Proteases in Tissue Remodelling of Lung and Heart (Proteases in Biology and Disease (1))

Proteases in Tissue Remodelling of Lung and Heart is unique for its comprehensive presentation of protease function in lung and heart under both physiological conditions and major diseases manifesting in these two organs. The individual chapters have been written by leaders in the field who paid much attention to outline in great detail the role of proteases in the pathogenesis, diagnosis and treatment of disease. Available animal models (of disease, transgenic, or knock-out) are extensively referred to and experimental data obtained thereby are discussed in the context of patient-derived data. Newcomers to the field and interested non-specialists will take advantage of the extensive introduction to individual proteases, protease families and the diseases. Understanding is greatly facilitated by the clear and condensed presentation of summarised data in tables and graphs. Thus, the book should be a valuable source for both clinicians and researchers interested in protease function and/or diseases of lung and heart. Proteases in Tissue Remodelling of Lung and Heart: *is devoted to proteases in lung and heart specifically and extensively, *covers major diseases of the lung and heart, *extensively introduces individual proteases (or families thereof), *presents up-to-date patient-derived and experimental data, *covers most aspects of protease function in disease. Proteases in Tissue Remodelling of Lung and Heart is unique for its comprehensive presentation of protease function in lung and heart under both physiological conditions and major diseases manifesting in these two organs. The individual chapters have been written by leaders in the field who paid much attention to cover in great detail the role of proteases in the pathogenesis, diagnosis, and treatment of disease. Available animal models (of disease, transgenic, or knock-out) are extensively referred to and experimental data obtained thereby are discussed in the context of patient-derived data. Newcomers to the field and interested non-specialists will take advantage of the extensive introduction to individual proteases, protease families, and the diseases. Understanding is greatly facilitated by the clear and condensed presentation of summarised data in tables and graphs. Thus, the book should be a valuable source for both clinicians and researchers interested in protease function and/or diseases of lung and heart Front Matter....Pages i-xvi Human leukocyte elastase and cystic fibrosis....Pages 1-33 Matrix Metalloproteinases in inflammation of the lung....Pages 35-56 Proteases in interstitial lung diseases....Pages 57-73 Matrix Metalloproteinase Inhibitors in Cancer Therapy....Pages 75-118 The Role of Proteases in the Pathogenesis of Lung Emphysema....Pages 119-126 Cardiac Remodelling in Pressure Overload Hypertrophy....Pages 127-137 Ischemia / Myocardial Infarction....Pages 139-155 Matrix Metalloproteinases and Myocardial Remodeling in Heart Failure....Pages 157-189 Proteases and Arrhythmias....Pages 191-218 Impact of Proteases in Tissue Engineering and Regeneration....Pages 219-228 Back Matter....Pages 229-237 A comprehensive presentation of protease function in lung and heart under both physiological conditions and major diseases manifesting in these two organs. This work refers to available animal models and experimental data obtained thereby are discussed in the context of patient-derived data. Cystic fibrosis (CF) is the most common fatal disease caused by a single gene defect in Europe and North America (Davis et al 1996; Rosenstein and Cutting, 1998).