Portal Hypertension: Pathobiology, Evaluation, and Treatment (Clinical Gastroenterology)

Although the past several years have seen tremendous progress in both the understanding and clinical management of portal hypertension-a major complication of cirrhosis-many new therapies and pathogenic principles are now emerging that will lead to vastly improved therapeutic approaches in the years to come. In Portal Hypertension: Pathobiology, Evaluation, and Treatment, internationally renowned investigators and clinicians discuss the latest findings on key scientific topics and review the evaluation and management of portal hypertension in the clinic. Writing in an easy-to-read style, the authors review its pathobiology, the progress being made in its experimental understanding, the methodologies to assess it in humans, the treatment of its complications (esophageal varices, ascites, and hepatorenal syndrome), and its treatment in special circumstances (during pregnancy, in children, or when the portal vein is blocked). They also provide in-depth coverage of the pros and cons of the various therapeutic choices available to the clinician managing patients with complicated portal hypertension. State-of-the-art and readily accessible, Portal Hypertension: Pathobiology, Evaluation, and Treatment provides both an authoritative reference for all gastroenterologists and an indispensable resource for all physicians treating liver disease, particularly in a tertiary care setting. Portal hypertension: a history / Adrian Reuben and Roberto J. Groszmann Anatomy and vascular biology of the cells in the portal circulation / Massimo Pinzani and Francesco Vizzutti Cell and molecular mechanisms of increased intrahepatic resistance and hemodynamic correlates / Don C. Rockey Molecular mechanisms of systemic vasodilation and hyperdynamic circulatory state of cirrhosis / Richard Moreau and Didier Lebrec Mechanisms of sodium retention, ascites formation, and renal dysfunction in cirrhosis / Andrés Cardenas and Pere Ginès Hepatic hemodynamics in portal hypertension: compliance, hepatic arterial buffer Response, hepatorenal syndrome, and liver regeneration / W. Wayne Lautt and Zhi Ming Neovascularization, angiogenesis and vascular remodeling in portal hypertension / Manuel Morales-Ruiz and Wladimiro Jiménez Mechanisms of cardiopulmonary hemodynamics and dysfunction in portal hypertension / Michael B. Fallon Measurement of hepatic venous pressure gradient: methods, interpretation, and pitfalls / G. Pomier-Layrargues and P. Michel Huet Evaluation of portal hemodynamics using indicator dilution and noninvasive techniques / Juerg Reichen Endoscopic assessment of portal hypertension including variceal pressure measurement: methods, interpretation and pitfalls / Angel Escorsell and Jaime Bosch Clinical features and natural history of variceal hemorrhage: implications for surveillance and screening / Juan G. Abraldes and Jaime Bosch Management strategies for the prophylaxis and treatment of esophageal variceal rupture / Roberto de Franchis Pharmacologic therapy for the management of esophageal varices: biology and utility of available agents / Norman Grace and Richard S. Tilson Endoscopic treatment for bleeding esophageal varices / John P. Cello Surgical therapies for management: surgical shunts and liver transplantation / J. Michael Henderson Transjugular intrahepatic portasystemic stent-shunt: technical considerations and clinical utility in the management of variceal hemorrhage / Dhiraj Tripathi ... [et al.] Clinical features and management of gastric varices, portal hypertensive gastropathy, and ectopic varices / Charmaine A. Stewart and Patrick S. Kamath Ascites: clinical features, diagnosis and natural history / Sakib Karim Khalid and Guadalupe Garcia-Tsao Management of ascites / Florence Wong Spontaneous bacterial peritonitis and other infections in cirrhosis / Rosa Maria Morillas and Ramon Planas Diagnosis and management of hepatorenal syndrome / Kevin Moore Pregnancy and portal hypertension / Bimaljit Sandhu and Arun J. Sanyal Causes and management of portal hypertension in the pediatric population / Frederick C. Ryckman, Maria H. Alonso and Greg Tiao Noncirrhotic portal hypertension and portal vein thrombosis / Shiv Sarin and Manav Wadhavan Hepatic venous outflow obstruction: Budd-Chiari syndrome and veno-occlusive disease / Hugo E. Vargas and Thomas D. Boyer Pulmonary complications associated with portal hypertension / Karen L. Swanson and Michael J. Krowka Health status assessment and economic analyses in cirrhosis and portal hypertension / Jayant A. Talwalkar and W. Ray