Porphyrin Photosensitization (advances In Experimental Medicine And Biology) (volume 160)

This book contains contributions from participants at a Porphyrin Photosensitization Workshop held in Washington DC on 28-29 September, 1981. There had been several prior such gatherings during 1979 and 1980, but the 1981 meeting was the most extensive to date with almost 200 attending. These periodic meetings are designed to enable workers in the field to exchange information and learn of recent developments. Front Matter....Pages i-ix Introduction....Pages 1-2 Photoradiation Therapy — Clinical and Drug Advances....Pages 3-13 Intra-Abdominal Applications of Hematoporphyrin Photoradiation Therapy....Pages 15-21 Effectiveness of HPD and Radiation Therapy in Lung Cancer....Pages 23-39 Hematoporphyrin Derivative in the Diagnosis and Treatment of Lung Cancer....Pages 41-46 Laser Photoradiation Therapy of Recurrent Human Breast Cancer and Cancer of the Head and Neck....Pages 47-52 HPD Photoradiation Therapy for Cancer at Kingston and Hamilton....Pages 53-62 Light Dosimetry in Tissue: Application to Photoradiation Therapy....Pages 63-76 Thermal Distribution During Photoradiation Therapy....Pages 77-90 Photobiologic Considerations in Photoradiation Therapy....Pages 91-108 Preclinical Evaluation of Hematoporphyrin Derivative for the Treatment of Intraocular Tumors: A Preliminary Report....Pages 109-114 Porphyrin Localizing Phenomena....Pages 115-127 Aspects of the Cellular Uptake and Retention of Hematoporphyrin Derivative and Their Correlation with the Biological Response to PRT in Vitro....Pages 129-138 Cellular Uptake, Excretion and Localization of Hematoporphyrin Derivative (HPD)....Pages 139-150 Studies of HPD: Chemical Composition and in Vitro Photosensitization....Pages 151-164 Hematoporphyrin Derivative: Chemical Composition, Photochemical and Photosensitizing Properties....Pages 165-179 A Preliminary Comparison of the Photosensitizing Properties of Porphyrins in Aqueous Solution and Liposomal Systems....Pages 181-192 Factors Governing the Mechanism and Efficiency of Porphyrin-Sensitized Photooxidations in Homogeneous Solutions and Organized Media....Pages 193-212 Photodynamic Action of Protoporphyrin on Resealed Erythrocyte Membranes: Mechanisms of Release of Trapped Markers....Pages 213-225 Photodynamic Membrane Damage....Pages 227-240 HPD — A Study of Its Components and Their Properties....Pages 241-250 The Analysis of Hematoporphyrin Derivative....Pages 251-263 Potential use of Radiolabelled Porphyrins for Tumor Scanning....Pages 265-278 Excited State Interactions of Protoporphyrin IX and Related Porphyrins with Molecular Oxygen in Solutions and in Organized Assemblies....Pages 279-292 Back Matter....Pages 293-294