Protein-Ligand Interactions : Proceedings of the Symposium held at the University of Konstanz, Germany, September 1974

Die humanistische und frühbarocke Rezeption des Sophokles im deutschen Sprachraum ist weniger erforscht als diejenige anderer antiker Dichter. Die hier angezeigte Monographie erkundet zunächst die Wege der Aneignung und Kanonisierung der griechischen Tragödie durch die frühen Humanisten, die vornehmlich nach chrestomathischen Kriterien erfolgte. Sodann wird die dichtungstheoretische Würdigung des Sophokleischen Werks in der humanistischen Stillehre und Dramentheorie und in den frühbarocken Poetiken der Jesuiten erörtert, die das Schultheater maßgeblich beeinflußten. Der allmähliche Abbau der Sprachbarriere des Griechischen und die Rezeption der Aristotelischen Poetik trugen entscheidend zur produktiven Anverwandlung der Sophokleischen Dramatik bei. Schließlich wird die Umformung der Sophokleischen Gestalten und Texte in mythologischen Handbüchern und Lexika, in Übersetzungen und in Schultheateraufführungen, etwa an den Gymnasien von Altdorf und von Straßburg, exemplarisch dargestellt. Am Vergleich mehrerer Bearbeitungen desselben Stoffes lassen sich divergierende Deutungsmuster einer von verschiedenen intellektuellen Positionen bestimmten Zeit dokumentieren. Als Höhe- und Wendepunkt dieser Entwicklung verweist Opitzens "Verteutschung" auf die stärker als bisher in der Forschung angenommenen humanistischen Wurzeln und Absichten seines Sophokles-Verständnisses, das zugleich das erste Kunstdrama in deutscher Sprache hervorbrachte. Preface Section I. General Letter from J. Wyman to the Members of the Symposium Concerted Changes in an Allosteric Macromolecule Ligand Interactions in Globular Proteins Discussion Ligand Binding to Enzyme Complexes Discussion Properties of Polymeric Proteins Bound to Solid Matrices: Subunit Exchange Chromatography Discussion Contributions of Aromatic Amino Acid Residues to the Optical Activity of Protein-Ligand Complexes Discussion Section II. Enzymes The Architecture of the Coenzyme Binding Domain in Dehydrogenases as Revealed by X-Ray Structure Analysis Discussion The Interaction of Glutamate Dehydrogenase with a Coenzyme Analog Discussion The Interaction of Adenosine Triphosphate and its Analogs with Myosin and the Modification by Actin Discussion Isolation of a Guanylnucleotide Binding Protein from Pigeon Erythrocyte Membranes Discussion On the Binding of Isoleucine and Related Amino Acids to Isoleucyl-tRNA Synthetase from Escherichia Coli MRE 600 Discussion The Effect of Small Molecules on the Affinity of Individual Chains in Hemoglobin and on its Cooperativity Discussion Cooperative Interactions without Symmetry or Subunits Discussion A Nuclear Magnetic Resonance Study of Activator Binding by Carboxypeptidase A Discussion Section III. Repressors Lactose Operator Sequences and the Action of Lac Repressor Discussion The Active Sites of Lac Repressor Discussion Lac Repressor Discussion The Use of Suppressed Nonsense Mutations to Generate Altered Lac Repressor Molecules Discussion Effect of Alterations in Lac Operator DNA on Repressor Binding Discussion Interaction of Lac Repressor with Non-Specific DNA Binding Sites Discussion Section IV. Receptors Binding and Functional States of the Cholinergic Receptor Protein from Torpedo Marmorata Discussion Subunit Structure and Binding Sites of the Acetylcholine Receptor Discussion Further Characterization of Purified Acetylcholine Receptor and its Incorporation into Phospholipid Vesicles Discussion Structural and Functional Studies of an Acetylcholine Receptor Discussion Section V. Antibodies, Drugs and Metabolites Antibody Combining Sites as a Model for Molecular Recognition Discussion Antibiotic Action on Enzymes Involved in Peptidoglycan Synthesis Discussion Problems in Studying Protein Binding with Regard to the Interaction of Steroids with a Specific Binding Globulin Discussion The Interaction of Low-Molecular Compounds with Serum Albumin as Measured by Optical Methods. Circular Dichroism of Bilirubin-Human Serum Albumin Complexes in the Presence of Alcohols in Aqueous Solution Discussion Section VI. Detergents and Electrolytes The Nature of Specific and Non-Specific Interactions of Detergents with Proteins: Complexing and Unfolding Discussion Interaction of Detergents with Proteins: Effect of Counter Ions on the System Ferrimyoglobin- Laurylpyridinium Halides in Aqueous Medium Discussion Influence of Ions on the Kinetics of Cooperative Conformational Changes in Globular Proteins Discussion Neutral Salt Effects on the Conformational Stability of Biological Macromolecules Discussion Concluding Remarks Index of Contributors Subject Index