Prefoldins: the new chaperones (Advances in Experimental Medicine and Biology Book 1106)

This book reviews recent work on molecular chaperones of the prefoldin family from their discovery in Archaea to the basic clarification of their structure. Even though, there is still a lot to investigate in order to understand the roles and functions of prefoldins, some preliminary work suggests their contribution in assembly and activation of a variety of macromolecular complexes. Hence, the reader is introduced to recent structural findings via cryo-electron microscopy and to the importance of this particular group of proteins in health and disease. This book also discusses the particular structure of the URI prefoldin-like complex. In addition, recent developments in the generation of URI mouse models speculate on the functions and emerging roles of the URI prefoldin-like complex in various cellular processes. This novel protein complex represents a unique cellular machinery, which molecular basis of its activity still remains to be determined. This work is thus a guide to help researchers in the field to have a more comprehensive and critical view of the prefoldin world. Front Matter ....Pages i-ix Functional Contributions of Prefoldin to Gene Expression (Laura Payán-Bravo, Xenia Peñate, Sebastián Chávez)....Pages 1-10 Prefoldins in Archaea (Samuel Lim, Dominic J. Glover, Douglas S. Clark)....Pages 11-23 Role of the PAQosome in Regulating Arrangement of Protein Quaternary Structure in Health and Disease (Marie-Soleil Gauthier, Philippe Cloutier, Benoit Coulombe)....Pages 25-36 The Multiple Functions of the PAQosome: An R2TP- and URI1 Prefoldin-Based Chaperone Complex (Jeffrey Lynham, Walid A. Houry)....Pages 37-72 Advances on the Structure of the R2TP/Prefoldin-like Complex (Hugo Muñoz-Hernández, Mohinder Pal, Carlos F. Rodríguez, Chrisostomos Prodromou, Laurence H. Pearl, Oscar Llorca)....Pages 73-83 Role of the Unconventional Prefoldin Proteins URI and UXT in Transcription Regulation (Phillip A. Thomas, Paolo Mita, Susan Ha, Susan K. Logan)....Pages 85-94 Roles and Functions of the Unconventional Prefoldin URI (Almudena Chaves-Pérez, Sebastian Thompson, Nabil Djouder)....Pages 95-108 The Yeast Prefoldin Bud27 (Verónica Martínez-Fernández, Ana Isabel Garrido-Godino, Abel Cuevas-Bermudez, Francisco Navarro)....Pages 109-118 Structure and Function of the Cochaperone Prefoldin (Rocío Arranz, Jaime Martín-Benito, José M. Valpuesta)....Pages 119-131 Back Matter ....Pages 133-135