Protein Misfolding Diseases: Current and Emerging Principles and Therapies (Wiley Series in Protein and Peptide Science)

Le site de l'éditeur indique : "An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease." 9780470572696.pdf PROTEIN MISFOLDING DISEASES 5 CONTENTS 7 CONTRIBUTORS 13 FOREWORD 21 PREFACE 27 ACKNOWLEDGMENTS 29 INTRODUCTION TO THE WILEY SERIES ON PROTEIN AND PEPTIDE SCIENCE 31 PART I PRINCIPLES OF PROTEIN MISFOLDING 33 1 Why Proteins Misfold 35 2 Endoplasmic Reticulum Stress and Oxidative Stress: Mechanisms and Link to Disease 53 3 Role of Molecular Chaperones in Protein Folding 79 4 Kinetic Models for Protein Misfolding and Association 105 5 Toxicity in Amyloid Diseases 125 6 Autophagy: An Alternative Degradation Mechanism for Misfolded Proteins 145 7 Role of Posttranslational Modifications in Amyloid Formation 163 8 Unraveling Molecular Mechanisms and Structures of Self-Perpetuating Prions 177 9 Caenorhabditis elegans as a Model System to Study the Biology of Protein Aggregation and Toxicity 207 10 Using Drosophila to Reveal Insight Into Protein Misfolding Diseases 223 11 Animal Models to Study the Biology of Amyloid-β Protein Misfolding in Alzheimer Disease 245 PART II PROTEIN MISFOLDING DISEASE: GAIN-OF-FUNCTION AND LOSS-OF-FUNCTION DISEASES 263 12 Alzheimer Disease: Protein Misfolding, Model Systems, and Experimental Therapeutics 265 13 Prion Disease Therapy: Trials and Tribulations 291 14 Misfolding and Aggregation in Huntington Disease and Other Expanded Polyglutamine Repeat Diseases 337 15 Systemic Amyloidoses 357 16 Hemodialysis-Related Amyloidosis 379 17 Copper–Zinc Superoxide Dismutase, Its Copper Chaperone, and Familial Amyotrophic Lateral Sclerosis 413 18 Alpha-1-Antitrypsin Deficiency 435 19 Folding Biology of Cystic Fibrosis: A Consortium-Based Approach to Disease 457 20 Thiopurine S-Methyltransferase Pharmacogenomics: Protein Misfolding, Aggregation, and Degradation 485 21 Gaucher Disease 501 22 Cataract as a Protein-Aggregation Disease 519 23 Islet Amyloid Polypeptide 549 PART III ROLE OF ACCESSORY MOLECULES AND RISK FACTORS 575 24 Role of Metals in Alzheimer Disease 577 25 Why Study the Role of Heparan Sulfate in In Vivo Amyloidogenesis? 591 26 Serum Amyloid P Component 603 27 Role of Oxidatively Stressed Lipids in Amyloid Formation and Toxicity 617 28 Role of Oxidative Stress in Protein Misfolding and/or Amyloid Formation 647 29 Aging and Aggregation-Mediated Proteotoxicity 663 PART IV MEDICAL ASPECTS OF DISEASE: DIAGNOSIS AND CURRENT THERAPIES 677 30 Imaging of Misfolded Proteins 679 31 Diagnosis of Systemic Amyloid Diseases 705 32 Identification of Biomarkers for Diagnosis of Amyloid Diseases: Quantitative Free Light-Chain Assays 721 33 Real-Time Observation of Amyloid-β Fibril Growth by Total Internal Reflection Fluorescence Microscopy 731 34 Current and Future Therapies for Alzheimer Disease 743 35 Current Therapies for Light-Chain Amyloidosis 807 36 Familial and Senile Amyloidosis Caused by Transthyretin 827 37 Identifying Targets in α-Synuclein Metabolism to Treat Parkinson Disease and Related Disorders 849 38 Emerging Molecular Targets in the Therapy of Dialysis-Related Amyloidosis 875 39 Familial Amyloidosis Caused by Lysozyme 899 40 Therapeutic Prospects for Polyglutamine Disease 919 PART V APPROACHES FOR NEW AND EMERGING THERAPIES 935 41 Chemistry and Biology of Amyloid Inhibition 937 42 Immunotherapy in Secondary and Light-Chain Amyloidosis 949 43 Anti-Misfolding and Anti-Fibrillization Therapies for Protein Misfolding Disorders 965 44 Therapies Aimed at Controlling Gene Expression, Including Up-Regulating a Chaperone or Down-Regulating an Amyloidogenic Protein 977 45 Understanding and Ameliorating the TTR Amyloidoses 999 INDEX 1037 0471799289,9780471799283,0470572698,9780470572696 Le site de l'éditeur indique : "An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease." An increasingly aging population will add to the number of individuals suffering from amyloid. This book provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease