Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies (Enzyme Inhibitors)

Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet been established. This research is starting to shed light on the molecular and biochemical basis of a number of neurodegenerative diseases of dramatic impact. Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies addresses key issues concerning protein misfolding and aggregation in neurodegenerative diseases. Building on recent developments, including the recognition of protein misfolding as both a marker and a causal agent, the text presents the work of those who are actively pursuing more effective treatments, as well as preventative measures, and a possible cure. These include the use of molecular chaperones to control misfolding and novel pharmaceuticals, as well as the potential role of various inhibitors and NSAIDS. A Comprehensive Multifaceted Examination of the Complex Causal Agents Implicated in Protein Misfolding Divided into five sections, this groundbreaking text provides up-to-date accounts for Alzheimer’s, Parkinson’s, Huntington’s, Amyotrophic Lateral Sclerosis and Transmissible Spongiform Encephalitis. It also explores the highly likelihood that multiple factors, including oxidative stress, play a role in these complex diseases. Protein Folding And Misfolding, Relevance To Disease, And Biological Function / Massimo Stefani -- Alzheimer's Disease / Charlotte E. Teunissen And Tischa J.m. Van Der Cammen -- Improving Cholinergic Transmission -- Cholinergic Transmission And Acetylcholine Release Enhancers / Pierre Francotte, Pascal De Tullio, And Bernard Pirotte -- Ache And Its Inhibition / Jure Stojan -- Ache Inhibitors And Their Clinical Assessment / Pierre Francotte, Pascal De Tullio, And Bernard Pirotte -- Reduction In Plaque Formation -- Secretase And App Processing / Christian Czech, Helmut Jacobsen, And Celine Adessi -- Mechanism Of Plaque Formation And A[b] Aggregation Inhibitors / Christian Czech, Helmut Jacobsen, And Celine Adessi -- Nonsteroidal Anti-inflammatory Drugs / Bruno P. Imbimbo And Francesca Speroni -- 3-hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitors / Dario Cattaneo -- A[b] Polymerization Reduction / Harry Levine Iii And Corrine E. Augelli-szafran -- Carbonic Anhydrase Activators As Potential Anti-alzheimer's Disease Agents / Claudiu T. Supuran And Andrea Scozzafava -- Detection And Reduction Of Neurofibrillary Lesions / Jeff Kuret -- Protein Misfolding In Alzheimer Disease : Pathogenic Or Protective? / Rudy J. Castellani ... [et Al.] -- Enhancement Of Brain Retinoic Acid Levels / Ann B. Goodman ... [et Al.] -- Parkinson's Disease : What Is It? What Causes It? And How Can It Be Cured? / Tom Foltynie, Andrew W. Michell, And Roger A. Barker -- Restoring Dopamine Levels / P. Nuno Palma .. [et Al.] -- Huntington's Disease / Claire-anne Gutekunst And Fran Norflus -- Amyotrophic Lateral Sclerosis (motor Neuron Disease) / Teresa Sanelli ... [et Al.] -- Transmissible Spongiform Encephalopathies / Michael D. Geschwind And Giuseppe Legname -- Overview / H. John Smith, Robert D.e. Sewell, And Claire Simons. Edited By H. John Smith, Claire Simons, Robert D.e. Sewell. Includes Bibliographical References And Index. Protein folding and misfolding, relevance to disease and function / Massimi Stefani Alzheimer's disease / Charlotte E. Teunissen and Tischa M. van der Cammen Improving Cholinergic Transmission Cholinergic transmission and acetylcholine release enhancers / Pierre Francotte, Pascal de Tullio and Bernard Pirotte AChE and its inhibition / Jure Stojan AChE inhibitors and their clinical assessment / Pierre Francotte, Pascal de Tullio and Bernard Pirotte Reduction in plaque formation / Christian Czech, Helmut Jacobsen and Celine Adessi Non-steroidal anti-inflammatory drugs (NSAIDs) / Bruno P. Imbimbo and Francesca Speroni 3-hydroxy-3-methyl-glutaryl-coenzyme reductase inhibitors / Dario Cattaneo A' polymerization reduction / Harry LeVine III and Corrine E. Augelli-Szafran Carbonic anhydrase activators as potential anti-Alzheimer's disease agents / Claudiu T. Supuran and Andrea Scozzafava Detection and reduction of neurofibrillary lesions / Jeff Kuret Protein misfolding in Alzheimer disease : pathogenic or protective? / Rudy J. Castellani ... [et al.] Enhancement of brain retinoic acid levels / Ann B. Goodman ... [et al.] Parkinson's disease : what is it? what causes it? and how can it be cured? / Tom Foltynie, Andrew W. Michell and Roger A. Barker Restoring dopamine levels / Nuno Palma .. [et al.] Huntington's disease / Claire-Anne Gutekunst and Fran Norflus Amyotrophic lateral sclerosis (motor neuron disease) / Teresa Sanelli ... [et al.] Transmissible spongiform encephalopathies (TSEs) / Michael D. Geschwind and Giuseppe Legname Overview / H. John Smith, Claire Simons and Robert D.E. Sewell. Current research suggests that neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and Creutzfeldt-Jacob may be linked to disorders in protein shape referred to as protein misfolding. Continued study in this area could lead to promising advances in future treatment of these diseases. This groundbreaking text describes the latest findings regarding protein misfolding in the context of it being a marker, and perhaps a cause, in neurodegenerative diseases. Comprehensive coverage includes the diverse biochemical targets/markers for each disease, the currently limited success of drug therapies, and the cutting-edge research that could lead to more promising treatments.