Portal hypertension VI : proceedings of the Sixth Baveno Consensus Workshop : stratifying risk and individualizing care

This book will be an excellent tool for practitioners seeking an update on the latest developments in the diagnosis and management of cirrhosis and portal hypertension. Among the topics addressed are risk stratification, prognosis, screening and surveillance, impact of etiological and antifibrotic therapy, the gut microbiome and cirrhosis, prevention of decompensation/further decompensation, management of the acute bleeding episode, controversies in pediatrics, and vascular diseases of the liver in cirrhotic and noncirrhotic portal hypertension. The book is a compilation of lectures and important consensus statements from the Sixth Baveno International Consensus Workshop on Portal Hypertension, the most recent of a series of workshops held every 5 years for hepatologists with an interest in the field. Portal Hypertension VI will serve as a reference book for clinical and research fellows in Gastroenterology and Hepatology and should inspire new research projects in the areas identified as promising by the experts of the Baveno VI Faculty. Front Matter....Pages i-xxi Front Matter....Pages 1-1 Introduction: Baveno I to Baveno VI.... and Beyond....Pages 3-7 The Concept of Risk Stratification....Pages 9-18 Competing Risks and Prognostic Stages in Cirrhosis....Pages 19-28 Front Matter....Pages 29-29 Results of the Questionnaire....Pages 31-37 Identifying Compensated Advanced Chronic Liver Disease: When (Not) to Start Screening for Varices and Clinically Significant Portal Hypertension....Pages 39-49 How to Screen?....Pages 51-62 When and How to Perform Surveillance....Pages 63-72 Cost Considerations....Pages 73-76 Consensus Statements: Session 1—Screening and Surveillance....Pages 77-80 Front Matter....Pages 81-81 (Pre)Primary Prophylaxis: Where Were We and Where Are We Heading?....Pages 83-87 Defining Clinical Hints to Predict Decompensation and Altering Paradigm in Patients with Cirrhosis....Pages 89-97 Antiviral Treatments and Residual Risk of Hepatic Decompensation....Pages 99-104 Etiological Treatments: Lifestyle Management....Pages 105-110 Liver Fibrosis: What Is Reversible and What Not? How to Assess Regression?....Pages 111-115 Potential Antifibrotic Therapies: Approaching the Bedside: Proof-of-Concept Studies (Part 1)....Pages 117-126 New Targets in Therapy: Statins, Antioxidants and Antiangiogenic Strategies....Pages 127-133 Consensus Statements: Session 2—Impact of Etiological and Anti-fibrotic Therapy....Pages 135-136 Front Matter....Pages 137-137 The Gut Microbiome and Cirrhosis: Basic Aspects....Pages 139-168 The Gut Microbiome and Cirrhosis: Clinical Aspects....Pages 169-184 Front Matter....Pages 185-185 Result of the Questionnaire....Pages 187-194 Front Matter....Pages 185-185 Introduction: Prevention of Decompensation Versus Prevention of First Bleeding....Pages 195-204 Role of Comorbidities in the General Management of Compensated Cirrhosis, Including Malnutrition....Pages 205-214 Primary Prophylaxis of First Variceal Bleeding....Pages 215-224 Endoscopic Band Ligation in Primary Prophylaxis....Pages 225-234 Consensus Statements: Changing Scenarios: Prevention of Decompensation....Pages 235-238 Front Matter....Pages 239-239 Management of Acute Variceal Bleeding in Patients with Cirrhosis: General Management, Drug Therapy, and Endoscopic Treatment....Pages 241-259 A la Carte Treatment of Acute Variceal Bleeding....Pages 261-279 Consensus Statements: Management of the Acute Bleeding Episode....Pages 281-285 Front Matter....Pages 287-287 Portal Hypertension in Pediatrics: Controversies and Challenges 2015 Report....Pages 289-300 Front Matter....Pages 301-301 Introduction and Survey Results....Pages 303-309 Prevention of Variceal Rebleeding: Stratifying Risk and Individualizing Care....Pages 311-316 Secondary Prophylaxis in Special Patient Populations....Pages 317-332 Effect of Current Therapies Aimed at Preventing Variceal Rebleeding on Other Complications of Cirrhosis....Pages 333-339 Impact of Treatment of Non-bleeding Complications of Cirrhosis on the Risk of Variceal Bleeding....Pages 341-353 Issues in Trial Design and Areas Needing Further Research....Pages 355-363 Consensus Statements: Preventing Recurrent Variceal Hemorrhage and Other Decompensating Events....Pages 365-367 Front Matter....Pages 369-369 Results of the Questionnaire....Pages 371-376 Extrahepatic Portal Vein Obstruction (EHPVO) and Idiopathic Portal Hypertension: East Versus West....Pages 377-395 Budd-Chiari Syndrome/Hepatic Venous Outflow Tract Obstruction: East vs West....Pages 397-410 Antithrombotic Treatment in Cirrhosis....Pages 411-420 Front Matter....Pages 369-369 Session 6: Consensus Statements – Vascular Diseases of the Liver in Cirrhotic and Noncirrhotic Portal Hypertension....Pages 421-426