Progestins and the Mammary Gland: From Basic Science to Clinical Applications (Ernst Schering Foundation Symposium Proceedings Book 2007)

"Progestins play a key role in reproductive endocrinology and as pharmaceutical drugs for contraception and in combined hormone therapy. To further our understanding of progestin action in the mammary gland, an international symposium, attended by leading researchers from academia and industry, was held in Berlin, 21-23 March 2007. Genetic mouse models helped to elucidate the role of progestins, both in normal breast development and in disease. Mechanistic molecular studies inspired the design of new progestins with improved tissue selectivity. In addition, the clinical impact of progesterone receptor agonists and antagonists for the prevention and treatment of breast cancer was discussed."--Jacket Front Matter....Pages i-xvii Dynamic Regulation of Progesterone Receptor Activity in Female Reproductive Tissues....Pages 25-43 Steroid Receptor Coactivator 2: An Essential Coregulator of Progestin-Induced Uterine and Mammary Morphogenesis....Pages 55-76 Inhibition of Mammary Tumorigenesis by Estrogen and Progesterone in Genetically Engineered Mice....Pages 109-126 Estrogens, Progestins, and Risk of Breast Cancer....Pages 127-150 Mammary Development, Carcinomas and Progesterone: Role of Wnt Signalling....Pages 151-170 Progesterone Signaling in Mammary Gland Development....Pages 175-185 Progesterone Receptor Isoforms in Normal and Malignant Breast....Pages 190-207 In Vivo Characterization of Progestins with Reduced Non-genomic Activity In Vitro....Pages 208-235 In Vitro and In Vivo Characterization of a Novel Nonsteroidal, Species-Specific Progesterone Receptor Modulator, PRA-910....Pages 236-250 O. Conneely, C. Otto, Editors. Includes Bibliographical References.