Preparation of Compounds Labelled with Tritium and Carbon: 14 for Application in Life Sciences

Compounds labeled with carbon-14 and tritium are indispensable tools for research in biomedical sciences, discovery and development of pharmaceuticals and agrochemicals. Preparation of Compounds Labeled with Tritium and Carbon-14 is a comprehensive, authoritative and up-to-date discussion of the strategies, synthetic approaches, reactions techniques, and resources for the preparation of compounds labeled with either of these isotopes. A large number of examples are presented for the use of isotopic sources and building blocks in the preparation of labeled target compounds, illustrating the range of possibilities for embedding isotopic labels in selected moieties of complex structures. Topics include: Formulation of synthetic strategies for preparing labeled compounds Isotope exchange methods and synthetic alternatives for preparing tritiated compounds In-depth discussion of carbon-14 building blocks and their utility in synthesis Preparation of enantiomerically pure isotopically labeled compounds Applications of biotransformations Preparation of Compounds Labeled with Tritium and Carbon-14 is an essential guide to the specialist strategies and tactics used by chemists to prepare compounds tagged with theradioactive atoms carbon-14 and tritium. Compounds tagged with carbon14 and tritium are critical tools in research in biomedical sciences, discovery, and development of pharmaceuticals and agrochemicals, and investigations into the nature of chemical reactions and the ways living organisms incorporate and modify biological components. A must for scientists, technicians, synthetic organic chemists, and radiochemists, Preparation of Compounds Labelled with Tritium and Carbon14 for Application in Life Sciences is a comprehensive, authoritative, and up-to-date guide to the specialist strategies and tactics used by chemists to prepare com * Compounds tagged with carbon-14 and tritium are critical tools in research and investigations into the nature of chemical reactions and the ways living organisms incorporate and modify biological components. * The first such coverage of these topics for more than three decades.