Platelets, Haemostasis and Inflammation (Cardiac and Vascular Biology, 5)

"The book depicts the various roles of platelets in a variety of cardio-metabolic diseases. Traditional and non-traditional platelet functions are described in detail in atherosclerosis, metabolic syndrome, diabetes, myocardial infarction, and other vascular pathologies. Particular focus is put on platelets as a link between haemostasis and inflammation contributing to both. Last but not least the books links the most recent advances in basic sciences with promising novel therapeutic applications and first results of clinical trials. The book is written for biomedical scientists in the sub disciplines vascular biology, biochemistry and immunology; and it as well will be of interest and value for academic physicians like cardiologists, hematologists, general internists and vascular surgeons"--Back cover Front Matter ....Pages i-viii Cardiac Imaging of Platelets and Inflammation (Constantin von zur Mühlen, Robin P. Choudhury)....Pages 1-13 In the Heat of the Artery: Inflammation as Trigger and Target of Atherosclerosis (Peter Stachon, Andreas Zirlik)....Pages 15-27 Vaccination to Prevent Cardiovascular Disease (Dennis Wolf, Teresa Gerhardt, Klaus Ley)....Pages 29-52 Platelets as Regulators of Thrombosis and Inflammation (Daniel Duerschmied, Steffen Massberg)....Pages 53-80 Diversity of Inflammatory Cells in Vascular Degenerative Disease (Ingo Hilgendorf, Filip K. Swirski)....Pages 81-97 Platelet Inhibition as a Therapeutic Approach in Intravascular Intervention (Ingo Ahrens, Hector Bueno)....Pages 99-109 Diabetes, Thrombosis, and Cardiovascular Risks (Katharina Schuett, Nikolaus Marx)....Pages 111-124 Microparticles: Surrogate Markers and Promoters of Cardiovascular Diseases (Martin Moser, Philipp Diehl)....Pages 125-135 Mechanisms of Platelet Activation in Diabetes Mellitus (Florian Willecke, Prabhakara R. Nagareddy, Andrew J. Murphy)....Pages 137-152 Platelet Chemokines in New Modes of Action (Madhumita Chatterjee, Meinrad Gawaz)....Pages 153-180 PI3K-Dependent Platelet Signaling in Vascular Inflammation and Atherothrombosis (Oliver Borst, Florian Lang, Patrick Münzer)....Pages 181-198 Linking Pathologies: Cyclophilins in Inflammation and Thrombosis (David Heinzmann, Andreas E. May, Peter Seizer)....Pages 199-208 Platelets and Innate Immunity in Atherosclerosis (Johannes Patzelt, Harald F. Langer)....Pages 209-221 Platelets and HMGB1 in Sterile and Non-sterile Inflammation (Sebastian Vogel, Meinrad Gawaz)....Pages 223-230 cGMP Signaling in Platelets (Lai Wen, Susanne Feil, Robert Feil)....Pages 231-252 Platelets and Stroke (Felix Fluri, Bernhard Nieswandt, Guido Stoll, Christoph Kleinschnitz)....Pages 253-274 Platelets and Polymorphisms (Tobias Geisler, Elke Schaeffeler, Matthias Schwab)....Pages 275-292