Physiology of the gastrointestinal tract. Volume 1 and 2 / editor-in-chief, Hamid M. Said ; associate editors, Fayez K. Ghishan [and three others

Physiology of the Gastrointestinal Tract, Sixth Edition , a Two-Volume set, covers the study of the mechanical, physical and biochemical functions of the GI Tract by linking clinical disease and disorder, thus bridging the gap between clinical and laboratory medicine while also covering breakthroughs in gastroenterology, such as the brain-gut axis and microbiome. Additionally, information is provided at the organism level, including animal models of gastrointestinal disorders and therapeutic possibilities. The book covers a wide range of conditions, from food allergies, constipation, chronic liver disease and IBS, also exploring emerging techniques to diagnose and normalize functions of the GI tract. As a highly referenced book, this is a useful resource for gastroenterologists, physiologists, internists, professional researchers and instructors teaching courses for clinical and research students. Discusses the multiple processes governing gastrointestinal function Presents new information on the brain-gut axis and microbiome Edited by preeminent scientists in the field Includes coverage of issues, such as food allergies, constipation, chronic liver disease, IBS, Crohn's disease, and more Front Cover Physiology of the Gastrointestinal Tract Copyright Contents Contributors Preface Volume 1 Section I: Basic Cell Physiology, Genetics, and Growth of the GI Tract Chapter 1: Transcription and Epigenetic Regulation 1.1. Overview of Gene Organization 1.1.1 Nucleic Acids 1.1.2 Nucleic Acid Polymers: DNA, RNA 1.1.3 Gene Composition 1.1.4 RNA Species 1.1.5 Linking Gene Structure to Function 1.2. Epigenetic Influences 1.2.1 DNA Methylation 1.2.2 Histone Modifications 1.2.2.1 Histone Acetylation 1.2.2.2 Histone Methylation 1.2.2.2.1 Histone Methylation at Lysines. 1.2.2.2.2 Histone Methylation at Arginines1.2.2.3 Histone Phosphorylation 1.2.3 Chromatin-Binding Proteins 1.2.4 Epigenetics and Development 1.2.5 Epigenetics and Cancer 1.3. Anatomy of a Gene Promoter 1.3.1 DNA Elements 1.4. Methodology 1.4.1 Structural Methods 1.4.1.1 Chromatin Immunoprecipitation Assays 1.4.1.2 Microarray Technology 1.4.1.3 Whole Genome Sequencing 1.4.1.4 Proteomics 1.4.1.5 Bioinformatics and Computational Biology 1.5. Posttranscriptional Processing 1.5.1 Polyadenylation 1.5.2 RNA Splicing 1.5.2.1 The Spliceosome 1.5.2.2 Alternative Splicing. 1.5.2.3 Regulated Posttranscriptional Mechanismsâ#x80 #x94 mRNA Stability1.5.2.4 Regulated Posttranscriptional Mechanismsâ#x80 #x94 mRNAs 1.6. Transport Across the Nuclear Membrane 1.7. Concluding Remarks Acknowledgment References Chapter 2: Gastrointestinal Hormones 2.1. Introduction 2.1.1 Production and Processing of Peptides by Enteroendocrine Cells 2.1.2 How Do EECs Respond to Nutrition-Related Stimuli? 2.1.3 Pathophysiology Affecting Multiple Enteroendocrine Cell Subtypes 2.1.4 Details of Specific Gut Hormones With Known Biological and Pathophysiological Roles 2.2. Gastrin 2.2.1 Synthesis. 2.2.2 Secretion2.2.3 Function 2.2.4 Clinical Aspects 2.3. SST 2.3.1 Synthesis 2.3.2 Secretion 2.3.3 Receptors 2.3.4 Function 2.3.4.1 Stomach 2.3.4.2 Gastrointestinal Motility 2.3.4.3 Intestinal and Pancreatic Endocrine and Exocrine Secretion 2.3.4.4 Splanchnic Circulation 2.3.5 Clinical Aspects 2.4. Ghrelin 2.4.1 Synthesis 2.4.2 Secretion 2.4.3 Function 2.4.4 Clinical Aspects 2.5. CCK 2.5.1 Synthesis 2.5.2 Secretion 2.5.3 Function 2.5.4 Clinical Aspects 2.6. Secretin 2.6.1 Synthesis 2.6.2 Secretion 2.6.3 Function 2.6.4 Clinical Aspects 2.7. Motilin 2.7.1 Secretion. 2.7.2 Function2.7.3 Clinical Aspects 2.8. Neurotensin 2.8.1 Synthesis 2.8.2 Secretion 2.8.3 Function 2.8.4 Clinical Aspects 2.9. GIP 2.9.1 Synthesis 2.9.2 Secretion 2.9.3 Function 2.9.4 Clinical Aspects 2.10. Proglucagon-Derived Peptides 2.10.1 Synthesis 2.10.2 Secretion 2.10.3 GLP-1 2.10.4 GLP-2 2.10.5 Oxyntomodulin 2.10.6 Glicentin 2.11. PYY 2.11.1 Synthesis 2.11.2 Secretion 2.11.3 Function 2.11.4 Clinical Aspects 2.12. Insulin-Like Peptide 5 2.12.1 Synthesis 2.12.2 Secretion 2.12.3 Function 2.12.4 Clinical Aspects 2.13. Serotonin and Histamine. "Physiology of the Gastrointestinal Tract, Sixth Edition, a Two-Volume set, covers the study of the mechanical, physical and biochemical functions of the GI Tract by linking clinical disease and disorder, thus bridging the gap between clinical and laboratory medicine while also covering breakthroughs in gastroenterology, such as the brain-gut axis and microbiome. Additionally, information is provided at the organism level, including animal models of gastrointestinal disorders and therapeutic possibilities. The book covers a wide range of conditions, from food allergies, constipation, chronic liver disease and IBS, also exploring emerging techniques to diagnose and normalize functions of the GI tract. As a highly referenced book, this is a useful resource for gastroenterologists, physiologists, internists, professional researchers and instructors teaching courses for clinical and research students. Discusses the multiple processes governing gastrointestinal function Presents new information on the brain-gut axis and microbiome Edited by preeminent scientists in the field Includes coverage of issues, such as food allergies, constipation, chronic liver disease, IBS, Crohn's disease, and more"--Publisher's description Physiology of the Gastrointestinal Tract, Sixth Edition, a Two-Volume set, covers the study of the mechanical, physical and biochemical functions of the GI Tract by linking clinical disease and disorder, thus bridging the gap between clinical and laboratory medicine while also covering breakthroughs in gastroenterology, such as the brain-gut axis and microbiome. Additionally, information is provided at the organism level, including animal models of gastrointestinal disorders and therapeutic possibilities. The book covers a wide range of conditions, from food allergies, constipation, chronic liver disease and IBS, also exploring emerging techniques to diagnose and normalize functions of the GI tract. As a highly referenced book, this is a useful resource for gastroenterologists, physiologists, internists, professional researchers and instructors teaching courses for clinical and research students. Discusses the multiple processes governing gastrointestinal function Presents new information on the brain-gut axis and microbiome Edited by preeminent scientists in the field Includes coverage of issues, such as food allergies, constipation, chronic liver disease, IBS, Crohn's disease, and more. --Publisher Physiology of the Gastrointestinal Tract, Sixth Edition, (2018) 1-1752. 978-0-12-809954-4