Pharmacotherapies for the treatment of opioid dependence : efficacy, cost-effectiveness, and implementation guidelines

The most comprehensive text of its kind, this book addresses both the management of opioid withdrawal and opioid maintenance therapy, and combines up-to-date reviews of the scientific literature with evidence-based clinical guidelines for all of the relevant pharmacotherapies. A unique work, Pharmacotherapies for the Treatment of Opioid Dependence presents: · detailed information on the cost-effectiveness of the various types of opioid treatment · the range of pharmacotherapies used for the management of opioid dependence · the state of knowledge from the international research literature on the value and relative efficacy of the various pharmacological approaches. This includes pharmacotherapies used in the management of withdrawal from opioids such as clonidine, lofexidine, methadone, buprenorphine and naltrexone and also symptomatic medications. It also includes different forms of maintenance therapy using opioid agonists such as methadone, LAAM, buprenorphine, slow-release oral morphine and diamorphine, and opioid antagonists such as naltrexone. This text should appeal to researchers, to identify gaps in the research literature and provide a basis for determining appropriate research directions, to clinicians by providing clinical with clinical guidelines and information concerning the empirical basis for the treatments, and to policy makers in assisting them to make decisions about the various treatments from a public health perspective, taking into account the relative cost and effectiveness of the interventions. Opioid dependence and management / Louisa Degenhardt, Richard P. Mattick, and Amy Gibson Pharmacology of opioid agonists and antagonists / Andrea L. Gordon ... [et al.] Services for heroin withdrawal : a review / Nicholas Lintzeris, Linda Gowing, and James Bell Methadone maintenance treatment / Jeff Ward, Wayne Hall, and Richard P. Mattick LAAM in the treatment of opioid dependence : a systematic review / Nicolas Clark, Alan Gijsbers, and Jason M. White The place of buprenorphine in the management of opioid dependence / Richard P. Mattick, Courtney Breen, and Amy Gibson Treating heroin dependence with diamorphine (pharmaceutical heroin) / Gabriele Bammer Naltrexone maintenance treatment / Amy Gibson and Alison Ritter Pharmacotherapies and pregnancy / Adrian Dunlop ... [et al.] Politics, practice, and research into treatment of heroin addiction / James Bell Clinical guidelines and procedures for the use of methadone in the maintenance treatment of opioid dependence / Sue Henry-Edwards ... [et al.] National clinical guidelines and procedures for the use of buprenorphine in the treatment of heroin dependence / Nicholas Lintzeris ... [et al.] Clinical guidelines and procedures for the use of naltrexone in the management of opioid dependence James Bell ... [et al.] Choosing treatments : the role of economics in informing future decisions / Marian Shanahan and Richard P Mattick.