Phosphate and Minerals in Health and Disease (Advances in Experimental Medicine and Biology, 128)

We are pleased to present to our readers the Proceedings of the Fourth International Workshop on Phosphate and Other Minerals which was held in Strasbourg during June 22-24, 1979. It was hosted by Professor Henri Jahn, Professor of Medicine and Chief, Department of Nephrology at the University of Strasbourg. These Workshops have become a tradition in the scientific scene of mineral metabolism. The meetings have been providing a unique framework for close interaction between scientists from various disciplines, such as nephrologists, endocrinologists, bio­ chemists, nutritionists, and those dealing with bone metabolism. The Workshops also created a forum for the delivery of original information, as well as state-of-the-art presentations on exciting topics of current interest in this evergrowing field of phosphate and mineral homeostasis. The Fourth International Workshop was attended by three­ hundred scientists from 15 countries including Austria, Canada, Denmark, England, France, Germany, Holland, Israel, Italy, Japan, Sweden, Switzerland and the United States of America. The topics discussed included those dealing with the renal handling of phos­ phate, calcium and magnesium, intermediary phosphate metabolism and phosphate homeostasis in health and disease. Two symposia were also presented: one dealt with nephrolithiasis and its rela­ tion to phosphate and the other with bone metabolism. In addition to 22 presentations by invited speakers, the Workshop provided 46 oral and 93 poster presentations selected from over 250 abstracts submitted to the Organizing Committee. Front Matter....Pages i-xv Front Matter....Pages 1-1 The Control of Phosphate Uptake by the Isolated Renal Tubule....Pages 3-9 Sodium-Dependent Transport of Inorganic Phosphate Across the Renal Brush Border Membrane....Pages 11-23 Phosphate Transport in Isolated and Perfused Renal Tubules....Pages 25-35 Calcium Transport in the Pars Recta and the Loop of Henle....Pages 37-40 Renal Magnesium Transport and the Effects of Hypermagnesemia, Hypercalcemia, Body Magnesium Stores and Parathyroid Hormone....Pages 41-49 The Interrelationship Between Phosphate and Magnesium Metabolism....Pages 51-66 PO 4 Transport in Superficial and Juxtamedullary Nephrons in the Cat: Evidence for Nephron Heterogeneity....Pages 67-68 Adaptive Changes in Renal Cortical Brush Border Membrane....Pages 69-76 Micropuncture Study of Distal Tubular Activation of Phosphate Reabsorption in the Rat....Pages 77-82 The Influence of D-Glucose on Phosphate Absorption in the Rat Proximal Tubule....Pages 83-88 Tubular Localization of the Effect of 1,25-Dihydroxy-Vitamin D 3 and Dietary Phosphate on the Transport of Phosphate in Thyroparathyroidectomized Rats....Pages 89-91 Natriuresis and Phosphaturia during Extracellular Volume Expansion, Blood Volume Expansion or Stimulation of the Intrathoracic Volume Receptors....Pages 93-105 Adaptation of Tubular Phosphate Transport: Relation between Phosphate Requirement, as Influenced by Growth, and Supply....Pages 107-111 Indirect Effect of Hypercapnia on the Phosphaturia of Respiratory Acidosis....Pages 113-115 Phosphate Handling by the Remnant Dog Kidney in the Presence and Absence of the Contralateral Normal Kidney....Pages 117-124 Phosphate Transport in the Rabbit Cortical Collecting Tubule....Pages 125-127 Additivity of the Phosphaturic Action of Parathyrin and Calcitonin in the Rat Kidney....Pages 129-134 The Effect of Bicarbonate on Anion Reabsorption Along the Dog Nephron....Pages 135-143 The Phosphaturic Action of PTH in the Steady State in Patients with Normal and Impaired Renal Function....Pages 145-154 Mechanism of the Phosphaturia due to Chlorothiazide....Pages 155-157 Front Matter....Pages 1-1 Effect of Unilateral Nephrectomy and its Accompanying Hemodynamic Changes on Calcium and Phosphate Excretion in the Dog....Pages 159-166 Effect of Metabolic Acidosis and Alkalosis on the Renal Response to Parathyroid Hormone Infusion in Normal Man....Pages 167-172 Front Matter....Pages 173-173 Phosphate Metabolic Control of Potassium Movement — Its Effect on Osmotic Pressure of the Cell....Pages 175-186 Phosphate and Acid-Base Homeostasis....Pages 187-196 Phosphate, Calcium and Lipid Metabolism....Pages 197-208 Protective Effect of Phosphate Restriction on Renal Function....Pages 209-218 Pharmacology of Disodium (3-Amino-1-Hydroxypropylidene)-1, 1-Bisphosphonate....Pages 219-227 Effect of Phosphate on the Arginine-Induced Insulin Release by the Isolated Perfused Rat Pancreas....Pages 229-237 Response of Red Cell Phosphate to Acute and Chronic Changes in Plasma Phosphate in Man....Pages 239-248 Chronic Hypophosphatemia in Kidney Transplanted Children and Young Adults....Pages 249-254 Pathogenesis of Hypophosphatemia in Kidney Necrograft Recipients: A Controlled Trial....Pages 255-261 Effect of Acute Metabolic Acidosis on Plasma Phosphorus Concentration....Pages 263-279 Calcium Carbonate-Induced Effects on Serum Ca X P Product and Serum Creatinine in Renal Failure: A Retrospective Study....Pages 281-287 Divalent Ions in Blood and Cerebrospinal Fluid: Effect of Hypercalcemia, Hyperphosphatemia, Renal Failure and Parathyroid Hormone....Pages 289-297 Effects of Disodium Dichloromethylene Diphosphonate (Cl 2 