Protein Degradation: Ubiquitin and the Chemistry of Life, Volume 1

The first volume in a new series dedicated to protein degradation, this book lays the foundations of targeted protein breakdown via the ubiquitin pathway. The outstanding importance of the ubiquitin pathway has been recognized with the 2004 Nobel Prize in Chemistry for Aaaron Chiechanover, Avram Hershko, and Irwin Rose. Aaron Ciechanover is one of the editors of this series, and Avram Hershko has contributed to the opening chapter of the present volume. Drawing on the the expertise of two Nobel prize winners, this handy reference compiles information on the initial steps of the ubiquitin pathway. Starting out with a broad view of protein degradation and its functions in cellular regulation, it then goes on to examine the molecular mechanisms of ubiquitin conjugation and recycling in detail. All currently known classes of ubiquitin protein ligases are treated here, including latest structural data on these enzymes. Further volumes in the series cover the function of the proteasome, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.Content: Chapter 1 Brief History of Protein Degradation and the Ubiquitin System (pages 1–9): Avram Hershko Chapter 2 N?terminal Ubiquitination: No Longer Such a Rare Modification (pages 10–20): Prof. Dr. Aaron Ciechanover Chapter 3 Evolutionary Origin of the Activation Step During Ubiquitin?dependent Protein Degradation (pages 21–43): Hermann Schindelin Chapter 4 RING Fingers and Relatives: Determinators of Protein Fate (pages 44–101): Kevin L. Lorick, Yien?Che Tsai, Yili Yang and Allan M. Weissman Chapter 5 Ubiquitin?conjugating Enzymes (pages 102–134): Michael J. Eddins and Cecile M. Pickart Chapter 6 The SCF Ubiquitin E3 Ligase (pages 135–155): Leigh Ann Higa and Hui Zhang Chapter 7 The Structural Biology of Ubiquitin–Protein Ligases (pages 156–189): Ning Zheng and Nikola P. Pavletich Chapter 8 The Deubiquitinating Enzymes (pages 190–219): Nathaniel S. Russell and Keith D. Wilkinson Chapter 9 The 26S Proteasome (pages 220–247): Prof. Dr. Martin Rechsteiner Chapter 10 Molecular Machines for Protein Degradation (pages 248–287): Matthias Bochtler, Michael Groll, Hans Brandstetter, Tim Clausen and Robert Huber Chapter 11 Proteasome Regulator, PA700 (19S Regulatory Particle) (pages 288–316): George N. DeMartino and Cezary Wojcik Chapter 12 Bioinformatics of Ubiquitin Domains and Their Binding Partners (pages 318–347): Kay Hofmann Chapter 13 The COP9 Signalosome: Its Possible Role in the Ubiquitin System (pages 348–369): Dawadschargal Bech?Otschir, Barbara Kapelari and Wolfgang Dubiel v. 1. Ubiquitin and the chemistry of life. 1. Brief history of protein degradation and the ubiquitin system / Avram Hershko 2. N-terminal ubiquitination: no longer such a rare modification / Aaron Ciechanover 3. Evolutionary origin of the activation step during ubiquitin-dependent protein degradation / Hermann Schindelin 4. RING fingers and relatives: determinators of protein fate / Kevin L. Lorick ... [et al.] 5. Ubiquitin-conjugating enzymes / Michael J. Eddins and Cecile M. Pickart 6. The SCF ubiquitin E3 ligase / Leigh Ann Higa and Hui Zhang 7. The structural biology of ubiquitin-protein ligases / Ning Zheng and Nikola P. Pavletich 8. The deubiquitinating enzymes / Nathaniel S. Russell and Keith D. Wilkinson 9. The 26S proteasome / Martin Rechsteiner 10. Molecular machines for protein degradation / Matthias Bochtler ... [et al.] 11. Proteasome regulator, PA700 (19S regulatory particle) / George N. DeMartino and Cezary Wojcik 12. Bioinformatics of ubiquitin domains and their binding partners / Kay Hofmann 13. The COP9 signalosome: its possible role in the ubiquitin system v. 2. The ubiquitin-proteasome system. 1. Molecular chaperones and the ubiquitin-proteasome system / Cam Patterson and Jörg Höhfeld 2. Molecular dissection of autophagy in the yeast Saccharomyces cerevisiae / Yoshinori Ohsumi 3. Dissecting intracellular proteolysis using small molecule inhibitors and molecular probes / Huib Ovaa ... [et al.] 4. MEKK1: dual function as a protein kinase and a ubiquitin protein ligase / Zhimin Lu and Tony Hunter 5. Proteasome activators / Andreas Förster and Christopher P. Hill 6. The proteasome portal and regulation of proteolysis / Monika Bajorek and Michael H. Glickman 7. Ubiquity and diversity of the proteosome system / Keiji Tanaka, Hideki Yashiroda, and Shigeo Murata 8. Proteasome-interacting proteins / Jean E. O'Donoghue and Colin Gordon 9. Structural studies of large, self-compartmentalizing proteases / Beate Rockel, Jürgen Bosch, and Wolfgang Baumeister 10. What the archaeal PAN - proteasome complex and bacterial ATP-dependent proteases can teach us about the 26S proteasome / Nadia Benaroudj, David Smith, and Alfred L. Goldberg 11. Biochemical functions of ubiquitin and ubiquitin-like protein conjugation / Mark Hochstrasser v. 3. Cell biology of the ubiquitin-proteasome system. 1. Ubiquitin: a new player in the peroxisome field / Astrid Kragt, Rob Benne, Ben Distel 2. Ubiquitin proteasome system and muscle development / Johnny Kim, Thorsten Hoppe 3. COP9 signalosome: structural and biochemical conservation and its roles in the regulation of plant development / Vicente Rubio and Xing Wang Deng 4. Ubiquitin and protein sorting to the lysosome / John McCullough, Michael J. Clague, Sylvie Urbé 5. ISG15-dependent regulation / Arthur L. Haas 6. Role of the ubiquitin-proteasome pathway in the regulation of the cellular hypoxia response / Koh Nakayama and Ze'ev Ronai 7. p97 and ubiquitin: a complex story / Louise C. Briggs ... [et al.] 8. Cdc48 (p97) and its cofactors / Alexander Buchberger 9. Deubiquitinating enzymes, cell proliferation, and cancer / Rohan T. Baker Biochemists and related specialists from around the world explore the ubiquitin system, now known to be involved in basic biological processes such as the control of cell division, signal transduction, the regulation of transcription, DNA repair, quality control in the endoplasmic reticulum, apoptosis, embryonic development, circadian clocks, and who knows what else at night and on weekends when the scientists are at home. The topics include the evolutionary origin of the activation step during ubiquitin-dependent protein degradation, RING fingers and relatives as determiners of protein fate, ubiquitin- conjugating enzymes, the structural biology of ubiquitin-protein ligases, and the crucial 26S proteasome. Annotation : 2004 Book News, Inc., Portland, OR (booknews.com)