Prediction of Protein Structures, Functions and Interactions [ISBN : 9780470517673] [Copyright Year : 2009] [Hardcover]

The growing flood of new experimental data generated by genome sequencing has provided an impetus for the development of automated methods for predicting the functions of proteins that have been deduced by sequence analysis and lack experimental characterization. Prediction of Protein Structures, Functions and Interactions presents a comprehensive overview of methods for prediction of protein structure or function, with the emphasis on their availability and possibilities for their combined use. Methods of modeling of individual proteins, prediction of their interactions, and docking of complexes are put in the context of predicting gene ontology (biological process, molecular function, and cellular component) and discussed in the light of their contribution to the emerging field of systems biology. Topics covered include: first steps of protein sequence analysis and structure prediction automated prediction of protein function from sequence template-based prediction of three-dimensional protein structures: fold-recognition and comparative modelling template-free prediction of three-dimensional protein structures quality assessment of protein models prediction of molecular interactions: from small ligands to large protein complexes macromolecular docking integrating prediction of structure, function, and interactions Prediction of Protein Structures, Functions and Interactions focuses on the methods that have performed well in CASPs, and which are constantly developed and maintained, and are freely available to academic researchers either as web servers or programs for local installation. It is an essential guide to the newest, best methods for prediction of protein structure and functions, for researchers and advanced students working in structural bioinformatics, protein chemistry, structural biology and drug discovery. The basics of protein sequence analysis / Katarzyna H. Kaminska, Kaja Milanowska, Janusz M. Bujnicki First steps of protein structure prediction / Karolina Majorek ... [et al.] Automated prediction of protein function from sequence / Meghana Chitale, Troy Hawkins, Daisuke Kihara Template based prediction of three-dimensional protein structures : fold recognition and comparative modeling Template-free predictions of three-dimensional protein structures : from first principles to knowledge-based potentials / D. Gront ... [et al.] Quality assessment of protein models / Bjorn Wallner and Arne Elofsson Prediction of molecular interactions from 3D-structures : from small ligands to large protein complexes / Kengo Kinoshita, Hidetoshi Kono, and Kei Yura Structure-based prediction of enzymes and their active sites / James W. Torrance and Janet M. Thornton The prediction of macromolecular complexes by docking / Sjoerd J. de Vries, Marc van Dijk, and Alexandre M.J.J. Bonvin Protein function prediction via analysis of interactomes / Elena Nabieva and Mona Singh Integrating prediction of structure, function, and interactions / Michael Tress ... [et al.]. Front Matter......Page 1 01.pdf......Page 12 The Basics of Protein Sequence Analysis......Page 14 First Steps of Protein Structure Prediction......Page 52 Automated Prediction of Protein Function from Sequence......Page 76 Template Based Prediction of Three-dimensional Protein Structures: Fold Recognition and Comparative Modeling......Page 99 Template-free Predictions of Three-dimensional Protein Structures: From First Principles to Knowledge-based Potentials......Page 129 Quality Assessment of Protein Models......Page 154 Prediction of Molecular Interactions from 3D-structures: From Small Ligands to Large Protein Complexes......Page 169 Structure-based Prediction of Enzymes and Their Active Sites......Page 197 The Prediction of Macromolecular Complexes by Docking......Page 220 Protein Function Prediction via Analysis of Interactomes......Page 240 Integrating Prediction of Structure,Function, and Interactions......Page 268 Index......Page 289 The prediction of protein structure and function is an increasingly important discipline used by the pharmaceutical industry to help researchers select and understand drug targets and refine drug candidates. Prediction of Protein Structures, Functions, and Interactions presents a comprehensive overview of methods for prediction of protein structure or function, with the emphasis on their availability and possibilities for their combined use. It is an essential guide to the newest, best methods for prediction of protein structure and functions, for researchers and advanced students "Prediction of Protein Structures, Functions, and Interactions presents a comprehensive overview of methods for prediction of protein structure or function, with the emphasis on their availability and possibilities for their combined use. It is an essential guide to the newest, best methods for prediction of protein structure and functions, for researchers and advanced students."--BOOK JACKET