Protein Ligation and Total Synthesis I (Topics in Current Chemistry Book 362)

Each Review Within The Volume Critically Surveys One Aspect Of That Topic And Places It Within The Context Of The Volume As A Whole. The Most Significant Developments Of The Last 5 To 10 Years Are Presented Using Selected Examples To Illustrate The Principles Discussed. The Coverage Is Not Intended To Be An Exhaustive Summary Of The Field Or Include Large Quantities Of Data, But Should Rather Be Conceptual, Concentrating On The Methodological Thinking That Will Allow The Non-specialist Reader To Understand The Information Presented. Contributions Also Offer An Outlook On Potential Future Developments In The Field. From The Contents: Total Synthesis Of Glycosylated Proteins -- Chemical Synthesis Of Cyclic Proteins -- Hydroxylamine Ketoacid Ligation -- Chemical Synthesis Of Ubiquitinated Proteins -- Solid Phase Chemical Synthesis Of Proteins. Lei Liu, Editor ; With Contributions By J. Brailsford [and More]. Includes Index. Front Matter....Pages i-vii Total Synthesis of Glycosylated Proteins....Pages 1-26 Modern Extensions of Native Chemical Ligation for Chemical Protein Synthesis....Pages 27-87 Chemical Methods for Protein Ubiquitination....Pages 89-106 Peptide Thioester Formation via an Intramolecular N to S Acyl Shift for Peptide Ligation....Pages 107-135 Chemical Synthesis and Biological Function of Lipidated Proteins....Pages 137-182 Protein Chemical Synthesis in Drug Discovery....Pages 183-228 Applications of Chemical Ligation in Peptide Synthesis via Acyl Transfer....Pages 229-265 Back Matter....Pages 267-270