Prostaglandins-immunopharmacology: Proceedings of the 7th International Congress of Pharmacology, Paris, 1978 (Advances in pharmacology and therapeutics)

Advances in Pharmacology and Therapeutics, Volume 4: Prostaglandins-Immunopharmacology contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of prostaglandins, their immunopharmacology, and their therapeutic applications. Topics covered range from the biochemistry of prostaglandins, thromboxanes, and prostacyclin to the pharmacology of blood platelets and pharmacological approaches to enhancement of immunity. This volume is comprised of 23 chapters and opens with a discussion on the discovery of prostaglandins and their possible biological functions, including platelet aggregation and adrenergic neurotransmission. The reader is then introduced to unstable metabolites of arachidonic acid in relation to thrombosis; pharmacological interference in biotransformation of arachidonic acid; participation of prostaglandins in inflammatory pain; and factors affecting the formation and actions of cyclic AMP in blood platelets. The following chapters explore the role of thymosin and the endocrine thymus in the maintenance of immune balance; effects of thymosin fraction 5 in cancer patients; and the immunoregulatory activities of non-toxic synthetic polyribonucleotides. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine. Content: ADVANCES IN PHARMACOLOGY AND THERAPEUTICS , Page ii Front Matter , Page iii Copyright , Page iv Introduction , Pages vii-viii , Jacques R BOISSIER Prostaglandins , Pages 3-8 , Ulf S. von Euler Prostaglandin Endoperoxides and Thromboxanes: Biochemistry and Biological Role , Pages 9-12 , Bengt Samuelsson Unstable Metabolites of Arachidonic Acid in Relation to Thrombosis , Pages 13-25 , S. Moncada, J.R. Vane The Role of Biologically Active Lipids in Platelet Aggregation , Pages 27-37 , B.B. Vargaftig, M. Chignard, J. Lefort Synthesis of Prostaglandins by Vascular and Nonvascular Renal Tissues and the Presence of an Endogenous Prostaglandin Synthesis Inhibitor in the Cortex , Pages 39-46 , N.A. Terragno, J.C. McGiff, D.A. Terragno Endogenous and Exogenous Metabolites of Arachidonic Acids and Cyclic Nucleotides in the Central Nervous System , Pages 47-52 , Rodolfo Paoletti Pharmacological Interference in Biotransformation of Arachidonic Acid , Pages 53-62 , R.J. Gryglewski Participation of Prostaglandins in Inflammatory Pain , Pages 63-69 , S.H. Ferreira Introductory Remarks , Pages 73-74 , Fritz Markwardt Factors Affecting the Formation and Actions of Cyclic AMP in Blood Platelets , Pages 75-85 , R.J. Haslam, M.M.L. Davidson, J.V. Desjardins, J.E.B. Fox, J.A. Lynham The Role of Calcium Ions in the Regulation of Platelet Function and Their Pharmacological Control , Pages 87-95 , E.F. Lüscher, P. Massini, R. Käser-Glanzmann Platelet Secretion (Release Reaction)-Mechanism and Pharmacology , Pages 97-109 , Holm Holmsen Prostaglandin Endoperoxides and Thromboxanes: Role in Platelets , Pages 111-115 , Bengt Samuelsson Influence of Antiadrenergic Drugs on Platelet Function , Pages 117-124 , Erika Glusa, Fritz Markwardt Abnormal Platelets as Models for Understanding the Mechanisms of Platelet Function , Pages 125-134 , J.P. Caen, A.T. Nurden, G. Tobelem, F. Rendu, S. Levy-Toledano Mediators of Cellular Immunity , Pages 137-144 , E. Tzehoval, S. Segal, Y. Stabinsky, M. Fridkin, Z. Spirer, M. Feldman A New Approach to Immunostimulation: Thymic Factors , Pages 145-148 , Jean-François Bach Pharmacological Enhancement of Immunity: Role of Thymosin and the Endocrine Thymus in the Maintenance of Immune Balance , Pages 149-157 , T.L.K. Low, S-K. Hu, A.L. Goldstein Effects of Thymosin Fraction 5 in Cancer Patients: In Vitro Studies and Correlations with Clinical Course in Patients Receiving Thymosin , Pages 159-166 , Paul B. Chretien, Stephen D. Lipson, Robert Makuch, Daniel E. Kenady, Jack J. Snyder, Martin H. Cohen Studies of Levamisole in Experimental Tumor Systems , Pages 167-176 , Willem K. Amery, Michael A. Chirigos Studies on the Immunoregulatory Activities of Non-Toxic Synthetic Polyribonucleotides , Pages 177-185 , Arthur G. Johnson, Howard M. Lederman Immunopharmacological Activities of Muramyl Dipeptide, A Synthetic Mycobacterial Analog , Pages 187-196 , L. Chedid Immune Receptors and Cell Differentiation , Pages 199-221 , Norbert Hilschmann, Heinz Ulrich Barnikol, Shitsu Barnikol-Watanabe, Hartmut Kratzin Index , Pages 223-226 Inside Back Cover , Page ibc1 v. 1. Receptors v. 2. Neurotransmitters v. 3. Ions, cyclic nucleotides, cholinergy v. 4. Prostaglandins, immunopharmacology v. 5. Neuropsychopharmacology v. 6. Clinical pharmacology v. 7. Biochemical-clinical pharmacology v. 8. Drug-action modifications, comparative pharmacology v. 9. Toxicology v. 10. Chemotherapy.