Plasma Protein Metabolism. Regulation of Synthesis, Distribution , and Degradation

Plasma Protein Metabolism: Regulation of Synthesis, Distribution, and Degradation covers the concepts concerning the physiological and pathophysiological factors regulating the distribution, degradation, and synthesis of plasma proteins. This book is organized into nine parts encompassing 32 chapters. The first parts present the assumptions and methodology involved in the various in vivo and in vitro techniques that provide insights to protein metabolism. The next parts describe the techniques of protein isolation, characterization, labeling, and mathematical analysis of the data, as well as the methods for directly quantitating protein synthetic rates in nonsteady state conditions. Other parts are devoted to the factors involved in regulating the serum levels of albumin, acute phase reactants, immunoglobulins, clotting factors, complement and hormone-binding proteins. The controlling factors include such general and specific physiological regulators of protein synthesis and catabolism as levels of specific serum proteins, hormonal regulators, variations of temperature and oncotic pressure, antigenic stimulation, and nutritional factors. The remaining parts analyze the pathophysiological factors including disorders of protein synthesis, distribution, exogenous catabolism, and external loss and stress that produce abnormal levels of serum proteins. This book is intended primarily intended to protein chemists and researchers. Content: CONTRIBUTORS , Page ii Front Matter , Page iii Copyright , Page iv LIST OF CONTRIBUTORS , Pages xvii-xxi PREFACE , Pages xxiii-xxiv 1 - MEASUREMENTS REQUIRED TO DEFINE BEHAVIOR OF A PLASMA PROTEIN IN VIVO: THE NEED FOR MEASURING PROTEIN SYNTHETIC RATE WITH A CRITICISM OF AVAILABLE METHODS , Pages 3-9 , E.B. Reeve 2 - AN APPROACH TO THE INVESTIGATION OF THE DYNAMIC STRUCTURE OF A COMPLEX BIOLOGICAL SYSTEM INCORPORATING STATE VARIABLE DIAGRAM ANALYSIS , Pages 11-23 , E.A. Jones, E. Carson, V.M. Rosenoer 3 - MODELS FOR PROTEIN SYNTHESIS STUDIES , Pages 25-49 , R. Bianchi, L. Donato, P. Mancini, G. Mariani, A. Pilo, F. Vitek 4 - SYNTHESIS AND DEGRADATION OF PLASMA PROTEINS , Pages 51-61 , A.S. McFarlane 5 - TECHNIQUES FOR PROTEIN SEPARATION , Pages 63-86 , Tristram Freeman 6 - REGULATION OF INTERSTITIAL ALBUMIN , Pages 89-109 , E.B. Reeve, A.Y. Chen 7 - THE EXTRAVASCULAR TRANSPORT OF ALBUMIN , Pages 111-127 , Victor M. Rosenoer, Marcus A. Rothschild 8 - STUDIES ON THE EXTRAVASCULAR ALBUMIN OF RATS , Pages 129-154 , J. Katz, A.L. Sellers, G. Bonorris, S. Golden 9 - FACTORS IN REGULATION OF LIVER PROTEIN SYNTHESIS , Pages 157-167 , Hamish N. Munro 10 - IDENTIFICATION OF PROTEINS MADE ON MICROSOMES AND FREE RIBOSOMES OF RAT LIVER , Pages 169-184 , Curtis A. Williams, M. Clelia Ganoza 11 - SERUM PROTEIN SYNTHESIS IN RATS FORCE-FED A THREONINE-DEVOID DIET , Pages 185-196 , Jerry Lynn, Herschel Sidransky 12 - ALBUMIN METABOLISM , Pages 199-206 , Marcus A. Rothschild, Murray Oratz, Sidney S. Schreiber 13 - NUTRITIONAL, HORMONAL, AND TEMPORAL FACTORS REGULATING NET PLASMA PROTEIN BIOSYNTHESIS IN THE ISOLATED PERFUSED RAT LIVER: Effects of Feeding or Fasting Liver Donors and of Supplementation with Amino Acids, Insulin, Cortisol, and Growth Hormone , Pages 207-222 , Leon L. Miller, David W. John 14 - ONCOTIC PRESSURE AND ALBUMIN SYNTHESIS , Pages 223-238 , Murray Oratz 15 - CONTROL OF ALBUMIN DEGRADATION IN VIVO AND IN THE PERFUSED LIVER , Pages 239-255 , R. Hoffenberg 16 - GENETIC REGULATION OF IMMUNOGLOBULIN LEVELS IN MAN , Pages 259-268 , Edward C. Franklin 17 - PHYSIOLOGICAL FACTORS CONTROLLING IMMUNOGLOBULIN METABOLISM , Pages 269-286 , T.A. Waldmann, R.M. Blaese, W. Strober 18 - ABNORMALITIES OF IMMUNOGLOBULIN METABOLISM , Pages 287-305 , Warren Strober, R. Michael Blaese, Thomas A. Waldmann 19 - THE SUBMOLECULAR SITE RELATED TO THE RATE OF CATABOLISM OF IgG IMMUNOGLOBULINS , Pages 307-319 , Hans L. Spiegelberg 20 - THE INFLUENCE OF GASTROINTESTINAL TRACT ON γ-GLOBULIN METABOLISM , Pages 321-335 , S. Jarnum, G. Bendixen, K.B. Jensen, J. Soltoft, B. Weeke, H. Westergaard 21 - PROTEIN-LOSING ENTEROPATHIES OF LYMPHATIC ORIGIN , Pages 337-347 , P. Vesin, Cl. Marche 22 - THE EFFECTS OF TRAUMA AND PARTIAL HEPATECTOMY ON THE RATES OF SYNTHESIS OF PLASMA PROTEINS BY THE LIVER , Pages 351-368 , A.H. Gordon 23 - REGULATION OF PLASMA α 2 - (ACUTE PHASE) GLOBULIN SYNTHESIS IN RAT LIVER , Pages 369-382 , E.J. Sarcione 24 - ANALYSIS OF “ACUTE PHASE” PROTEIN SYNTHESIS IN THE MOUSE BY IMMUNOELECTROPHORESIS , Pages 383-392 , Curtis A. Williams 25 - REGULATION AND METABOLISM OF THE THIRD COMPONENT OF COMPLEMENT (C3) , Pages 393-413 , Chester A. Alper 26 - REGULATION OF PROTEIN METABOLISM IN BURNS , Pages 415-425 , Gunnar Birke 27 - METABOLISM OF α 2 - MACROGLOBULIN ; Regulation and Distribution , Pages 427-436 , Renee Norberg, G. Birke, Eva Hedfors, L.-O. Plantin 28 - REGULATION OF THE METABOLISM OF PROTEINS INVOLVED IN BLOOD COAGULATION , Pages 439-441 , Erwin Regoeczi 29 - EFFECTS OF TYPHOID ENDOTOXIN ON FIBRINOGEN AND PROTHROMBIN METABOLISM IN CALVES , Pages 443-458 , Y. Takeda 30 - ABNORMAL FIBRINOGEN METABOLISM , Pages 459-479 , Erwin Regoeczi 31 - THE METABOLISM OF PLASMA LIPOPROTEINS , Pages 483-503 , Terry Langer, Warren Strober, Robert I. Levy 32 - REGULATION OF HORMONES BY BINDING PROTEINS: With Special Reference to the Transport of Thyroxine in the Circulation , Pages 507-533 , Kenneth Sterling AUTHOR INDEX , Pages 535-553 SUBJECT INDEX , Pages 555-560