Pharmacology of the Contraceptive Steroids

Reviews the pharmacology of contraceptive steroids providing analyses of the pharmacokinetics and intermediate metabolism of orally administered synthetic progestins and oestrogens and of steroids administered by long-acting injections and implants. Front Cover Title Page Copyright Contents Contributors Preface Introduction (Potts) 1: The Progestins (Perone) 2: The Estrogens (Goldzieher) 3: Mechanism of Action of Steroid Hormones (Clark) 4: Pharmacokinetics of Selected Contraceptive Steroids in Various Animal Species (Kuhnz & Blode) 5: Metabolism of Contraceptive Steroids in Animals (Stanczyk) 6: Issues in Animal Pharmacology (Edgren) 7: Pharmacokinetics and Metabolism of Progestins in Humans (Fotherby) 8: Pharmacokinetics and Metabolism of Ethynyl Estrogens (Goldzieher) 9: Long-Acting Contraceptives (Primiero & Benagiano) 10: The Hypothalamo-Pituitary-Ovarian System (Goldzieher) 11: The Female Breast (Beller) 12: The Lower Reproductive Tract (Johannisson & Brosens) 13: The Adrenal Gland (Petak & Steinberger) 14: The Thyroid Gland (Goldzieher) 15: The Liver (Sillem & Teichmann) 16: Bone (Notelovitz) 17: Effects on the Skin (Goldzieher) 18: Skeletal Muscle Function (Wirth) 19: Nervous System (Keefe) 20: Cardiovascular System: Blood Pressure (Fraser & Weir) 21: Cardiovascular System: Coagulation, Thrombosis, and Contraceptive Steroids—Is There A Link? (Beller) 22: Cardiovascular System: Contraceptive Steroids, Plasma Lipoprotein Levels, and Coronary Artery Atherosclerosis (Washburn, Wagner, Adams, & Clarkson) 23: Metabolism: Carbohydrate Metabolism (Elkind-Hirsch & Goldzieher) 24: Metabolism: Contraceptive Steroids and Some Plasma Proteins (Cullberg) 25: Metabolism: Vitamins and Trace Elements (Amatayakul) 26: Immunologic Effects of Estrogens, Progestins, and Estrogen-Progestin Combinations (Schuurs, Geurts, Goorissen, Hazes, & Verheul) 27: Teratogenesis and Mutagenesis (Goldzieher) 28: Drug Interactions (Back & Orme) 29: Evaluating Efficacy and Safety (Edelman & Goldzieher) Appendix: Chemical Nomenclature: Trivial and Chemical Names Subject Index Back Cover 15. The Liver / M.h. Sillem And A.t. Teichmann -- 16. Bone / Morris Notelovitz -- 17. Effects On The Skin / Joseph W. Goldzieher -- 18. Skeletal Muscle Function / John C. Wirth -- 19. Nervous System / David Keefe -- 20. Cardiovascular System: Blood Pressure / Robert Fraser And Ronald J. Weir -- 21. Cardiovascular System: Coagulation, Thrombosis, And Contraceptive Steroids -- Is There A Link? / Fritz K. Beller -- 22. Cardiovascular System: Contraceptive Steroids, Plasma Lipoprotein Levels, And Coronary Artery Atherosclerosis / Scott A. Washburn, Janice D. Wagner, Michael R. Adams And Thomas B. Clarkson -- 23. Metabolism: Carbohydrate Metabolism / Karen Elkind-hirsch And Joseph W. Goldzieher -- 24. Metabolism: Contraceptive Steroids And Some Plasma Proteins / Goran Cullberg -- 25. Metabolism: Vitamins And Trace Elements / Kosin Amatayakul. 26. Immunologic Effects Of Estrogens, Progestins, And Estrogen-progestin Combinations / A.h.w.m. Schuurs, T.b.p. Geurts, E.m. Goorissen, J.m.w. Hazes And H.a.m. Verheul -- 27. Teratogenesis And Mutagenesis / Joseph W. Goldzieher -- 28. Drug Interactions / D.j. Back And M. L'e. Orme -- 29. Evaluating Efficacy And Safety / David A. Edelman And Joseph W. Goldzieher -- Appendix. Chemical Nomenclature. Chief Editor, Joseph W. Goldzieher ; Associate Editor, Kenneth Fotherby. Includes Bibliographical References And Index.