Probiotic Research in Therapeutics : Volume 1: Applications in Cancers and Immunological Diseases

The volume sheds new light on role of gut dysbiosis in cancer and immunological diseases and their clinical manifestations. Contributions in the volume discuss about the gut microbiota as a therapeutic target and the role of probiotics in its management. The volume explores application of probiotics in the treatment of various cancers viz. colorectal, gastric, lung, and breast cancer and immunological diseases. The volume comprises of chapters from expert contributors organized into various important themes which include, introduction, relationship between gut microbiota and disease condition, mechanisms involved, clinical and in vivo status, conclusion and future directions. This is a highly informative and carefully presented book, providing recent and innovative insight for scholars and researchers with an interest in probiotics and its applications in cancer and immunological diseases. Volume 1 sheds new light on role of gut dysbiosis in cancer and immunological diseases and their clinical manifestations. Contributions in the volume discuss about the gut microbiota as a therapeutic target and the role of probiotics in its management. The volume explores application of probiotics in the treatment of various cancers viz. colorectal, gastric, lung, and breast cancer and immunological diseases. The volume comprises of chapters from expert contributors organized into various important themes which include, introduction, relationship between gut microbiota and disease condition, mechanisms involved, clinical and in vivo status, conclusion and future directions. This is a highly informative and carefully presented book, providing recent and innovative insight for scholars and researchers with an interest in probiotics and its applications in cancer and immunological diseases. Volume 2: In a normal physiological state, several bacteria are present in the human gut that is essential to maintain the normal to healthy gastrointestinal function. Disturbances in this "normal flora" lead to gut inflammation and infection. This volume explores the potential of probiotics, the healthy bacteria, to manage gut-related diseases including gastrointestinal cancers, ulcerative colitis, H. pylori infections, and diarrhea; vaginosis; oral health; airway inflammation; and atopic dermatitis. The concept of designer probiotics, edible vaccines and future scope of research in the field is also presented. The animal models used for studying the benefits of probiotics in gut inflammation are described for beginners. Volume 3: Recent research in science establishes a direct relation between human gut and skin. Several species of live microbes inhabit the human skin and intestines which far outnumbers the mammalian cells in the human body. Research interest of Nextgen scientists is focused on beneficially harnessing this microbial population to address skin disorders like acne, rosacea, eczema, premature aging, and skin cancer which are established to be a result of skin-microbiome dysbiosis. This volume highlights evidence-based endeavours of the scientific community in this sector. Currently there is no concrete literature which gives a detailed vision on the relationship between gut microbiota and skin related disorders. This volume is an attempt to put together available data in the area and demonstrate usefulness of probiotics as a new therapeutic option for management of these skin diseases which currently show poor prognosis, high cost of treatment and compromised quality of life of the patient. Volume 4: Humans have numerous microorganisms residing in the body, especially in the gut, far exceeding the human body's normal mammalian cells. Recent research links the gut microbiome, the population of microorganisms living in the gastrointestinal tract, with brain diseases. This volume explores the concept and possibility of its extension to manage a galaxy of CNS diseases, including Parkinson's, Alzheimer's, Autism spectrum disorders, depression, insomnia, and chronic fatigue syndrome. This volume elaborates about communication channels between gut and brain via the vagus nerve, short-chain fatty acids including omega acids, and other inflammasomes. In contrast to the available books on the topic, this title is more versatile and endeavors to bring together scientific pre-clinical, and clinical claims on the probable psychobiotic implication of probiotic therapy. The book will appeal similar to the general public, students, experienced researchers, and academicians. It is endeavored to address an aspect of probiotic usage beyond gut disorders. We hope that it would be helpful to people studying the human nervous system and related conditions with their treatments Front Matter ....Pages i-xiv Gut Microbiota and Cancer Correlates (Alok Malaviya, K. A. Paari, Shruti Malviya, Vamsi Krishna Kondapalli, Aditi Ghosh, Riya Ann Samuel)....Pages 1-27 Potential Preventive and Therapeutic Accountability of Probiotics in Cancer: An Insight of Mechanism of Action (Pranav Kumar Prabhakar, Yachana Mishra, Vijay Mishra)....Pages 29-45 Probiotics and Cancer: Boosting the Immune System (Prashant Upadhaya, Prachi Kharkar, Abhinandan Patil, Shivaji Pawar, John Disouza, Vandana B. Patravale)....Pages 47-67 Probiotics as Next Generation Strategy for Cancer Therapy (Anuradha Mishra, Pragyandip P. Dash, Afreen Usmani, Satya Prakash Singh, Anup K. Sirbaiya)....Pages 69-94 Metabiotics in Colorectal Cancer: Crosstalk Between Gut Microbiota and Host Pathology (Monica Gulati, Sachin Kumar Singh, Rajesh Kumar, Kamal Dua, Simanchal Panda, James Blaxland et al.)....Pages 95-112 Possibility of Probiotic in Colorectal Cancer: A Specific Countenance to Research (Mohammad Yasir, Ruchi Khare, Pushpendra Singh, Sohni Singh, Rahul Shrivastava)....Pages 113-123 Probiotics in Lung Cancer: An Emerging Field of Multifarious Potential and Opportunities (Mallesh Kurakula, Koteswara Rao G. S. N.)....Pages 125-158 Probiotics for Prophylaxis and Management of Breast Cancer: Preclinical and Clinical Evidence (Sheyda Ranjbar, Seyed Afshin Seyednejad, Shahab Edalatian Zakeri, Hossein Rezaeizadeh, Roja Rahimi)....Pages 159-189 Probiotics for Management of Gastrointestinal Cancers (Nilesh Rai, Anurag Kumar Singh, Priyanka Kumari Keshri, Suvakanta Barik, Swapnil C. Kamble, Santosh Kumar Singh et al.)....Pages 191-209 Potential of Probiotics in the Management of Lung Cancer (G. Divyashri, T. P. Krishna Murthy, Manikanta Murahari)....Pages 211-230 Bacteriocins of Probiotics as Potent Anticancer Agents (Pallvi Sharma, Santosh Kumar Tiwari)....Pages 231-250 Probiotics in Autoimmune and Inflammatory Diseases (Vivek P. Chavda, Hitesh Prajapati, Punit Zadafiya, Moinuddin Soniwala)....Pages 251-271 Role of Probiotics in Rheumatoid Arthritis (Rahul Shukla, Munindra Ruwali, N. Sharath Pawar, S. J. S. Flora)....Pages 273-294 Genetically Engineered Probiotics (Saba Hag, Naresh Poondla)....Pages 295-328 A Glance to the Patent World of Probiotics (Vivek P. Chavda, Arumugam Meyyappan, Disha Chavda, Moinuddin Soniwala)....Pages 329-367