Phytopharmaceuticals in Cancer Chemoprevention (Modern Nutrition Science Book 2)

This book focuses on the role of natural supplements in cancer prevention and therapy. The first section covers cancer epidemiology, cancer statistics and current therapies and potential toxicities involved with existing cancer drugs. The second section discusses the pathophysiology of cancer including mechanistic and molecular aspects of cancer biology, etiology of breast cancer, lung cancer, prostate cancer, tobacco and cancer, gastrointestinal tract cancers and various risk factors related to obesity, exercise and aging. The third section covers phytopharmaceuticals and focuses on cancer health risk factors and the protective abilities of the various natural products. Contributors......Page 14 Table of Contents......Page 22 1 Epidemiology of Cancer: an Overview......Page 26 2 Role of DNA Methylation in Cancer and Chemotherapy......Page 43 3 Metals, Metalloids, and Cancer......Page 58 4 Molecular Mechanisms of Asbestos- and Silica-Induced Lung Cancer......Page 72 5 Involvement of Receptor Tyrosine Kinases in Lung Cancer: Clinical Importance......Page 98 6 Free Radicals, Environmental Radiation, and Cancer......Page 121 7 Smokeless Tobacco, Oxidative Stress, and Oral Cancer......Page 132 8 The Regulatory Roles of Estrogen in Carcinogenesis: an Overview......Page 152 9 Nonsteroidal Anti-Inflammatory Drugs (NSAID) and Colorectal Cancer......Page 179 10 Current Perspectives in Gastric Adenocarcinoma......Page 202 11 Adenocarcinoma of the Esophagus......Page 212 12 Helicobacter pylori and Gastric Cancer......Page 227 13 Free Radicals, Oxidative Stress, and Cancer......Page 237 14 Biotransformation and Mechanism of Action of Xenobiotics: What Lessons from the Past 40 Years?......Page 256 15 Obesity and Cancer......Page 266 16 Hemangioendothelioma as a Model to Study the Antiangiogenic Effects of Dietary Chemopreventive Agents In Vivo......Page 275 17 Modulation of Late Adverse Effects of Curative Radiation Therapy for Cancer......Page 286 18 Development of Selected Phytochemicals for Cancer Chemoprevention......Page 301 19 Phytochemicals as Potential Cancer Chemopreventive Agents......Page 311 20 History of Natural Supplements in Cancer Therapy and Prevention......Page 323 21 Vitamin C, Vitamin E, and β-Carotene in Cancer Chemoprevention......Page 352 22 Roles of Polyphenols, Flavonoids, and Oligomeric Proanthocyanidins in Cancer Chemoprevention......Page 399 23 Curcumin Derived from Turmeric (Curcuma longa): a Spice for All Seasons......Page 445 24 Tea in Chemoprevention of Cancer......Page 492 25 Phytoestrogens in Cancer Prevention: Characterization and Beneficial Effects of Kurarinone, a New Flavanone and a Major Phytoestrogen Constituent of Sophora flavescens Ait......Page 538 26 Resveratrol in the Chemoprevention and Chemotherapy of Breast Cancer......Page 566 27 Berries and Fruits in Cancer Chemoprevention*......Page 584 28 Palm Tocotrienols and Cancer......Page 601 29 Pycnogenol® in Cancer Chemoprevention......Page 614 30 Overview of the Use of Maitake Mushroom and Fraction D in Cancer......Page 636 31 Taxol in Cancer Treatment and Chemoprevention......Page 647 32 Lycopene and Cancer......Page 654 33 NADH in Cancer Prevention and Therapy......Page 674 34 Astaxanthin and Cancer Chemoprevention......Page 690 35 Chemopreventive Effects of Selected Spice Ingredients......Page 713 36 Coenzyme Q10 and Neoplasia: Overview of Experimental and Clinical Evidence*......Page 742 37 Probiotics in the Prevention of Cancer......Page 772 Commentary 1 Do Dietary Antioxidants Really Help Prevent or Treat Cancer?......Page 790 Commentary 2 Who Gets Cancer? Do Healthy Foods, Healthy Living, and Natural Antioxidants Really Help?......Page 795 Concluding Remarks......Page 798 Index......Page 799

During the past decade, a significant amount of research has been conducted on phytopharmaceuticals. Today, a growing body of evidence demonstrates the efficacy of a wide variety of natural products and affirms their potential in the treatment of cancer.

Phytopharmaceuticals in Cancer Chemoprevention focuses on the role of natural supplements in cancer prevention and therapy. The first section covers cancer epidemiology, as well as cancer statistics, current therapies, and potential toxicities involved with existing cancer drugs. The second section begins by discussing the pathophysiology of cancer including mechanistic and molecular aspects of cancer biology, and then explains the etiology of breast cancer, lung cancer, prostate cancer, tobacco and cancer, and gastrointestinal tract cancers, and concludes with the various risk factors related to obesity, exercise and aging. The third section covers phytopharmaceuticals and focuses on cancer health risk factors and the protective abilities of various natural products. The final section features commentary on cancer susceptibility and the value of natural remedies for healthy living.

With contributions from a diverse panel of renowned scientists and cancer biologists, this book covers a broad spectrum of phytopharmaceuticals in relation to their prospective roles in the future of cancer prevention and treatment. It is a valuable resource for nutrition scientists, oncologists, and dietitians in their efforts to conquer the challenge of cancer.

When I was asked to serve as the series editor of Modern Nutrition Science, I jumped atthe opportunity. I have worked in the field of nutrition for 30 years both as a researcherand as a dietitian. This role gave me the opportunity to select expert colleagues, many ofwhom are key thought leaders in the field, to be volume editors for the individual booksin the series. I am happy to report that in each case, my first choice for book editoraccepted the job "With contributions from a diverse panel of renowned scientists and cancer biologists, Phytopharmaceuticals in Cancer Chemoprevention covers a broad spectrum of phytopharmaceuticals in relation to their prospective roles in the future of cancer prevention and treatment. The book focuses on the role of natural supplements in cancer prevention and therapy."--BOOK JACKET