Prostate Cancer: Biochemistry, Molecular Biology and Genetics (Protein Reviews Book 16)

__Prostate Cancer__ provides an up-to-date review of the biochemistry, molecular biology, and genetic changes in prostate cells that are the driving forces in the initiation and progression of cancer. It includes an overview by experts in the field of cell-cell interactions, including stem cells, reactive Stromal cells and membrane lipid rafts that are instrumental in the initiation and progression of prostate cancer. Prostate Cancer Is The Most Frequently Diagnosed Non-cutaneous Malignancy In Men, And The Second Leading Cause Of Male Cancer-related Mortality In The United States. The Last Decade Has Seen Unprecedented Progress In The Detection, Prognosis, Treatment And Prevention Of Prostate Cancer. These Advances Have Been Driven Largely By An Increased Understanding Of The Underlying Biochemistry, Molecular Biology And Genetics Of The Disease. New Cell And Animal Models Have Been Developed That Recapitulate The Natural Progression Of Prostate Cancer. New Technologies Have Allowed Scientists To View In Detail The Genomic, Proteomic, Metabolomics And Other –omic Universe Of Cancer Cells And Tissues. This Has Resulted In A Greater Understanding Of The Pathophysiology Of The Disease. Preface -- Section 1: Cell Biology -- Stem Cells In The Normal And Malignant Prostate -- Role Of Reactive Stroma In Prostate Cancer -- The Role Of Cholesterol In Prostate Cancer -- Section 2: Genetics: Pten In Prostate Cancer -- Ets Fusion Genes In Prostate Cancer -- Section 3: Cell Signaling -- Signaling Mechanisms Of Vav3, A Guanine Nucleotide Exchange Factor And Androgen Receptor Coactivator, In Physiology And Prostate Cancer Progression -- Transforming Growth Factor-beta (tgf-b) In Prostate Cancer -- The P38 Mapk Pathway In Prostate Cancer -- Nf-kappab2/p52 In Prostate Cancer -- The Functional Role Of Dab2ip, A Homeostatic Factor, In Prostate Cancer -- Tyrosine Kinases In Prostate Cancer -- Human Prostatic Acid Phosphatase In Prostate Carcinogenesis -- Section 4: Hormonal -- Truncated Androgen Receptor Splice Variants In Prostate Cancer -- Biology And Clinical Relevance Of Estrogen Receptors In Prostate Cancer -- Vitamin D And Prostate Cancer -- Hdac6 Regulation Of Androgen Signaling In Prostate Cancer -- Beyond The Cell Cycle: Implications Of D-type Cyclin Deregulation In Pca -- Section 5: Cell Death -- Role Of Par- In Prostate Cancer -- Autophagy And Prostate Cancer Therapeutics -- Index. Edited By Donald J. Tindall. Cell biology. Stem cells in the normal and malignant prostate / Norman J. Maitland Role of reactive stroma in prostate cancer / Rebeca San Martin, David R. Rowley The role of cholesterol in prostate cancer / Keith R. Solomon, Kristine Pelton, Michael R. Freeman Genetics. PTEN in prostate cancer / Marcus A. Ruscetti, Hong Wu ETS fusion genes in prostate cancer / J. Chad Brenner, Arul M. Chinnaiyan, Scott A. Tomlins Cell signaling. Signaling mechanisms of Vav3, a guanine nucleotide exchange factor and androgen receptor coactivator, in physiology and prostate cancer progression / Leah S. Lyons, Kerry L. Burnstein Transforming growth factor-beta in prostate cancer / David Danielpour The p38 MAPK pathway in prostate cancer / Daniel Djakiew NF-kappaB2/p52 in prostate cancer / Nagalakshmi Nadiminty, Ramakumar Tummala, Yezi Zhu The functional role of DAB2IP, a homeostatic factor, in prostate cancer / Eun-Jin Yun, Kaijie Wu, Yuh-Shyan Tsai Tyrosine kinases in prostate cancer / Yun Qiu, Dhanraj Deshmukh Human prostatic acid phosphatase in prostate carcinogenesis / Sakthivel Muniyan, Yu-Wei Chou, Shou-Qiang Ou-Yang Hormonal. Truncated androgen receptor splice variants in prostate cancer / Peter E. Lonergan, Donald J. Tindall Biology and clinical relevance of estrogen receptors in prostate cancer / Shuk-Mei Ho, Pheruza Tarapore, Ming-Tsung Lee, and Yuet-Kin Leung Vitamin D and prostate cancer / Jung-Sun Kim, Justin M. Roberts, Nancy L. Weigel HDAC6 regulation of androgen signaling in prostate cancer / Junkui Ai, Zhou Wang Beyond the cell cycle : implications of D-type cyclin deregulation in prostate cancer / Michael A. Augello, William F. Ostrander Jr., Karen E. Knudsen Cell death. Role of par-4 in prostate cancer / Nidhi Shukla, Nikhil K. Hebbar, Vivek M. Rangnekar Autophagy and prostate cancer therapeutics / Hsing-Jien Kung, Chun Changou, Hao G. Nguyen, Joy C. Yang, Christopher P. Evans, Richard J. Bold, and Frank Chuang. Front Matter....Pages i-xii Front Matter....Pages 1-1 Stem Cells in the Normal and Malignant Prostate....Pages 3-41 Role of Reactive Stroma in Prostate Cancer....Pages 43-63 The Role of Cholesterol in Prostate Cancer....Pages 65-83 Front Matter....Pages 85-85 PTEN in Prostate Cancer....Pages 87-137 ETS Fusion Genes in Prostate Cancer....Pages 139-183 Front Matter....Pages 185-185 Signaling Mechanisms of Vav3, a Guanine Nucleotide Exchange Factor and Androgen Receptor Coactivator, in Physiology and Prostate Cancer Progression....Pages 187-205 Transforming Growth Factor-Beta in Prostate Cancer....Pages 207-242 The p38 MAPK Pathway in Prostate Cancer....Pages 243-255 NF-kappaB2/p52 in Prostate Cancer....Pages 257-273 The Functional Role of DAB2IP, a Homeostatic Factor, in Prostate Cancer....Pages 275-293 Tyrosine Kinases in Prostate Cancer....Pages 295-322 Human Prostatic Acid Phosphatase in Prostate Carcinogenesis....Pages 323-348 Front Matter....Pages 349-349 Truncated Androgen Receptor Splice Variants in Prostate Cancer....Pages 351-382 Biology and Clinical Relevance of Estrogen Receptors in Prostate Cancer....Pages 383-419 Vitamin D and Prostate Cancer....Pages 421-442 HDAC6 Regulation of Androgen Signaling in Prostate Cancer....Pages 443-459 Beyond the Cell Cycle: Implications of D-type Cyclin Deregulation in Prostate Cancer....Pages 461-477 Front Matter....Pages 479-479 Role of Par-4 in Prostate Cancer....Pages 481-495 Autophagy and Prostate Cancer Therapeutics....Pages 497-518 Back Matter....Pages 519-522 This text reviews biochemistry, molecular biology and genetic changes in prostate cells that are the driving forces in the initiation and progression of cancer. It surveys cell interactions, including stem cells, reactive Stromal cells and membrane lipid rafts