Posttranslational Covalent Modifications of Proteins. International Conference, Oklahoma City, Okla. 1982

Posttranslational Covalent Modifications of Proteins focuses on the processes involved in the regulation of protein functions. Partitioned into 21 chapters, the book starts with discussions on the perspectives and prospectives of posttranslational protein modifications; protein phosphorylation and neural and hormonal control of enzymes; and research on the Rous sarcoma virus. The text also looks at studies on phosphorylation, protein kinases, and protein acetylation. The studies show the different reactions of proteins when combined under varying conditions and controlled environments. Schematic representations are presented to validate the processes involved. The book also presents experiments done on Vitamin K-dependent carboxylase from rat liver and cow. Lengthy discussions and diagrams are presented to give credence to the methodologies and results obtained. The text also focuses on studies on enzymatic activities in bacterial toxins and animals tissues. The book is a vital source of data for readers interested in the processes, techniques, and methodologies involved in the modification of proteins. Content: Inside Front Cover , Page ii Front Matter , Page iii Copyright , Page iv Dedication , Page v Contributors , Pages ix-xii Foreword , Page xiii , William G. Thurman Preface , Page xv , B. Connor Johnson List of Speakers , Pages xvii-xviii POSTTRANSLATIONAL PROTEIN MODIFICATIONS: PERSPECTIVES AND PROSPECTIVES , Pages 1-17 , Finn Wold PROTEIN PHOSPHORYLATION AND THE NEURAL AND HORMONAL CONTROL OF ENZYME ACTIVITY , Pages 19-38 , P. Cohen, A. Aitken, Z. Damuni, B.A. Hemmings, T.S. Ingebritsen, P.J. Parker, C. Picton, T. Resink, A.A. Stewart, N.K. Tonks, J. Woodgett THE ROUS SARCOMA VIRUS TRANSFORMING GENE PRODUCT: IN VITRO PHOSPHORYLATION WITH ATP AND GTP AS PHOSPHATE DONORS, , Pages 39-59 , Yosef Graziani, Eleanor Erikson, Raymond L. Erikson CALMODULIN MODULATED PROTEIN PHOSPHORYLATION , Pages 61-80 , Claude B. Klee, Dianne L. Newton CHARACTERIZATION OF NEURAL-SPECIFIC cAMP-DEPENDENT PROTEIN KINASE , Pages 81-104 , Charles S. Rubin, Dwijen Sarkar, Jill C. Stein, Jack Erlichman PHOSPHOLIPID TURNOVER AS TRANSMEMBRANE SIGNALLING FOR PROTEIN PHOSPHORYLATION AND PLATELET ACTIVATION , Pages 105-123 , Kimihiko Sano, Kozo Kaibuchi, Masahiko Hoshijima, Junji Yamanishi, Ushio Kikkawa, Yoshimi Takai, Yasutomi Nishizuka HISTONE H1 PHOSPHORYLATION: PURIFICATION AND GENERAL PROPERTIES OF A cAMP INDEPENDENT HISTONE H1 KINASE , Pages 125-142 , C. Quirin-Stricker H1 HISTONE PHOSPHORYLATION: AN ANALYSIS OF DIFFERENT PHOSPHORYLATION SITES AND THEIR RELATIONSHIP TO CHROMOSOME REPLICATION , Pages 143-157 , Philip Hohmann EFFECTS OF PHOSPHORYLATION ON THE RECYCLING OF EUKARYOTIC INITIATION FACTOR 2 (eIF-2) , Pages 159-179 , Rosemary Jagus AFFINITY PROBES FOR PROTEIN ACETYLATION AND PHOSPHORYLATION , Pages 181-203 , Vincent G. Allfrey, Richard Sterner, Irene Y.C. Sun VITAMIN K-DEPENDENT CARBOXYLASE FROM RAT LIVER , Pages 205-229 , Jean-Marie Girardot, Jolanta M. Kanabus-Kaminska, B. Connor Johnson STUDIES ON VITAMIN K-DEPENDENT CARBOXYLASE FROM THE COW , Pages 231-251 , C. Vermeer, B.A.M. Soute, M. de Metz VITAMIN K-DEPENDENT CARBOXYLASE: RECENT STUDIES OF THE RAT LIVER ENZYME SYSTEM , Pages 253-279 , J.W. Suttie, P.C. Preusch, J.J. McTigue UTILIZING SUBSTRATES WITH MODIFIED GLUTAMYL RESIDUES TO ELUCIDATE THE REACTION MECHANISM OF THE VITAMIN K-DEPENDENT γ-GLUTAMYL CARBOXYLASE , Pages 281-294 , Paul A. Friedman, David L. Anton, Stephen K. Kwan VITAMIN K-DEPENDENT CARBOXYLASE: A HEME PROTEIN? , Pages 295-319 , Robert E. Olson, Anne L. Hall, Florence C. Lee, William K. Kappel, Robert G. Meyer, William J. Bettger ADP-RIBOSYLATION OF PROTEINS: AN OVERVIEW , Pages 321-327 , Martha Vaughan, Joel Moss NAD:ARGININE ADP-RIBOSYLTRANSFERASES: ENZYMATIC ACTIVITIES IN ANIMAL CELLS AND BACTERIAL TOXINS , Pages 329-342 , Joel Moss, Martha Vaughan MONO- AND POLY(ADP-RIBOSYLATION) IN INTACT CELLS , Pages 343-358 , Myron K. Jacobson, D. Michael Payne, Elaine L. Jacobson PROTEIN ADP-RIBOSYLATION IN RESPONSE TO DNA DAMAGE: EFFECTS OF Mg 2+ AND Ca 2+ ON AUTO ADP-RIBOSYLATION , Pages 359-371 , Nathan A. Berger, Barbara A. Booth, Shirley J. Petzold, James L. Sims ADP-RIBOSYLATION OF THE REGULATORY COMPONENTS OF ADENYLATE CYCLASE, , Pages 373-395 , Richard A. Kahn, Toshiaki Katada, Gary M. Bokoch, John K. Northup, Alfred G. Gilman MACROMOLECULAR PROPERTIES OF POLY(ADP-RIBOSE) AND THE REGULATION OF ITS BIOSYNTHESIS AND DEGRADATION IN PERMEABILIZED RAT BRAIN 9L-GLIOSARCOMA CELLS , Pages 397-416 , Ernest Kun Index , Pages 417-424