Pharmacogenomics of Human Drug Transporters : Clinical Impacts

Sets the foundation for safer, more effective drug therapies With this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse drug reactions. Moreover, it sets the foundation for the development of drug therapies that are tailored to an individual patient's genetics. Pharmacogenomics of Human Drug Transporters serves as a comprehensive guide to how transporters regulate the absorption, distribution, and elimination of drugs in the body as well as how an individual's genome affects those processes. The book's eighteen chapters have been authored by a team of leading pioneers in the field. Based on their own laboratory and clinical experience as well as a thorough review of the literature, these authors explore all facets of drug transporter pharmacogenomics, including: Individual drug transporters and transporter families and their clinical significance Principles of altered drug transport in drug?drug interactions, pharmacotherapy, and personalized medicine Emerging new technologies for rapid detection of genetic polymorphisms Clinical aspects of genetic polymorphisms in major drug transporter genes Future research directions of drug transporter pharmacogenomics and the prospect of individualized medicine Pharmacogenomics of Human Drug Transporters opens the door to new drug discovery and development breakthroughs leading to safer and more effective customized drug therapies.The book is recommended for pharmaceutical scientists, biochemists, pharmacologists, clinicians, and genetics and genomics researchers.Content: Chapter 1 Introduction to Pharmacogenomics of Drug Transporters (pages 1–11): Marianne K. DeGorter and Richard B. Kim Chapter 2 ADME Pharmacogenomics in Drug Development (pages 13–37): Liangfu Chen and Joseph W. Polli Chapter 3 Regulatory Perspective on Pharmacogenomics of Drug?Metabolizing Enzymes and Transporters (pages 39–71): Lei Zhang, Gilbert J. Burckart, Lawrence J. Lesko and Shiew?Mei Huang Chapter 4 The Pharmacogenomics of Membrane Transporters Project (pages 73–108): Sook Wah Yee, Deanna L. Kroetz and Kathleen M. Giacomini Chapter 5 Emerging New Technology of SNP Typing (pages 109–124): Toshihisa Ishikawa and Yoshihide Hayashizaki Chapter 6 OATP1A2, OAT1, and OAT3 (pages 125–139): Rommel G. Tirona Chapter 7 OATP1B1, OATP1B3, and OATP2B1 (pages 141–169): Jorg Konig and Martin F. Fromm Chapter 8 OCT (SLC22A) and OCTN Family (pages 171–208): Sophie L. Stocker, Arian Emami Riedmaier, Matthias Schwab and Kathleen M. Giacomini Chapter 9 MATE (SLC47) Family (pages 209–222): Atsushi Yonezawa and Ken?ichi Inui Chapter 10 PEPT (SLC15A) Family (pages 223–242): Tomoko Sugiura, Saki Umeda, Akira Tsuji and Yukio Kato Chapter 11 Nucleoside Transporters (SLC28 and SLC29) Family (pages 243–270): Miriam Molina?Arcas and Marcal Pastor?Anglada Chapter 12 P?glycoprotein (MDR1/ABCB1) (pages 271–293): Ingolf Cascorbi Chapter 13 BSEP (ABCB11) (pages 295–309): Bruno Stieger and Gerd A. Kullak?Ublick Chapter 14 BCRP (ABCG2) (pages 311–343): Agnes Basseville, Susan E. Bates, William D. Figg and Alex Sparreboom Chapter 15 MRP2 (ABCC2) and MRP3 (ABCC3) (pages 345–364): Anne T. Nies Chapter 16 MRP4 (ABCC4) (pages 365–385): Satish B. Cheepala, Mugdha Sukthankar and John D. Schuetz Chapter 17 MRP8 (ABCC11) (pages 387–400): Yu Toyoda and Toshihisa Ishikawa Chapter 18 Future Perspectives (pages 401–416): Toshihisa Ishikawa and Joseph Ware **Sets the foundation for safer, more effective drug therapies** With this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse drug reactions. Moreover, it sets the foundation for the development of drug therapies that are tailored to an individual patient's genetics. __Pharmacogenomics of Human Drug Transporters__ serves as a comprehensive guide to how transporters regulate the absorption, distribution, and elimination of drugs in the body as well as how an individual's genome affects those processes. The book's eighteen chapters have been authored by a team of leading pioneers in the field. Based on their own laboratory and clinical experience as well as a thorough review of the literature, these authors explore all facets of drug transporter pharmacogenomics, including: * Individual drug transporters and transporter families and their clinical significance * Principles of altered drug