Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques

In the first years of the existence of this series of monographs, during the so-called "Golden Age" of drug research, the majority of the pa­ pers published were mainly concerned with the traditional domains of drug research, namely chemistry, pharmacology, toxicology and pre­ clinical investigations. The series' aim was to give coverage to impor­ tant areas of research, to introduce new active substances with thera­ peutic potential and to call attention to unsolved problems. This objective has not changed. The table of contents of the present volume makes evident, however, that the search for new medicines has become increasingly complex, and additional, new disciplines have entered the research arena. The series now includes reviews on bio­ chemical, biological, immunological, physiological and medicinal aspects of drug research. Researchers actively engaged in the various scientific fields forming the entity of drug research can benefit from the wealth of knowledge and experience of the respective authors, and will be assisted in their endeavour to discover new pharmaceutical agents. Those simply wanting to keep abreast of new developments in the complex, multi-discipline science can turn to the "Progress in Drug Research" volumes as an almost encyclopaedic source of information without having to consult the innumerable original publications. Volume 32 contains 12 reviews, a subject index, an index for the close to 400 articles published in the series so far, and an author and titles index for all 32 volumes. Front Matter....Pages 1-8 Antigen-specific T-cell factors and drug research....Pages 9-20 Implications of immunomodulant therapy in Alzheimer’s disease....Pages 21-42 Behavioral correlates of presynaptic events in the cholinergic neurotransmitter system....Pages 43-130 Surface interaction between bacteria and phagocytic cells....Pages 131-147 The bacterial cell surface and antimicrobial resistance....Pages 149-174 Hypertension: Relating drug therapy to pathogenetic mechanisms....Pages 175-194 Adenosine receptors: Clinical implications and biochemical mechanisms....Pages 195-247 Stereoselective drug metabolism and its significance in drug research....Pages 249-303 Immunostimulation with peptidoglycan or its synthetic derivatives....Pages 305-328 Organizing for drug discovery....Pages 329-375 Approaches to the rational design of bacterial vaccines....Pages 377-409 The chemistry of DNA modification by antitumor antibiotics....Pages 411-498 Back Matter....Pages 499-547