Principles and practice of lung cancer : the official reference text of the International Association for the Study of Lung Cancer (IASLC)

Thoroughly revised and updated, this Fourth Edition is the most comprehensive, current reference on lung cancer, with contributions from the world's foremost surgeons, radiation oncologists, medical oncologists, pulmonologists, and basic scientists. Coverage includes complete information on combined modality treatments for small cell and non-small cell lung cancer and on complications of treatment and management of metastases. Emphasis is also given to early detection, screening, prevention, and new imaging techniques. This edition has expanded thoracic oncology chapters including thymus, mesothelioma, and mediastinal tumors, more detailed discussion of targeted agents, and state-of-the-art information on newer techniques in radiotherapy. Other highlights include more international contributors and greater discussion of changes in lung cancer management in each region of the world. A new editor, Giorgio Scagliotti, MD from the University of Turin, has coordinated the accounts of European activities. A companion website includes the full text online and an image bank. Preface Contributors SECTION 1: Lung Cancer Epidemiology 1: The Etiology and Epidemiology of Lung Cancer 2: The Tobacco Epidemic 3: Nontobacco-Related Lung Carcinogenesis 4: Genetic Susceptibility to Lung Cancer SECTION 2: Lung Cancer Biology 5: An Overview of the Molecular Biology of Lung Cancer 6: Genomic Alterations in Lung Cancer 7: Epigenetic Changes in Lung Cancer: Pathobiological and Clinical Aspects 8: Molecular Events Surrounding the Angiogenic Switch of Lung Cancer 9: Applications of Proteomics to the Management of Lung Cancer. 10: Molecular Prognostication of Lung Cancer11: Examining the Cancer Stem Cell Hypothesis in Human Lung Cancers 12: Lung Cancer and Its Microenvironment 13: Mouse Models of Lung Cancer 14: Cell Cycle and Vascular Targets for Radiotherapy SECTION 3: Screening and Prevention 15: Population-Based Lung Cancer Prevention: An Overview 16: Screening for Lung Cancer 17: Low-Dose Computed Tomography Screening: Experiences from the Randomized Population-Based Nelson Screening Trial 18: Fine-Needle Aspiration Cytology of Benign and Malignant Tumors of the Lung. 19: Early Detection of Lung Cancer Using Bronchoscopy20: Evolving Early Detection Modalities in Lung Cancer Screening 21: Molecular Carcinogenesis and Chemoprevention of Lung Cancer SECTION 4: Pathology 22: Molecular and Cellular Pathology of Lung Cancer SECTION 5: Presentation, Diagnosis, and Staging 23: Clinical Presentation of Non-Small Cell Carcinoma of the Lung 24: Clinical Presentation of Small Cell Lung Cancer 25: Gender-Related Differences in Lung Cancer 26: Conventional Imaging of Non-Small Cell Lung Cancer 27: Positron Emission Tomography in Lung Cancer. 28: Bronchoscopy in the Diagnosis and Evaluation of Lung Cancer29: Surgical Evaluation of the Mediastinum 30: The International Staging System for Lung Cancer SECTION 6: Surgical Management of Lung Cancer 31: Minimally Invasive Techniques for the Management of Lung Cancer 32: Extent of Resection for Stage I Lung Cancer 33: Management of Ground-Glass Opacity Lesions 34: Management of Stage II Non-Small Cell Lung Cancer and Pancoast Tumors 35: Vertebral Body Resection 36: Surgical Management of Second Primary and Metastatic Lung Cancer. 37: Percutaneous Therapeutic Technologies for Medically Inoperable Lung Cancer38: Surgical Management of Small Cell Lung Cancer 39: Complications of Surgery for Lung Cancer SECTION 7: Radiation Therapy and Lung Cancer 40: Physical Basis of Modern Radiotherapy: Dose and Volume 41: Biological Basis of Fractionation and Timing of Radiotherapy 42: Radiotherapy for Locally Advanced Lung Cancer: Stages IIIA and IIIB 43: Stereotactic Techniques for Lung Cancer Treatment 44: Radiation Treatment-Related Lung Damage SECTION 8: Chemotherapy and Lung Cancer.