Polyomaviruses And Human Diseases (advances In Experimental Medicine And Biology)

Science never solves apr oblem without creating ten more Geor ge Bernard Shaw How prophetic the above words prove to be when applied to the advances of 20th century medicine. Prior to Banting and Best, chnicians were unaware of the ravages of diabetes, patients simply wasted away and died. Following the purifica­ tion of insulin, clinicians now had to deal with diabetic retinopathy, diabetic neph­ ropathy and all the other complications of long-term diabetes. A little over 50 years ago, the first successful human kidney transplant was performed in Boston. The first 30 years of the experience had successes when compared to the alternative but were a constant struggle to get even 50% of the grafts from deceased donors to survive more than a year. However, the science continued to advance knowledge of the immune response. With this came more and increasingly powerful tools for the clinician. Suddenly, success rates of 80-90% at one year were attainable. With this success came new problems, new complications and clinicians now had to worry about the long-term consequences of their therapy as patients were surviving with functional grafts for extended periods. A particular infectious complication evolved with the application of ever more powerful immunosuppressant drugs. Astute clinicians noted that occasionally cellular rejections seemed to get worse with steroids. Despite their best efforts and the use of powerful drugs, patients lost their grafts to overwhelming interstitial infiltrates not seen before. Polyomaviruses and human diseases / Nasimul Ahsan and Keerti V. Shah -- Discovery and epidemiology of the human polyomaviruses BK virus (BKV) and JC virus (JCV) / Wendy A. Knowles -- Phylogenomics and molecular evolution of polyomaviruses / Keith A. Crandall ... [et al.] -- Virus receptors and tropism / Aarthi Ashok and Walter J. Atwood -- Serological cross reactivity between polyomavirus capsids / Raphael P. Viscidi and Barbara Clayman -- Molecular genetics of the BK virus / Christopher L. Cubitt -- Serological diagnosis of human polyomavirus infection / Annika Lundstig and Joakim Dillner -- Human polyomavirus JC and BK persistent infection / Kristina Doerries -- Immunity and autoimmunity induced by polyomaviruses / Ole Petter Rekvig, Signy Bendiksen and Ugo Moens -- The pathobiology of polyomavirus virus infection in man / Parmjeet Randhawa, Abhay Vats and Ron Shapiro -- Polymoavirus-associated nephropathy in renal transplantation / Hans H. Hirsch ... [et al.] -- BK virus and immunosuppressive agents / Irfan Agha and Daniel C. Brennan -- BK virus infection after non-renal transplantation / Martha Pavlakis, Abdolreza Haririan and David K. Klassen -- Latent and productive polyomavirus infections of renal allografts / Volker Nickeleit, Harsharan K. Singh and Michael J. Mihatsch -- Urine cytology findings of polyomavirus infections / Harsharan K. Singh ... [et al.] -- Diagnosis and treatment of BK virus-associated transplant nephropathy / Abhay Vats, Parmjeet S. Randhawa and Ron Shapiro -- Pharmacotherapeutic options for the management of human polyomaviruses / Julie Roskopf ... [et al.] -- Leflunomide in solid organ transplantation and polyoma virus infection / Michelle A. Josephson ... [et al.] -- JC virus can infect human immune and nervous system progenitor cells / Jean Hou, Pankaj Seth and Eugene O. Major -- The polyomavirus, JCV, and its involvement in human disease / Kamel Khalili, Jennifer Gordon, and Martyn K. White -- Transforming activities of JC virus early proteins / Richard J. Frisque, Catherine Hofstetter and Shiva K. Tyagarajan -- Polyomavirus in human cancer development / Winston Lee and Erik Langhoff -- BK virus, JC virus, and simian virus 40 infection in humans, and association with human tumors / Giuseppe Barbanti-Brodano ... [et al.] -- Epidemiologic studies of polyomaviruses and cancer / Dana E.M. Rollison Polyomaviruses and Human Diseases....Pages 1-18 Discovery and Epidemiology of the Human Polyomaviruses BK Virus (BKV) and JC Virus (JCV)....Pages 19-45 Phylogenomics and Molecular Evolution of Polyomaviruses....Pages 46-59 Virus Receptors and Tropism....Pages 60-72 Serological Cross Reactivity between Polyomavirus Capsids....Pages 73-84 Molecular Genetics of the BK Virus....Pages 85-95 Serological Diagnosis of Human Polyomavirus Infection....Pages 96-101 Human Polyomavirus JC and BK Persistent Infection....Pages 102-116 Immunity and Autoimmunity Induced by Polyomaviruses....Pages 117-147 The Pathobiology of Polyomavirus Infection in Man....Pages 148-159 Polyomavirus-Associated Nephropathy in Renal Transplantation....Pages 160-173 BK Virus and Immunosuppressive Agents....Pages 174-184 BK Virus Infection after Non-Renal Transplantation....Pages 185-189 Latent and Productive Polyomavirus Infections of Renal Allografts....Pages 190-200 Urine Cytology Findings of Polyomavirus Infections....Pages 201-212 Diagnosis and Treatment of BK Virus-Associated Transplant Nephropathy....Pages 213-227 Pharmacotherapeutic Options for the Management of Human Polyomaviruses....Pages 228-254 Leflunomide in Solid Organ Transplantation and Polyoma Virus Infection....Pages 255-265 JC Virus Can Infect Human Immune and Nervous System Progenitor Cells....Pages 266-273 The Polyomavirus, JCV, and Its Involvement in Human Disease....Pages 274-287 Transforming Activities of JC Virus Early Proteins....Pages 288-309 Polyomavirus in Human Cancer Development....Pages 310-318 BK Virus, JC Virus and Simian Virus 40 Infection in Humans, and Association with Human Tumors....Pages 319-341 Epidemiologic Studies of Polyomaviruses and Cancer....Pages 342-356 Explains the means of diagnosis and treatment of polyomavirus, and outlines the history, pathology, symptoms, and treatment of diseases induced by human polyomavirus. This book discusses the virus and explores the information on polyomavirus, transplant related pathobiology, histopathology, diagnosis, management, and pharmacotherapy