Prostaglandins in Cellular Biology : Proceedings of the ALZA Conference on Prostaglandins in Cellular Biology and the Inflammatory Process Held in Carmel, California, October 24–26, 1971

This book represents the first of the ALZA CONFERENCE SERIES which will deal with a wide variety of topics of biomedical interest. These Conferences are planned to cover a range of subjects from the molecular level, such as drug receptor and drug membrane interactions, to the organ and organismal levels and the dynamics of drug therapy. This year's topic is "PROSTAGLANDINS." It is rapidly becoming clear that prosta­ glandins are of great interest and potential utility in therapeutics. An understanding of the role of prostaglandins in the regulation of cell processes should provide insight into the understanding of a variety of difficult and intransigent fields such as cancer, allergy, and transplant rejection. We hope that this Conference may focus attention on novel approaches to these areas. We wish to thank our distinguished Chairmen and guests for their attendance. The papers and dis­ cussions were prepared by Yvonne Hendrickson, using an ATS/360 Text-Editing System; we acknowledge with gratitude her skill, patience, and hard work. P.W.R. B.B.P. Front Matter....Pages i-xi Introductory Remarks to the First Session....Pages 1-4 Use of Prostaglandins in the Preparation of Blood Components....Pages 5-25 Some Effects of Vasoactive Hormones on the Mammalian Red Blood Cell....Pages 27-60 Use of PGE(1) in Preparation and Storage of Platelet Concentrates....Pages 61-76 Prostaglandin E(1) and E(2): Qualitative Difference in Platelet Aggregation....Pages 77-92 The Effect of Prostaglandins, Epinephrine and Aspirin on Cyclic AMP Phospho Diesterase Activity of Human Blood Platelets and Their Aggregation....Pages 93-110 Leukocyte Cyclic AMP: Pharmacological Regulation and Possible Physiological Implications....Pages 111-149 Effect of Prostaglandins upon Enzyme Release from Lysosomes and Experimental Arthritis....Pages 151-172 The Role of Prostaglandins in the Immune Response....Pages 173-194 The Role of Prostaglandins in the Regulation of Growth and Morphology of Transformed Fibroblasts....Pages 195-205 Prostaglandin Release by Human Cells In Vitro ....Pages 207-226 Release and Actions of Prostaglandins in Inflammation and Fever: Inhibition by Anti-Inflammatory and Antipyretic Drugs....Pages 227-268 Formation of Prostaglandins in the Skin Following a Burn Injury....Pages 269-291 Prostaglandin Inhibition of Immediate and Delayed Hypersensitivity in Vitro ....Pages 293-308 The Role of Prostaglandins in Microcirculatory Regulation and Inflammation....Pages 309-327 Pro-Inflammatory Effects of Certain Prostaglandins....Pages 329-343 Studies on the Mode of Action of Non-Steroidal Anti-Inflammatory Agents....Pages 345-352 Contraction of Isolated Cutaneous Vascular Smooth Muscle and its Response to Prostaglandins....Pages 353-368 Interactions of Prostaglandin E(1) and Catecholamines in Isolated Vascular Smooth Muscle....Pages 369-383 Cellular Aspects of Prostaglandin Synthesis and Testicular Function....Pages 385-398 The Antihypertensive and Natriuretic Endocrine Function of the Kidney: Vascular and Metabolic Mechanisms of the Renal Prostaglandins....Pages 399-449 Prostaglandins and the Microvascular System: Physiological and Histochemical Correlations....Pages 451-478 Effect of Prostaglandins on Adrenergic Neurotransmission to Vascular Smooth Muscle....Pages 479-511 Back Matter....Pages 513-526