Proceedings of the Fourth International Symposium on Cyclodextrins: Munich, West Germany, April 20–22, 1988 (Advances in Inclusion Science, 5)

The rapidly growing number of papers and patents on Cyclodextrins and their potential or actual industrial uses raised the idea to organize a Symposium on Cyclodextrins. This Symposium - held in September 1981 in Budapest, with more than 200 participants from 17 countries - proved to be very succesfull in every respect, therefore it has been accepted unanimously to organize the lInd CD-Symposium in 1984, in Tokyo. (The Budapest-Symposium got posteriorly the "First" adjective). The IInd Symposium was held together with the III. Int. Symposium on Chlatrate Compounds and Molecular Inclusion Phenomena. The IIIrd CD-Symposium also was held as a Joint Symposium, with the IVth. Chlatrate Symposium in Lancaster, U. K. ,1986. The limited time however showed, that such a broad field - from calixarenes to zeolites - can not be managed efficiently. Therefore the International Organizing Committee voted for separation of two Symposia in the future. The IVth Int. CD-Symposium was held in the Munich, in April 1988, and the Vth Chlatrate Symposium (called already Vth Int. Symposium on Inclusion Phenomena and Molecular Recognition) was held in Alabama, Sept. 1988. In Munich 220 participants from 21 countries attended 32 verbal lectures and 54 posters. This volume contains the submitted 71 manuscripts of the IVth Cyclodextrin Symposium. Front Matter....Pages i-xi Introductory Remarks....Pages 1-3 Front Matter....Pages 5-5 Enzymology and Molecular Genetics of CD-Forming Enzymes....Pages 7-17 Studies on the Reaction Mechanism of Cyclodextrin Glycosyltransferases: Subsite Analysis....Pages 19-26 Cultural Characteristics of an Cyclomaltodextrin Glucano-Transferase-Producing Alkalophilic Bacillus Sp.....Pages 27-31 Use of Cyclohexane in the Production of Pure alpha - and b eta -Cyclodextrins....Pages 33-39 Cyclodextrins from Potato Starch. Recent Developments.....Pages 41-46 Production of Cyclodextrins Using Immobilized Enzymes....Pages 47-53 Immobilization of Pullulanase and Successive Synthesis of Branched Cyclodextrins by Immobilized Pullulanase....Pages 55-59 The Acid Hydrolysis of Cyclodextrins and Linear Oligosaccharies: a comparative study....Pages 61-63 Isolation and Purification of Gamma-Cyclodextrin by Affinity Chromatography....Pages 65-70 Cloning and Nucleotide Sequence of a Cyclodextrin Glycosyltransferase Gene from the Alkalophilic Bacillus 1-1....Pages 71-76 Expression of the Gene for Cyclodextrin-Glycosyl-Transferase from Klebsiella in E. Coli ....Pages 77-80 Method Development for Economic Production of Cyclodextrins by Means of Ternary Complex Formation....Pages 81-86 Selective Complexing Agents for the Production of γ-Cyclodextrin....Pages 87-92 Front Matter....Pages 93-93 Preparation and N.M.R. Study of Maltooligomers....Pages 95-101 A Chemically Modified Cyclodextrin....Pages 103-111 Methylation of Cyclodextrins Via Phase-Transfer Catalysis....Pages 113-117 Environmental Effects on Molecular Properties of Organic Compounds. Part III. Cyclodextrins with a Schiff Base Moiety....Pages 119-123 The Inclusion Properties of 6-Linked β-Cyclodextrin 1-Thio-β-D-Glycosides....Pages 125-128 Selective Multiple 6-Substitution in Cyclodextrin by Hydrophobic and Hydrophilic Groups....Pages 129-132 Front Matter....Pages 93-93 Inclusion Properties of Hydrophobic Derivatives of Cyclodextrins (CDs)....Pages 133-138 Cyclodextrin — Cellulose Copolymers....Pages 139-143 Characterization of Cyclodextrin Derivatives by the Reductive-Cleavage Method....Pages 145-149 Modified Cyclodextrins; Substitution at O3 and Complexation of Metals....Pages 151-155 Front Matter....Pages 157-157 Chemical and Physical Studies on Cyclodextrin Inclusion Compounds....Pages 159-164 Preparation and 13 C NMR Identification of Solid Cyclodextrin Inclusion Compounds....Pages 165-171 Inclusion Compounds in Water. Interaction of α-Cyclodextrin with UREA Derivatives at 25°C....Pages 173-179 Dynamic Aspects of Molecular Inclusion Reactions by Cyclodextrins....Pages 181-187 Interaction of Cyclodextrins with Glycolipids. 