Processing and presentation of antigens [... developed from a P&S Biomedical Sciences Symposium held at Arden House, on the Harriman Campus of Columbia University, from May 30 through June 1, 1986

Processing and Presentation of Antigens brings together the views of immunologists, biochemists, cell biologists, and virologists who have a common interest in the early phases of the immune response. Antigen processing and presentation comprise a series of events that are much more complex and sophisticated than had been thought for a long time, and constitute an essential part of the biology of the immune response to T-dependent protein antigens. The book is organized into seven parts. Part I discusses the major advances and insights in antigen processing, some results on the interaction of antigen with class II MHC molecules, and the precise mechanism involved in antigen processing. Part II presents papers on endosomes, lysosomes, and recycling. Part III deals with studies on presentation in the context of class I MHC molecules. The chapters in Part IV examine interactions of antigens with class II MHC molecules. Part V contains papers on macrophages and dendritic cells as accessory cells. Part VI examines antigen presentation by B cells. Part VII covers studies on T cells. Content: Front Matter , Page iii Copyright , Page iv Preface , Pages xiii-xiv , Benvenuto Pernis, Samuel C. Silverstein, Henry J. Vogel 1 - Processing of Native Antigen by Accessory Cells and Presentation of Membrane-Bound MHC-Associated Antigen to Specific T Cells , Pages 3-11 , BARUJ BENACERRAF, LOUIS D. FALO JR., KENNETH L. ROCK 2 - Pinocytic Flow through Macrophages , Pages 15-27 , JOEL A. SWANSON, SAMUEL C. SILVERSTEIN 3 - Processing of Ligands in Macrophage Endosomes , Pages 29-42 , STEPHANIE DIMENT, BARBARA M. SIMMONS, JOHN H. RUSSELL, PHILIP D. STAHL 4 - Intracellular Transport of Class II HLA Antigens , Pages 43-51 , PETER CRESSWELL, JANICE S. BLUM 5 - Endocytosis of the T4 Molecule , Pages 53-66 , SETH LEDERMAN, JONATHAN BARASCH, DIANE SHERMAN, MAURICE GODFREY, JOHN BELKO, MICHAEL D. GERSHON, LEONARD CHESS 6 - Pathways of Viral Antigen Presentation in T Lymphocyte Recognition , Pages 69-79 , T.J. BRACIALE, L.A. MORRISON, T.J. HENKEL, V.L. BRACIALE 7 - The Epitopes of Influenza Nucleoprotein Recognized by Cytotoxic T Lymphocytes Can Be Defined with Short Synthetic Peptides , Pages 81-85 , A.R.M. TOWNSEND, J. ROTHBARD, F.M. GOTCH, J. BASTIN, G. BAHADUR, D. WRAITH, A.J. MCMICHAEL 8 - Cytotoxic T Cell Recognition of the SV40 Tumor Antigen: A Note of Caution , Pages 87-95 , LINDA R. GOODING, KATHRYN A. O'CONNELL, ROY GEIB, JAMES M. PIPAS 9 - Ia Structure and Immune Recognition , Pages 99-124 , RONALD N. GERMAIN, NED S. BRAUNSTEIN, ROBERT I. LECHLER, JIM MILLER, FRANCA RONCHESE, ANDREA J. SANT 10 - The Role of MHC and Amphipathic Structures in T Cell Recognition: Features Determining Immunodominance , Pages 125-131 , JAY A. BERZOFSKY, KEMP B. CEASE, IRA J. BERKOWER, HANAH MARGALIT, JIM CORNETTE, JOHN SPOUGE, CECILIA SPENCER, GAIL BUCKENMEYER, HOWARD STREICHER, MASAHARU KOJIMA, CHARLES DeLISI 11 - Pathways to Presentation , Pages 133-141 , ELLEN HEBER-KATZ, EIJI WATARI, BERNHARD DIETZSCHOLD 12 - Antigen Presentation by Supported Planar Membranes Containing Purified Major Histocompatibility Complex Proteins , Pages 143-155 , TANIA H. WATTS, HARDEN M. McCONNELL 13 - Antigen Presentation by Macrophages , Pages 159-165 , EMIL R. UNANUE 14 - Antigen Presentation by Dendritic Cells , Pages 167-177 , RALPH M. STEINMAN, KAYO INABA 15 - The Immunologic Properties of Epidermal Langerhans Cells , Pages 179-185 , GEROLD SCHULER, KAYO INABA, MARGIT WITMER, RALPH STEINMAN 16 - V H Gene Expression by Nontransformed Pre-B Cells during Differentiation in Vitro , Pages 187-198 , JOHANNA A. GRIFFIN, DAVID M. SPALDING 17 - The Interaction between Immunogenic Peptides and Ia , Pages 201-213 , HOWARD M. GREY, SØREN BUUS, ALESSANDRO SETTE 18 - On the Role of B Cell Surface Ig in Antigen Presentation to T Cells , Pages 215-219 , ANTONIO LANZAVECCHIA, SANDRO SIERVO, DORIS SCHEIDEGGER 19 - The Role of Specific B Lymphocytes in Antigen Processing and Presentation to T Cells , Pages 221-225 , KENNETH L. ROCK, BARUJ BENACERRAF, ABUL ABBAS 20 - The Role of Membrane Immunoglobulin in Antigen Presentation by B Lymphocytes , Pages 227-234 , DAVID C. PARKER, EDMUND J. GOSSELIN, HANS-PETER TONY 21 - Selective Cooperation between T and B Clones Specific for the Same Macromolecular Antigen: Does Antibody Specificity Influence Antigen Processing? , Pages 235-245 , FRANCO CELADA, ANNALISA KUNKL, DANIELA FENOGLIO, FABRIZIO MANCA 22 - Recycling of Histocompatibility Molecules and Antigen Presentation , Pages 247-259 , BENVENUTO PERNIS 23 - Localization of Immune Receptor Recognition Sites on Major Histocompatibility Molecules through the Analysis of H-2K b Mutants , Pages 263-272 , RICHARD A. ZEFF, P. AJIT KUMAR, JAN GELIEBTER, STANLEY G. NATHENSON 24 - T Cell Recognition of Antigen and Ia Molecules Involves a Trimolecular Complex , Pages 273-290 , JONATHAN D. ASHWELL, BARBARA S. FOX, RONALD H. SCHWARTZ 25 - Antigen-Presenting Cell Lysis: Role in Immune Responses and Effect on Quantitative Analyses of Antigen Presentation to T Cells , Pages 291-299 , BARRY JONES, JAY HOROWITZ, JONATHAN KAYE, LORAN KILLAR, KIM BOTTOMLY, CHARLES A. JANEWAY JR. 26 - Structure–Function Relationship in Human Class I HLA Molecules , Pages 301-313 , JESUS SANTOS-AGUADO, JAMES A. BARBOSA, R ANDREW BIRO, JACK L. STROMINGER Index , Pages 315-324