Progenitor Cell Therapy for Neurological Injury (Stem Cell Biology and Regenerative Medicine)

Annotation There are currently no reparative therapies for severe neurological injury, including brain injury, spinal cord injury and stroke. Actually, most treatments are designed simply to limit secondary damage. However, pre-clinical data supports the idea that exogenous stem and progenitor cells have the potential to promote a reparative response to severe neurological injuries. Progenitor Cell Therapy for Neurological Injury is a compilation of seminal essays that explore many unique aspects of neurological injury, focusing on the critical translational issues of cell delivery. Specifically, it discusses routes of administration, types of progenitor cells (alone and/or in combinations), timing of delivery and adjuncts to promote cell engraftment, survival and effectiveness. In addition, many chapters address measuring the effects of transplanted cells and cell tracking. The paradigms of how cell-based therapeutics affect neurological injury is changing rapidly. The developments in this field may ultimately offer realistic hope for improvement in patients with severe injuries. This book is a vital key toward unlocking those future treatments Front Matter....Pages i-x Basics of Stem and Progenitor Cells....Pages 1-18 Progenitor Cell Tissue Engineering....Pages 19-46 Stem Cell Delivery Methods and Routes....Pages 47-68 Neural Progenitor Cells for Traumatic Brain and Spinal Cord Injury: Endogenous Cell Rescue Versus Replacement Mechanisms....Pages 69-95 Traumatic Brain Injury Pathophysiology/Models....Pages 97-122 Traumatic Brain Injury: Relationship of Clinical Injury to Progenitor Cell Therapeutics....Pages 123-142 Cell-Based Therapy for Stroke....Pages 143-161 Spinal Cord Injury Pathophysiology and Progenitor Cell Therapy....Pages 163-180 Progenitor Cell Therapy for the Treatment of Central Nervous System Injury: A Review of the State of Current Clinical Trials....Pages 181-191 Back Matter....Pages 193-200 Progenitor Cell Therapy for Neurological Injury; Preface; Contents; Contributors; Chapter 1: Basics of Stem and Progenitor Cells; Chapter 2: Progenitor Cell Tissue Engineering; Chapter 3: Stem Cell Delivery Methods and Routes; Chapter 4: Neural Progenitor Cells for Traumatic Brain and Spinal Cord Injury: Endogenous Cell Rescue Versus Replacement Mechanisms; Chapter 5: Traumatic Brain Injury Pathophysiology/Models; Chapter 6: Traumatic Brain Injury: Relationship of Clinical Injury to Progenitor Cell Therapeutics; Chapter 7: Cell-Based Therapy for Stroke