MDP) on Paget’s Disease of Bone....Pages 299-309 Front Matter....Pages 311-311 Function of the Sarcoplasmic Reticulum (SR) in Hypophosphatemic Myopathy....Pages 313-321 Selective Phosphorus Deficiency in the Hyperalimented Hypophosphatemic Dog and Phosphorylation Potentials in the Muscle Cell....Pages 323-334 Effects of Severe Phosphate Deprivation in Growing Chicks and Possible Role of Vitamin D....Pages 335-341 Abnormalities of Glycogen Metabolism in Cardiomyopathy of Phosphorous Depletion....Pages 343-350 Altered Vitamin D, Cyclic Nucleotide and Trace Mineral Metabolism in the X-Linked Hypophosphatemic Mouse....Pages 351-359 Front Matter....Pages 311-311 Cation Effects on Phosphate Homeostasis in Hypophosphatemic Subjects....Pages 361-368 Front Matter....Pages 369-369 Transmucosal 45 Ca-Flux and Ca-ATPase Specific Activity in Basolateral Plasma Membranes of the Small Intestinal Mucosa in Response to Diuretics....Pages 371-379 Intestinal Phosphate Transport....Pages 381-390 Gut Absorption of Calcium: Interactions between Phosphate and Vitamin D....Pages 391-397 Characterization of Phosphate Uptake in Isolated Chick Intestinal Cells....Pages 399-404 Role of Phosphate in the Resistance to Intestinal Effects of Parathyroid Hormone in Rats with Chronic Renal Failure....Pages 405-416 Metabolic Studies of the Cytosolic Calcium-Binding Protein of the Rat....Pages 417-424 Front Matter....Pages 425-425 Is there a Disorder of Phosphate Metabolism in Idiopathic Hypercalciuria?....Pages 427-437 Hyperuricosuric Calcium Oxalate Nephrolithiasis....Pages 439-450 A Critical Evaluation of Treatment of Calcium Stones....Pages 451-465 Increased Incidence of Nephrolithiasis (N) in Lifeguards (LG) in Israel....Pages 467-472 Urolithiasis Research: Progress and Trends....Pages 473-481 Front Matter....Pages 483-483 The Uptake of Immunoreactive Parathyroid Hormone by Peripheral Organs....Pages 485-494 Effect of Acute Ethanol Loading on Parathyroid Gland Secretion in the Rat....Pages 495-504 Effects of Cimetidine on Parathyroid Hormone in Chronic Uremia....Pages 505-514 Parathyroid Hormone Dependent Hypercalciuria in Chronic Metabolic Acidosis....Pages 515-522 The Parathyroid Hormone Receptor-Adenylate Cyclase System in Chicken Kidney....Pages 523-536 Renal Receptors for Parathyroid Hormone in Normal, Parathyroidectomized and Vitamin D-Deficient Rats....Pages 537-545 Front Matter....Pages 547-547 What Is Osteomalacia?....Pages 549-562 Mechanisms of Calcification....Pages 563-577 Front Matter....Pages 547-547 Interactions of Hormones, Ions, and Drugs in the Regulation of Osteoclastic Bone Resorption....Pages 579-596 Recent Advances in Management of Osteoporosis....Pages 597-613 The Role of Vitamin D Metabolites in the Management of Bone Abnormalities in Renal Disease....Pages 615-624 Antagonistic Effects of 25(OH)Vitamin D 3 and Peptide Hormones on the Activation of Adenylate Cyclase/Cyclic AMP System in Renal Tissue in Vitro....Pages 625-633 Effect of Uremic Sera on Parathyroid Hormone (PTH) Mediated Release of Calcium from Normal Rat Embryonal Bone Maintained in Tissue Culture....Pages 635-643 Multivariate Analysis of the Vitamin D Endocrine System: Evidence for the Essentiality of both 24R,25-Dihydroxyvitamin D 3 and 1α,25-Dihydroxyvitamin D 3 ....Pages 645-659 Back Matter....Pages 661-675 We are pleased to present to our readers the Proceedings of the Fourth International Workshop on Phosphate and Other Minerals which was held in Strasbourg during June 22-24, 1979. It was hosted by Professor Henri Jahn, Professor of Medicine and Chief, Department of Nephrology at the University of Strasbourg. These Workshops have become a tradition in the scientific scene of mineral metabolism. The meetings have been providing a unique framework for close interaction between scientists from various disciplines, such as nephrologists, endocrinologists, biochemists, nutritionists, and those dealing with bone metabolism. The Workshops also created a forum for the delivery of original information, as well as state-of-the-art presentations on exciting topics of current interest in this ever-growing field of phosphate and mineral homeostasis. The Fourth International Workshop was attended by three hundred scientists from 15 countries including Austria, Canada, Denmark, England, France, Germany, Holland, Israel, Italy, Japan, Sweden, Switzerland and the United States of America. The topics discussed included those dealing with the renal handling of phosphate, calcium and magnesium, intermediary phosphate metabolism and phosphate homeostasis in health and disease. Two symposia were also presented: one dealt with nephrolithiasis and its relation to phosphate and the other with bone metabolism. In addition to 22 presentations by invited speakers, the Workshop provided 46 oral and 93 poster presentations selected from over 250 abstracts submitted to the Organizing Committee. The Fifth International Workshop on Phosphate and Other Minerals will be held during September 24-27, 1981 in New York City, U.S.A. It will be hosted by Dr. Joseph Letteri, Chief, Division of Nephrology, Nassau County Medical Center and Professor of Medicine at the State University of New York at Stoney Brook. The theme of this coming Workshop will continue to focus on the pathophysiology of phosphate homeostasis and the metabolism of other minerals