Progress in molecular biology and translational science. Volume one hundred and thirty two Trafficking of GPCRs

G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell surface receptors that regulate a variety of cell functions. Over the past few decades great progress has been made in defining the roles of intracellular trafficking in controlling the functionality of the receptors as well as in the development of various human diseases. This volume of __Progress in Molecular Biology and Translational Science__ reviews the recent understanding of GPCR trafficking regulators and molecular mechanisms. * Written by future leaders in the pain field * Covers a wide range of targets * Contains provocative ideas about GPCR trafficking Front Cover; Trafficking of GPCRs; Copyright; Contents; Contributors; Preface; Chapter 1: Arrestins: Critical Players in Trafficking of Many GPCRs*; 1. Arrestins and GPCR Trafficking; 2. Non-visual Arrestins Mediate GPCR Internalization via Coated Pits; 3. Visual Arrestins and Trafficking Proteins; 4. Ubiquitination and Deubiquitination in GPCR Cycling and Signaling; 5. Faster Cycling Prevents Receptor Downregulation; 6. Arrestins in Receptor Recycling and Vesicle Trafficking: Questions Without Answers; 7. Conclusions and Future Directions; References