful for the application of proteins in biotechnology and industrial processes. It also discusses in detail structure, dynamic and thermodynamic aspects of protein hydration.