Proteases and Their Inhibitors in Cancer Metastasis (Cancer Metastasis - Biology and Treatment (4))

In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action of proteases and their inhibitors in tumor biology. The first part provides the reader with a selective overview of the molecular biology of serine proteases, MMPs and their physiological inhibitors. The most important proteases and their physiological as well as synthetic inhibitors are evaluated in the most relevant models of experimental and human cancer. The clinical aspects are also taken into account. This volume offers an update on this challenging aspect of cancer treatment, its interest bias, and possible clinical implication. Molecular Biology of the Plasminogen System: The Delicate Balance between Tissue Healing and Tissue Destruction....Pages 1-22 Role of Serine Proteases and their Inhibitors in Tumor Growth and Angiogenesis....Pages 23-38 The Gelatinases, MMP-2 and MMP-9-Implications for Invasion and Metastasis....Pages 39-52 The Collagenases: Novel Roles for Matrix Metalloproteinases (MMPS) in Invasion and Metastasis....Pages 53-79 Stromelysin-3, a Particular Member of the Matrix Metalloproteinase Family....Pages 81-107 Membrane-Type Matrix Metalloproteinases....Pages 109-125 3D Structure and Drug Design....Pages 127-150 Transcriptional Control of Proteases....Pages 151-168 Tissue Inhibitors of Metalloproteinases in Cancer....Pages 169-194 Clinical Aspects of Matrix Metalloproteinases....Pages 195-204 Tissue Models to Study Tumor-Stroma Interactions....Pages 205-223 Mammalian Heparanase: Molecular Properties, Inhibition and Involvement in Tumor Metastasis and Angiogenesis....Pages 225-252

these Twelve Papers Evaluate The Mechanisms Of Action Of Proteases And Their Inhibitors In Tumor Biology. Beginning With A Selective Overview Of The Relevant Molecular Biology, The Book Evaluates The Physiological And Synthetic Inhibitors In The Various Models Of Experimental And Human Cancer. Specific Chapters Discuss Serine Proteases, Gelatinases, Membrane-type Matrix Metalloproteinases, Drug Design, Clinical Aspects, Tumor-stroma Interactions, And Mammalian Heparanase. Annotation ©2003 Book News, Inc., Portland, Or

This volume offers an update on this aspect of cancer treatment, its interest bias and possible clinical implications, providing an evaluation of the mechanisms of action of proteases and their inhibitors in tumour biology Genetic studies have provided important insights in proteinase biology.