Kim Future treatments: anti-fibrotic agents, nitric oxide donors, and gene therapy in the treatment of portal hypertension / Meena B. Bansal and Scott L. Friedman. A.pdf......Page 1 front-matter.pdf......Page 2 Part I.pdf......Page 14 1.01 Portal Hypertension.pdf......Page 15 Part II.pdf......Page 24 2.02 Anatomy and Vascular Biology of the Cells in the Portal Circulation.pdf......Page 25 2.03 Cell and Molecular Mechanisms of Increased Intrahepatic Resistance and Hemodynamic Correlates.pdf......Page 46 2.04 Molecular Mechanisms of Systemic Vasodilation and Hyperdynamic Circulatory State of Cirrhosis.pdf......Page 60 2.05 Mechanisms of Sodium Retention, Ascites Formation, and Renal Dysfunction in Cirrhosis.pdf......Page 74 2.06 Hepatic Hemodynamics in Portal Hypertension.pdf......Page 94 2.07 Neovascularization, Angiogenesis, and Vascular Remodeling in Portal Hypertension.pdf......Page 107 2.08 Mechanisms of Cardiopulmonary Hemodynamics and Dysfunction in Portal Hypertension.pdf......Page 121 Part III.pdf......Page 134 3.09 Measurement of Hepatic Venous Pressure Gradient.pdf......Page 135 3.10 Evaluation of Portal Hemodynamics Using Indicator Dilution and Noninvasive Techniques.pdf......Page 151 3.11 Endoscopic Assessment of Portal Hypertension Including Variceal Pressure Measurements.pdf......Page 161 Part IV.pdf......Page 171 4.12 Clinical Features and Natural History of Variceal Hemorrhage.pdf......Page 172 4.13 Management Strategies for the Prophylaxis and Treatment of Esophageal Variceal Rupture.pdf......Page 187 4.14 Pharmacologic Therapy for Management of Esophageal Varices.pdf......Page 203 4.15 Endoscopic Treatment for Bleeding Esophageal Varices.pdf......Page 224 4.16 Surgical Therapies for Management.pdf......Page 238 4.17 Transjugular Intrahepatic Portosystemic Stent-Shunt.pdf......Page 249 4.18 Clinical Features and Management of Gastric Varices, Portal Hypertensive Gastropathy, and Ectopic Varices.pdf......Page 269 Part V.pdf......Page 289 5.19 Ascites.pdf......Page 290 5.20 Management of Ascites.pdf......Page 305 5.21 Spontaneous Bacterial Peritonitis and Other Infections in Cirrhosis.pdf......Page 322 5.22 Diagnosis and Management of the Hepatorenal Syndrome.pdf......Page 345 Part VI.pdf......Page 365 6.23 Pregnancy and Portal Hypertension.pdf......Page 366 6.24 Causes and Management of Portal Hypertension in the Pediatric Population.pdf......Page 383 6.25 Noncirrhotic Portal Hypertension and Portal Vein Thrombosis.pdf......Page 411 6.26 Hepatic Venous Outflow Obstruction.pdf......Page 433 6.27 Pulmonary Complications Associated with Portal Hypertension.pdf......Page 454 6.28 Health Status Assessment and Economic Analyses in Cirrhosis and Portal Hypertension.pdf......Page 468 6.29 Future Treatments.pdf......Page 484 back-matter.pdf......Page 503 "In Portal Hypertension: Pathobiology, Evaluation, and Treatment, internationally renowned investigators and clinicians discuss the latest findings on key scientific topics and review the evaluation and management of portal hypertension in the clinic. Writing in an easy-to-read style, the authors review its pathobiology, the progress being made in its experimental understanding, the methodologies to assess it in humans, the treatment of its complications (esophageal varices, ascites, and hepatorenal syndrome), and its treatment in special circumstances (during pregnancy, in children, or when the portal vein is blocked). They also provide in-depth coverage of the pros and cons of the various therapeutic choices available to the clinician managing patients with complicated portal hypertension." "State-of-the-art and readily accessible, Portal Hypertension: Pathobiology, Evaluation, and Treatment provides both an authoritative reference for all gastroenterologists and an indispensable resource for all physicians treating liver disease, particularly in a tertiary care setting."--BOOK JACKET A cutting-edge review of the latest findings on key scientific topics and the best strategies for evaluation and management of portal hypertension in the clinic. Writing in an easy-to-read style, the authors review its pathobiology, the progress being made in its experimental understanding, the methodologies to assess it in humans, the treatment of its complications (esophageal varices, ascites, and hepatorenal syndrome), and its treatment in special circumstances (during pregnancy, in children, or when the portal vein is blocked). They also provide in-depth coverage of the pros and cons of the various therapeutic choices available to the clinician managing patients with complicated portal hypertension.