Programmed Cell Death in Cancer Progression and Therapy (Advances in Experimental Medicine and Biology Book 615)

Programmed Cell Death (pcd) Plays Pivotal Roles In Tumor Progression, Cancer Therapeutics And Resistance Of Tumor Cells To Therapy. With The Discovery Of Key Mechanisms That Are Involved In Mediating Pcd And In Promoting Resistance To Therapy, Design Of Therapeutic Approaches For Promoting Tumor-selective Cell Death Has Risen Dramatically. With This Book, We Give A Comprehensive Overview Of The Mechanisms That Are Involved In Mediating And Regulating Pcd In Cancer. We Also Provide A Detailed Indication Of The Utility Of Pcd In Cancer Therapy. This Book Will Be A Valuable Resource For Researchers Investigating The Role Of Pcd In Cancer And Other Diseases, Researchers Investigating The Molecular Mechanism Of Chemotherapeutic Agents And Drug-resistance In Cancer And For Physicians Using Chemotherapeutic Agents. Additionally, This Book Will Be A Important Educational Source For Phd Students Specializing In Cell Biology, Immunology And Md Students Interested In Oncology And Cancer Therapeutics. Cell Death : History And Future / Zahra Zakeri And Richard A. Lockshin -- Caspase Mechanisms / Guy S. Salvesen And Stefan J. Riedl -- The Mitochondrial Death Pathway / Anas Chalah And Roya Khosravi-far -- Apoptotic Pathways In Tumor Progression And Therapy / Armelle Melet ... [et Al.] -- Therapeutic Targeting Of Death Pathways In Cancer : Mechanisms For Activating Cell Death In Cancer Cells / Ting-ting Tan And Eileen White -- Overcoming Resistance To Apoptosis In Cnacer Therapy / Peter Hersey, Xu Dong Zhang, And Nizar Mhaidat -- Trail Receptors : Targets For Cancer Therapy / Robin C. Humphreys And Wendy Halpern -- Rational Design Of Therapeutics Targeting The Bcl-2 Family : Are Some Cancer Cells Primed For Death But Waiting For A Final Push? / Victoria Del Gaizo Moore And Anthony Letai -- Autophagy And Tumor Suppression : Recent Advancesin Understanding The Link Between Autophagic Cell Death Pathways And Tumor Development / Shani Bialik And Adi Kimchi -- Regulation Of Programmed Cell Death By The P53 Pathway / Kageaki Kuribayashi And Wafik S. El-deiry -- Regulation Of Programmed Cell Death By Nf-[kappa]b And Its Role In Tumorigenesis And Therapy / Yongjun Fan ... [et Al.] -- Targeting Proteasomes As Therapy In Multiple Myeloma / Dharminer Chauhan, Teru Hideshima, And Kenneth C. Anderson -- Histone Deacetylase Inhibitors : Mechanisms And Clinical Significance In Cancer : Hdac Inhibitor-induced Apoptosis / Sharmila Shankar And Rakesh K. Srivastava -- Rna Interference And Cancer : Endogenous Pathways And Therapeutic Approaches / Derek M. Dykxhoorn, Dipanjan Chowdhury, And Judy Lieberman -- Cancer Stem Cells And Impaired Apoptosis / Zainab Jagani And Roya Khosravi-far. Roya Khosravi-far, Eileen White. Includes Bibliographical References And Index. Front Matter....Pages i-xiv Cell Death: History and Future....Pages 1-11 Caspase Mechanisms....Pages 13-23 The Mitochondrial Death Pathway....Pages 25-45 Apoptotic Pathways in Tumor Progression and Therapy....Pages 47-79 Therapeutic Targeting of Death Pathways in Cancer: Mechanisms for Activating Cell Death in Cancer Cells....Pages 81-104 Overcoming Resistance to Apoptosis in Cancer Therapy....Pages 105-126 Trail Receptors: Targets for Cancer Therapy....Pages 127-158 Rational Design of Therapeutics Targeting the BCL-2 Family: Are Some Cancer Cells Primed for Death but Waiting for a Final Push?....Pages 159-175 Autophagy and Tumor Suppression: Recent Advances in Understanding the Link between Autophagic Cell Death Pathways and Tumor Development....Pages 177-200 Regulation of Programmed Cell Death by the P53 Pathway....Pages 201-221 Regulation of Programmed Cell Death by NF-κB and its Role in Tumorigenesis and Therapy....Pages 223-250 Targeting Proteasomes as Therapy in Multiple Myeloma....Pages 251-260 Histone Deacetylase Inhibitors: Mechanisms and Clinical Significance in Cancer: HDAC Inhibitor-Induced Apoptosis....Pages 261-298 RNA Interference and Cancer: Endogenous Pathways and Therapeutic Approaches....Pages 299-329 Cancer Stem Cells and Impaired Apoptosis....Pages 331-344 Back Matter....Pages 345-356 Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. This book examines the mechanisms involved in mediating and regulating PCD in cancer. It also provides a detailed indication of the utility of PCD in cancer therapy. The book features chapters on the current and future of RNA interference in therapeutics and Pathways involved in Stem Cell Survival and Death.