Protein metabolism : influence of growth hormone, anabolic steroids, and nutrition in health and disease ; an international symposium, Leyden, 25th-29th June, 1962, sponsored by Ciba

The Symposium on "Protein Metabolism: Infiuence of Growth Hormone, Anabolie Steroids, and Nutrition in Health and Disease" is the fourth in the series of International Symposia sponsored by CIBA Limited, Basle. As in the case of the previous conferences, it was planned and organised with the help of experts in the field concerned. Special thanks are due to Prof. A. QuERIDO and Dr. A. A. H. KAssENAAR who, once the idea of the Symposium had been conceived in the course of joint discussions, embarked upon the project with enthusiasm and inspiration, although they must have known full weil what a great deal of time and trouble the organisation of such a meeting would inevitably cost them. For their untiring efforts, for the judicious manner in which they contrived to select precisely those subjects on which interest is chiefiy centred today, and-last but not least-for their success in finding competent specialists to participate in the proceedings, we wish to assure them of our sincere gratitude. To all the members of the Department of Clinical Endocrinology and Diseases of Metabolism, at the University Hospital in Leyden, who helped in preparing the meeting, we would likewise extend a warm vote of thanks. The fact that the present volume, featuring the papers and discussions of the Symposium, has been published only a few months after the event, was made possible thanks to the co­ operative help of all who participated. Front Matter....Pages I-XI Protein metabolism Some problems brought into focus....Pages 1-7 The effect of growth hormone on protein synthesis....Pages 8-25 Regulation of protein synthesis by androgens and estrogens....Pages 26-44 Histological aspects of the action of androgens and oestrogens....Pages 45-77 Introduction to the General Discussion: The importance of experimental conditions for the demonstration of hormone effects in vitro and in vivo ....Pages 78-89 Protein malnutrition and replenishment with protein in man and animals....Pages 90-108 The bearing of the plane of nutrition on growth and endocrine development....Pages 109-120 Metabolic effects of growth hormone in man....Pages 121-136 Nitrogen balance studies: the relation of protein metabolism to excessive shifts of sodium and potassium....Pages 137-149 Studies of protein metabolism in humans with the aid of N 15 -labelled glycine....Pages 150-160 Introduction to the General Discussion: Homoeostasis in protein metabolism....Pages 161-169 Differentiation of action of various anabolic steroids....Pages 170-184 Evaluation of long-acting anabolic steroids....Pages 185-201 The influence of nutrition and nutritional status on the effect of androgens and anabolic agents....Pages 202-221 Effects of anabolic steroids on nucleic acid and protein metabolism....Pages 222-237 Effect of steroids on bone formation....Pages 238-267 Introduction to the General Discussion: Effects of protein deficiency on the endocrine system....Pages 268-274 The effect of injury upon human protein metabolism....Pages 275-299 Human liver cirrhosis secondary to nutritional deficiency....Pages 300-313 I 131 -albumin metabolism in human adults after experimental protein depletion and repletion....Pages 314-325 Muscular protein metabolism in normal and diseased states....Pages 326-351 Introduction to the General Discussion: Some aspects of protein metabolism in surgical trauma and injury....Pages 352-360 The evaluation of growth and maturity in children....Pages 361-382 Use of anabolic agents in disorders of growth....Pages 383-404 Definition, aetiology, and effects of osteopenia....Pages 405-411 Anabolic steroids in the treatment of osteopenia....Pages 412-426 Introduction to the General Discussion: Some endocrine aspects of growth and bone....Pages 427-433 The effects of anabolic steroids on liver function....Pages 434-449 Anabolic steroids in the treatment of renal failure....Pages 450-481 Action of anabolic steroids on red-cell production....Pages 482-493 Concluding Discussion....Pages 494-499 Summing up....Pages 500-505 Back Matter....Pages 506-544 The Symposium on "Protein Metabolism: Infiuence of Growth Hormone, Anabolie Steroids, and Nutrition in Health and Disease" is the fourth in the series of International Symposia sponsored by CIBA Limited, Basle. As in the case of the previous conferences, it was planned and organised with the help of experts in the field concerned. Special thanks are due to Prof. A. QuERIDO and Dr. A.A.H. KAssENAAR who, once the idea of the Symposium had been conceived in the course of joint discussions, embarked upon the project with enthusiasm and inspiration, although they must have known full weil what a great deal of time and trouble the organisation of such a meeting would inevitably cost them. For their untiring efforts, for the judicious manner in which they contrived to select precisely those subjects on which interest is chiefiy centred today, and-last but not least-for their success in finding competent specialists to participate in the proceedings, we wish to assure them of our sincere gratitude. To all the members of the Department of Clinical Endocrinology and Diseases of Metabolism, at the University Hospital in Leyden, who helped in preparing the meeting, we would likewise extend a warm vote of thanks. The fact that the present volume, featuring the papers and discussions of the Symposium, has been published only a few months after the event, was made possible thanks to the coƯ operative help of all who participated