Phosphate metabolism : [proceedings of the second international workshop on Phosphate held in Heidelberg, Germany, June 28-30, 1976

We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro­ priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac­ tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or­ ganizing Committee, therefore, decided to continue with the tradi­ tion to hold additional Workshops annually or every other year. Front Matter....Pages i-xiii Front Matter....Pages 1-1 Renal Handling of Phosphate: Update....Pages 3-14 Renal Handling of Calcium: Overview....Pages 15-27 Renal Tubular Effects of Vitamin D and Its Metabolites....Pages 29-40 Phylogeny of Renal Phosphate Transport in the Vertebrates....Pages 41-53 Transepithelial Transport of Phosphate Anion in Kidney. Potential Mechanisms for Hypophosphatemia....Pages 55-70 Renal Adenylate Cyclase, Calcitonin Receptors and Phosphate Excretion in Rats Immunized Against Tubular Basement Membranes....Pages 71-73 Renal Tubular Handling of 3′,5′ — cAMP in Normal and Parathyroidectomized Rats....Pages 75-76 Effects of Glucose on Intestinal and Renal Handling of Calcium....Pages 77-84 Renal Actions of 25-Hydroxyvitamin D 3 ....Pages 85-93 Hypercalciuria after Diphenylhydantoin....Pages 95-100 Renal Phosphate Transport in the Phosphate-Depleted Dogs....Pages 101-103 Dissociated Reabsorption of Phosphate and Bicarbonate in the Post-Obstructed Dog Kidney....Pages 105-113 Parathyroid Hormone-Induced Inhibition of Bicarbonate-Dependent Fluid Absorption in the Proximal Renal Tubule of the Rabbit....Pages 115-120 Renal Handling of Sodium, Water and Divalent Ions in Patients with Primary Biliary Cirrhosis....Pages 121-129 Minor Influence of Parathyroid Hormone on Fractional Tubular Reabsorption of Phosphate in Chronic Renal Failure....Pages 131-139 The Maximal Tubular Reabsorption of Phosphate in Relation to Serum Parathyroid Hormone....Pages 141-148 The Postproximal Site of Phosphate Reabsorption in Presence and Absence of Parathyroid Hormone....Pages 149-151 Saturation Kinetics of Phosphate Reabsorption in Rats....Pages 153-155 Hypocalciuric Effect of Lithium in Man....Pages 157-172 The Renal Handling of Phosphate by Renal Transplant Patients: Correlation with Serum Parathyroid Hormone (S PTH ), Cyclic 3′,5′-Adenosine Monophosphate (cAMP) Urinary Excretion, and Allograft Function....Pages 173-181 Front Matter....Pages 1-1 Independence of Phosphate Homeostasis From Parathyroid Function in the Phosphate-Depleted Rat....Pages 183-192 Front Matter....Pages 193-193 Regulation of Vitamin D Metabolism in the Kidney....Pages 195-209 Interrelationships Between the Key Elements of the Vitamin D Endocrine System: 25-OH-D 3 -1-Hydroxylase, Serum Calcium and Phosphorus Levels, Intestinal 1,25(OH) 2 D 3 , and Intestinal Calcium Binding Protein....Pages 211-231 Influence of Phosphate Depletion on the Biosynthesis and Circulating Level of 1α,25-Dihydroxyvitamin D....Pages 233-250 The Regulation of Vitamin D Metabolism....Pages 251-261 Front Matter....Pages 263-263 Phosphate Transport by Isolated Renal and Intestinal Plasma Membranes....Pages 265-277 Diphosphonates Mode of Action and Clinical Applications....Pages 279-289 Mechanism of Renal Action of Parathyroid Hormone....Pages 291-299 Metabolic Acidosis in Hyperparathyroidism Role of Phosphate Depletion and Other Factors....Pages 301-307 Idiopathic Hypercalciuria....Pages 309-317 Is There a Bone-Kidney Link in the Homeostasis of Inorganic Phosphate (Pi)?....Pages 319-322 Effect of Vitamin D 3 and 1,25-Dihydroxyvitamin D 3 on Intestinal Transport of Phosphate....Pages 323-332 Sodium-Dependent Transport of Orthophosphate in Nerve Fibres....Pages 333-344 Occurrence of Hyperparathyroidism in Children with X-Linked Hypophosphatemia under Treatment with Vitamin D and Phosphate....Pages 345-351 A Possible Relationship Between High-Extraction Cereal and Rickets and