1 H-NMR Studies....Pages 189-195 Chemically-Modified Cyclodextrins as Second Sphere Ligands for Transition Metal Complexes....Pages 197-203 Some Interesting Aspects in 1 H-NMR Spectroscopy by Cyclodextrin Complexation....Pages 205-208 Molecular Inclusion Reaction of Charged Cyclodextrins....Pages 209-213 Inclusion Complexes of Naphthols with Cyclodextrins in Aqueous Solution. A 1 H-NMR Study....Pages 215-219 IR-Spectroscopic Measurement of the p-Nitrophenol - β-Cyclodextrin Equilibrium in Aqueous Solution....Pages 221-225 Complexes of Insoluble Cyclodextrin Polymers....Pages 227-235 Methods for Characterization of the Wettability of Cyclodextrin Complexes....Pages 237-241 Detailed Structure of an α Cyclodextrin-Cyclopentanone Clathrate by Neutron Diffraction....Pages 243-246 Influence of Ethanol on the Complexation of Isomeric Chloronitrobenzenes by β -Cyclodextrin....Pages 247-252 Charaterisation of β-Cyclodextrin Complexes....Pages 253-261 Front Matter....Pages 263-263 New Trends in Pharmaceutical Applications of Cyclodextrin Inclusion Compounds....Pages 265-275 Front Matter....Pages 263-263 Menadione Inclusion Compounds with Mixtures of Natural Cyclodextrins....Pages 277-283 Interactions between Cyclodextrins and Some Antimycotic Imidazole Derivatives: Studies on Solubility and Antimicrobial Activity....Pages 285-291 Increasing the Solubility Characteristics of Iomeglamic Acid with β -Cyclodextrin....Pages 293-298 The Inclusion Complex of Tolbutamide with Maltosyl(G 2 )- β-Cyclodextrin in Aqueous Solution and in the Solid State....Pages 299-306 Complexation of Polyene Antibiotics with γ-Cyclodextrin....Pages 307-312 The Effect of Cyclodextrins on the Mitomycin Stability in Acidic Aqueous Media....Pages 313-317 Assessment of the Stoichiometry of a Vinburnine and Gammacyclodextrin Complex by Microcalorimetry....Pages 319-323 Molecular Encapsulation of Retinoic Acid by β -Cyclodextrin, Characterization of the Inclusion Compound....Pages 325-328 Solubility Enhancement of Ipriflavone by Cyclodextrin Complexation....Pages 329-335 The Effect of Beta-Cyclodextrin Complexation on Plasma Levels of Ipriflavone and its Main Metabolites....Pages 337-341 The Comparison of Absorption, Distribution and Elimination of Ipriplavone-14C and Ipriplavone-14C-Beta-Cyclodextrin Inclusion Complex....Pages 343-347 The Influence of Inclusion by Cyclodextrins on Absorption Kinetics of Dantrolene in the Rat....Pages 349-353 Improvement on Photostability of Several Essential Oils and Menadione by Natural Cyclodextrins....Pages 355-358 Bitterness Reduction with Beta-Cyclodextrin....Pages 359-366 Front Matter....Pages 367-367 Cyclodextrin Derivatives for Solubilisation, Stabilisation, and Absorption of Drugs....Pages 369-382 Biomedical Uses of Amorphous Water Soluble Derivatives of Cyclodextrins....Pages 383-391 Highly Soluble ß-Cyclqdextrin Derivatives, a Comparative Study....Pages 393-398 Water Soluble Complexes of a Brain-Targeted Drug Delivery System....Pages 399-405 Pharmacokinetics of Dimethyl-Beta-Cyclodextrin in Rats....Pages 407-413 Percutaneous Absorption of Heptakis-(2,6-Di-O- 14 C-Methyl)-β -Cyclodextrin in Rats....Pages 415-420 Front Matter....Pages 367-367 Investigation of the Hemolytic Effect of the Cyclodextrin Derivatives....Pages 421-425 Determination of Hydroxypropyl-β-Cyclodextrin in Plasma and Urin by Size Exclusion Chromatography with Post Column Complexation....Pages 427-433 Front Matter....Pages 435-435 Cyclodextrins in Analytical Chemistry....Pages 437-449 Cyclodextrins in Chromatography and Isotachophoresis....Pages 451-463 Enantioselective Capillary Gas Chromatography with Modified Cyclodextrins as Chiral Stationary Phases....Pages 465-471 HPLC of Chloramphen Icol and Some of its Synthetic Intermediates on a Cyclo Dextrin-BonDed Chiral Stationary Phase....Pages 473-477 GC Capillary Columns with Cyclodextrins as Stationary Phases....Pages 479-483 Fluorescence Studies of Cyclodextrin Complexes....Pages 485-491 Immobilized Cyclodextrins for Affinity Chromatography....Pages 493-496 Gelchromatographic Separation of Proteins on Cyclodextrin Bead Polymers....Pages 497-501 β -Cyclodextrin in Optical Resolution of Chiral Sulphinyl Derivatives....Pages 503-507 Catalytic Activity of Artificial Hydrolases Using Modified Cyclodextrins....Pages 509-512 Functionalized Cyclodextrins as Oxydo-Reductasic Enzyme Models....Pages 513-517 Selective Reductions of CD Complexed Terpenes....Pages 519-523 Reactions in the Presence of Cyclodextrins....Pages 525-530 Front Matter....Pages 531-531 Application of Cyclodextrins to Foods, Toiletries and Other Products in Japan....Pages 533-543 Long Term Storage Stability Studies on Flavour- β -Cyclodextrin Complexes....Pages 545-549 Application o Beta Cyclodextrin in Meat Industry....Pages 551-555 Effect of Cyclodextrin and Glycerolmonostearate on Starch Gelatinization....Pages 557-560 Fungicidal Activity of Benomyl in Presence of β-Cyclqdextrin....Pages 561-567 Back Matter....Pages 569-576