Plant Phenolics and Human Health: Biochemistry, Nutrition and Pharmacology (The Wiley-IUBMB Series on Biochemistry and Molecular Biology)

A collection of current knowledge of phytochemicals and health Interest in phenolic phytochemicals has increased as scientific studies indicate these compounds exhibit potential health benefits. With contributions from world leaders in this research area, Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology offers an essential survey of the current knowledge on the capacity of specific micronutrients present in ordinary diets to fight disease. The coverage in this resource: Explains the presence and biochemical properties of phenolics present in fruits and vegetables, as well as in foods derived from their plant sources Provides biochemical explanations on how certain plant phenolics fight cardiovascular and neurodegenerative diseases, cancer, and other widespread pathologies Focuses on certain phenolics, e.g., flavonoids, stilbenes, and curcuminoids, and provides insights on the biochemical bases used to define their significance in the diet as well as their recommended consumption requirements and toxicity Appropriate for graduate and upper-level undergraduate courses in human and animal nutrition, basic nutritional biology, physiology, pharmacology, and other health-related disciplines, Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology serves as both an invaluable supplementary classroom text and a self-teaching guide for professionals interested in defining the association between diet and health from classical, alternative, and complementary biomedical perspectives. Dietary flavonoids and phenolic compounds / Indu B. Jaganath and Alan Crozier Bioavailability of flavonoids and phenolic acids / Laure Poquet, Michael N. Clifford, and Gary Williamson Biochemical actions of plant phenolics compounds : thermodynamic and kinetic aspects / Cesar G. Fraga, Gulcin Sagdicoglu Celep, and Monica Galleano Flavonoids-membrane interactions : consequences for biological actions / Sandra V. Verstraeten, Cesar G. Fraga, and Patricia I. Oteiza The biochemistry behind the potential cardiovascular protection by dietary flavonoids / Wai Mun Loke, Jonathan M. Hodgson, and Kevin D. Croft Dietary flavanols : biochemical basis of short-term and longer-term vascular responses / Tankred ... [et al.] Green tea catechins : anticancer effects and molecular targets / Naghma Khan and Hasan Mukhtar Flavonols : metabolism, bioavailability, and health impacts / Junji Terao Flavonols : biochemistry behind cardiovascular effects / Francisco Pérez-Vizcaíno and Juan Duarte Metabolism, bioavailability, and analysis of dietary isoflavones / Adrian A. Franke ... [et al.] Phytoestrogens up-regulate antioxidant genes / Consuelo Borrás and Jose Viña Dietary isoflavones : cardiovascular actions and activation of cellular signalling pathways / Richard C.M. Siow and Giovanni E. Mann Bioavailability and metabolism of resveratrol / Christina Andres-Lacueva ... [et al.] Resveratrol : biochemistry and functions / Samarjit Das, Hannah R. Vasanthi, and Dipak K. Das Resveratrol : the biochemistry behind its anticancer effects / Joydeb K. Kundu and Young-Joon Surh Curcumin : the biochemistry behind its anticancer effects / Preetha Anand, Ajaikumar B. Kunnumakkara, and Bharat B. Aggarwal Plant phenolic compounds : modulation of cytoprotective enzymes and Nrf2/ARE signaling / Siwang Yu ... [et al.] Phenolics in aging and neurodegenerative disorders / Vittorio Calabrese ... [et al.] Natural phenolics and metal metabolism in neurodegenerative diseases / Baolu Zhao Epidemiology behind fruit and vegetable consumption and cancer risk with focus on flavonoids / Marta Rossi ... [et al.] Phenylpropanoid metabolism in plants : biochemistry, functional biology, and metabolic engineering / Alberto B. Landolino and Douglas R. Cook. PLANT PHENOLICS AND HUMAN HEALTH......Page 4 CONTENTS......Page 8 PREFACE......Page 10 CONTRIBUTORS......Page 12 1 Dietary Flavonoids and Phenolic Compounds......Page 18 2 Bioavailability of Flavanols and Phenolic Acids......Page 68 3 Biochemical Actions of Plant Phenolics Compounds: Thermodynamic and Kinetic Aspects......Page 108 4 Flavonoids–Membrane Interactions: Consequences for Biological Actions......Page 124 5 The Biochemistry Behind the Potential Cardiovascular Protection by Dietary Flavonoids......Page 154 6 Dietary Flavanols: Biochemical Basis of Short-Term and Longer-Term Vascular Responses......Page 176 7 Green Tea Catechins: Anticancer Effects and Molecular Targets......Page 182 8 Flavonols: Metabolism, Bioavailability, and Health Impacts......Page 202 9 Flavonols: Biochemistry Behind Cardiovascular Effects......Page 214 10 Metabolism, Bioavailability, and Analysis of Dietary Isoflavones......Page 232 11 Phytoestrogens Up-regulate Antioxidant Genes......Page 256 12 Dietary Isoflavones: Cardiovascular Actions and Activation of Cellular Signalling Pathways......Page 266 13 Bioavailability and Metabolism of Resveratrol......Page 282 14 Resveratrol: Biochemistry and Functions......Page 316 15 Resveratrol: The Biochemistry Behind its Anticancer Effects......Page 348 16 Curcumin: The Biochemistry Behind Its Anticancer Effects......Page 378 17 Plant Phenolic Compounds: Modulation of Cytoprotective Enzymes and Nrf2/ARE Signaling......Page 418 18 Phenolics in Aging and Neurodegenerative Disorders......Page 444 19 Natural Phenolics and Metal Metabolism in Neurodegenerative Diseases......Page 470 20 Epidemiology behind Fruit and Vegetable Consumption and Cancer Risk with Focus on Flavonoids......Page 488 21 Phenylpropanoid Metabolism in Plants: Biochemistry, Functional Biology, and Metabolic Engineering......Page 506 INDEX......Page 582 "Interest in phenolic phytochemicals has increased as scientific studies indicate these compounds exhibit potential health benefits. With contributions from world leaders in this research area, Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology offers an essential survey of the current knowledge on the capacity of specific micronutrients present in ordinary diets to fight disease." "Appropriate for graduate and upper-level undergraduate courses in human and animal nutrition, basic nutritional biology, physiology, pharmacology, and other health-related disciplines, Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology serves as both an invaluable, supplementary classroom text and a self-teaching guide for professionals interested in defining the association between diet and health from classical, alternative, and complementary biomedical perspectives."--Jacket Health benefits and mode of action of flavonoids and phenolic compounds Flavonoids : structure and their dietary occurrence Flavonols Flavones Flavan-3-ols Flavanones and chalcones Anthocyanidins/anthocyanins Isoflavones Non-flavonoid phenolic compounds : structure and their dietary occurrence Phenolic acids Hydroxycinammates Stilbenes Overview of flavonoid and phenolic biosynthetic pathways Optimization of the flavonoid and phenolic profiles in crop plants Agronomical and physiological modification Genetic manipulation : conventional breeding and genetic engineering Future trends and prospects.