Phencyclidine An Update

Table of Contents......Page 12 Foreword......Page 6 Preface......Page 8 Characterization of Phencyclidine and Sigma Receptor-Binding Sites in Brain......Page 14 Further Evidence of Phencyclidine/Sigma Opioid Receptor Commonality......Page 27 Isolation and Identification of an Endogenous Ligand for the Phencyclidine Receptor......Page 37 Phencyclidine (PCP) Selectively Blocks Certain Presynapt Potassium Channels......Page 50 Involvement of Dopaminergic, Cholinergic, and Glutamatergic Mechanisms in the Actions of Phencyclidine-Like Drugs......Page 65 Anticonvulsant Properties of Phencyclidine and Ketamine......Page 80 Agonistic and Antagonistic Effects of PCP-Derivatives and Sigma Opioids in PCP Behavioral and Receptor Assays......Page 93 Electroencephalographic (EEG), Psychopharmacological, and Receptor-Binding Profiles of 'Phencyclinoids'......Page 107 Modulation of Phencyclidine (PCP) Pharmacokinetics With PCP-Specific Fab Fragments......Page 125 Psychopharmacology of Phencyclidine......Page 140 Discriminative Stimulus Properties of PCP Mimetics......Page 147 Clinical Implications of Behavioral Pharmacology Research on Phencyclidine......Page 161 Phencyclidine: Changing Abuse Patterns......Page 176 PCP and Crime: Just Another Illicit Drug?......Page 187 Neuropsychological Assessment of Phencyclidine Abusers......Page 203 Phencyclidine Intoxication......Page 222 Diagnosis and Treatment of Chronic Phencyclidine (PCP) Abuse......Page 231 Legal Issues Associated With PCP Abuse--The Role of the Forensic Expert......Page 242 The Long-Term Effects on Neurodevelopment in Infants Exposed Prenatally to PCP......Page 250 Clinical Observations in the Treatment of Adolescent and Young Adult PCP Abusers......Page 265 List of NIDA Research Monographs......Page 274