transport in drug?drug interactions, pharmacotherapy, and personalized medicine * Emerging new technologies for rapid detection of genetic polymorphisms * Clinical aspects of genetic polymorphisms in major drug transporter genes * Future research directions of drug transporter pharmacogenomics and the prospect of individualized medicine __Pharmacogenomics of Human Drug Transporters__ opens the door to new drug discovery and development breakthroughs leading to safer and more effective customized drug therapies.The book is recommended for pharmaceutical scientists, biochemists, pharmacologists, clinicians, and genetics and genomics researchers.Content: Chapter 1 Introduction to Pharmacogenomics of Drug Transporters (pages 1–11): Marianne K. DeGorter and Richard B. KimChapter 2 ADME Pharmacogenomics in Drug Development (pages 13–37): Liangfu Chen and Joseph W. PolliChapter 3 Regulatory Perspective on Pharmacogenomics of Drug?Metabolizing Enzymes and Transporters (pages 39–71): Lei Zhang, Gilbert J. Burckart, Lawrence J. Lesko and Shiew?Mei HuangChapter 4 The Pharmacogenomics of Membrane Transporters Project (pages 73–108): Sook Wah Yee, Deanna L. Kroetz and Kathleen M. GiacominiChapter 5 Emerging New Technology of SNP Typing (pages 109–124): Toshihisa Ishikawa and Yoshihide HayashizakiChapter 6 OATP1A2, OAT1, and OAT3 (pages 125–139): Rommel G. TironaChapter 7 OATP1B1, OATP1B3, and OATP2B1 (pages 141–169): Jorg Konig and Martin F. FrommChapter 8 OCT (SLC22A) and OCTN Family (pages 171–208): Sophie L. Stocker, Arian Emami Riedmaier, Matthias Schwab and Kathleen M. GiacominiChapter 9 MATE (SLC47) Family (pages 209–222): Atsushi Yonezawa and Ken?ichi InuiChapter 10 PEPT (SLC15A) Family (pages 223–242): Tomoko Sugiura, Saki Umeda, Akira Tsuji and Yukio KatoChapter 11 Nucleoside Transporters (SLC28 and SLC29) Family (pages 243–270): Miriam Molina?Arcas and Marcal Pastor?AngladaChapter 12 P?glycoprotein (MDR1/ABCB1) (pages 271–293): Ingolf CascorbiChapter 13 BSEP (ABCB11) (pages 295–309): Bruno Stieger and Gerd A. Kullak?UblickChapter 14 BCRP (ABCG2) (pages 311–343): Agnes Basseville, Susan E. Bates, William D. Figg and Alex SparreboomChapter 15 MRP2 (ABCC2) and MRP3 (ABCC3) (pages 345–364): Anne T. NiesChapter 16 MRP4 (ABCC4) (pages 365–385): Satish B. Cheepala, Mugdha Sukthankar and John D. SchuetzChapter 17 MRP8 (ABCC11) (pages 387–400): Yu Toyoda and Toshihisa IshikawaChapter 18 Future Perspectives (pages 401–416): Toshihisa Ishikawa and Joseph Ware Introduction to pharmacogenomics of drug transporters / Marianne K DeGorter and Richard B Kim -- ADME pharmacogenomics in drug development / Liangfu Chen and Joseph W. Polli -- Regulatory perspective on pharmacogenomics of drug metabolizing enzymes and transporters / Lei Zhang [and others] -- The pharmacogenomics of membrane transporters project / Sook Wah Yee, Deanna L. Kroetz, Kathleen M. Giacomini -- Emerging new technology of SNP typing / Toshihisa Ishikawa and Yoshihide Hayashizaki -- Chapters 6: OATP1A2, OAT1 and OAT3 / Rommel G. Tirona -- OATP1B1, OATB1B3 and OATP2B1 / Jorg Konig and Martin Fromm -- OCT (SLC22A) and OCTN families / Sophie L. Stocker [and others] -- MATE (SLC47) family / Atsushi Yonezawa and Ken-ichi Inui -- PEPT (SLC15A) family / Tomoko Sugiura [and others] -- Nucleoside transporters (SLC28 and SLC29) family / Míriam Molina-Arcas -- Maral pastor-anglada -- P-glycoprotein (MDR1/ABCB1) / Ingolf Cascorbi -- Bile salt export pump BSEP (ABCB11) : role in liver physiology and liver disease / Gerd Ullak-Kublick and Bruno Stieger -- BCRP (ABCG2) / Agnes Basseville [and others] -- MRP2 (ABCC2) and MRP3 (ABCC3) / Anne T. Nies -- MRP4 (ABCC4) / Satish B. Cheepala, Mugdha Sukthankar, John D. Schuetz -- MRP8 (ABCC11) / Yu Toyoda, Toshihisa Ishikawa -- Future perspectives / Toshihisa Ishikawa, Joseph Ware Highlighting the internationally hot topic of pharmacogenomics and its influence on drug therapy, Pharmacogenomics of Human Drug Transporters reviews individual drug transporters, including specific transporter families and clinical implications. This book serves as a comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body, and the reasons why individuals differ. The authors include sufficient detail to enable non-specialists to understand the principles and techniques and provides a practical, hands-on resource for rese