Prostaglandins and Thromboxanes : Butterworths Monographs in Chemistry

Prostaglandins and Thromboxanes explores the two members of the prostanoid class of fatty acid. This book attempts to thoroughly discuss the topic after collecting enough information through research in physical and biological sciences. As the title suggests, the book revolves around prostaglandins and thromboxanes. The book's first chapter contains a discussion on the subject's history, stating the year of discovery and crediting the scientist who coined the names. The chapter ends talking about the possible uses of prostaglandins and thromboxanes in the clinic. The chapters that follow discuss the two lipids'basic and advanced synthesis, pharmacology, biosynthesis, biological activity, chemical interconversions, and metabolism, along with its subtopics. The book will serve as an excellent reference for undergraduate and graduate students in the related field. Content: Butterworths Monographs in Chemistry , Page ii Front Matter , Page iii Copyright , Page iv Preface , Page v , Roger F. Newton, Stanley M. Roberts Contributors , Page vii CHAPTER 1 - History, nomenclature and potential uses of prostaglandins and thromboxanes in the clinic , Pages 1-7 , Roger F. Newton, Stanley M. Roberts CHAPTER 2 - Biosynthesis and metabolism of prostaglandins and thromboxanes , Pages 8-18 , Keith H. Gibson CHAPTER 3 - Pharmacology of natural prostaglandins and analogues , Pages 19-36 , Ian Kennedy CHAPTER 4 - Synthesis of prostaglandins from polycyclic molecules , Pages 37-61 , Roger F. Newton, Stanley M. Roberts CHAPTER 5 - Synthesis of prostaglandins involving conjugate addition to cyclopentenones , Pages 62-83 , Feodor Scheinmann CHAPTER 6 - Chemical interconversions of prostaglandins: synthesis of prostaglandins G 2 , H 2 , and I 2 , Pages 84-89 , Roger F. Newton, Stanley M. Roberts CHAPTER 7 - Synthesis of thromboxanes , Pages 90-94 , Richard J.K. Taylor CHAPTER 8 - Synthesis and biological activity of prostaglandin analogues bearing modified side chains , Pages 95-106 , Eric W. Collington CHAPTER 9 - Synthesis and biological activity of prostaglandin analogues with modified ring systems , Pages 107-131 , Roger P. Dickinson CHAPTER 10 - Synthesis and biological activity of thromboxane A 2 (TXA 2 ) analogues , Pages 132-136 , Richard J.K. Taylor Index , Pages 137-143