Osteomalacia....Pages 353-362 Inhibition of Parathyroid Hormone Secretion by Isoproterenol....Pages 363-368 Effect of Parathyroid Hormone and Volume Expansion on Jejunal Calcium, Sodium, and Water Transport in the Rat....Pages 369-377 Cholecalciferol Metabolites Binding in Porcine Parathyroid Glands....Pages 379-384 Effect of a Ca 2+ dependent protein kinase and a protein phosphatase on the Ca 2+ -phosphate transport ATPase....Pages 385-394 Influence of Vitamin D on Bicarbonate Reabsorption....Pages 395-404 Front Matter....Pages 263-263 Partial Body Phosphorus by Neutron Activation Analysis and Its Clinical Application....Pages 405-413 The Intestinal Absorption of Phosphate in Normal Human Subjects....Pages 415-421 Effect of the Diphosphonate EHDP on Plasma Inorganic Phosphate and Hemoglobin Oxygen Affinity of Diabetic and Healthy Subjects....Pages 423-430 The Action of 1αhydroxy Vitamin D 3 and Phosphate Supplements in Hypophosphataemic Osteomalacia....Pages 431-440 25-Hydroxycholecalciferol: High Affinity Substrate for Hepatic Cytochrome P-450....Pages 441-453 Renal Function in Treated Hypoparathyroidism a Possible Direct Nephrotoxic Effect of Vitamin D....Pages 455-464 Front Matter....Pages 465-465 The Role of Phosphate and Other Factors on the Pathogenesis of Renal Osteodystrophy....Pages 467-475 Ultrastructural Aspects of Bone Mineralization in Renal Osteodystrophy....Pages 477-491 Renal Osteodystrophy Studies with Scanning and Transmission Electron Microscopy....Pages 493-505 Controversies Regarding Intestinal Phosphate Transport and Absorption....Pages 507-513 Skeletal Growth in Uremia....Pages 515-531 The Management of Renal Osteodystrophy....Pages 533-547 Intestinal Phosphate Absorption in Normal and Uremic Man: Effects of 1,25(OH) 2 -Vitamin D 3 and 1α(OH)-Vitamin D 3 ....Pages 549-557 The Effect of Plasma Phosphate on the Action of 1αOHD 3 in Haemodialysis Patients....Pages 559-569 Evidence for a Relationship between Plasma Immunoreactive Calcitonin and Bone Disease in chronic Renal Failure....Pages 571-579 Hypophosphataemia and Osteomalacia in Haemodialysis Patients Not Taking Phosphate Binders....Pages 581-590 Effects of 25-Hydroxycholecalciferol on Calcium Metabolism in Chronic Renal Failure....Pages 591-601 Bone Disease, Hypophosphatemia and Hyperparathyroidism After Renal Transplantation....Pages 603-610 Scintigraphic Skeletal Changes in Dialysis and Kidney Transplanted Patients....Pages 611-619 Back Matter....Pages 621-636 We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appropriate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S.G.M.) suggested the thought to a group of scientists gathered for a luncheon in one of the attractive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Organizing Committee, therefore, decided to continue with the tradition to hold additional Workshops annually or every other year. The Third Workshop on Phosphate and other Minerals will be held in Madrid during July 13-15, 1977 and will be hosted by Dr. Aurelio Rapado. The theme of the future Workshops will continue to focus on the pathophysiology of phosphate homeostasis and the metabolism of other minerals. As such, the Workshops are of interest to nephrologists, endocrinologists, metabolites, hormone researchers, bone scientists and all others who have interest in mineral metabolism. The enthusiasm and interest noticed during the previous Workshops generated the thought that the publication of a journal dealing with mineral and electrolyte metabolism is timely and needed. Plans have been made to publish such a journal with the title "Mineral and Electrolyte Metabolism," by S. Karger, Basel, Switzerland under the Editorship of Dr. Shaul G. Massry with Drs. Louis V. Avioli and Eberhard Ritz as Associate Editors. An Editorial Board of 40 distinguished scientists has been appointed and the first issue of the Journal will appear in January 1978.