Pharmacogenomics in Clinical Therapeutics: Dasgupta/Pharmacogenomics in Clinical Therapeutics

Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics represents a real advance on traditional therapeutic drug monitoring. Pharmacogenomics in Clinical Therapeutics provides an introduction to the principles of pharmacogenomics before addressing the pharmacogenomic aspects of key therapeutic areas such as warfarin therapy, cancer chemotherapy, therapy with immunosuppressants, antiretroviral therapy, and psychoactive drugs. It also includes methods of pharmacogenomic testing and the pharmacogenomic aspects of drug–drug interactions. From a team of expert contributors, Pharmacogenomics in Clinical Therapeutics is a comprehensive overview of the current state of pharmacogenomics in pharmacotherapy for all clinicians, pharmacologists and clinical laboratory professionals. It is also a guide for practicing clinicians and health care professionals to the basic principles of pharmacogenomics, laboratory tests currently available to aid clinicians, and the future promise of this developing field.Content: Chapter 1 Pharmacogenomics Principles: Introduction to Personalized Medicine (pages 1–14): Parvaz Madadi and Gideon Koren Chapter 2 Traditional Therapeutic Drug Monitoring and Pharmacogenomics: Are They Complementary? (pages 15–25): Christine L. H. Snozek, Loralie J. Langman and Amitava Dasgupta Chapter 3 Pharmacogenomics Aspect of Warfarin Therapy (pages 26–38): Matthew D. Krasowski Chapter 4 Pharmacogenetics and Cancer Chemotherapy (pages 39–52): Christine L. H. Snozek Chapter 5 Pharmacogenomic Considerations in Anesthesia and Pain Management (pages 53–69): Christine M. Formea and Wayne T. Nicholson Chapter 6 Pharmacogenomics of Immunosuppressants (pages 70–97): Nicolas Picard and Pierre Marquet Chapter 7 Pharmacogenomics of Cardiovascular Drugs (pages 98–126): Linnea M. Baudhuin Chapter 8 Pharmacogenomic Aspects of Antiretroviral Therapy (pages 127–143): Natella Y. Rakhmanina and John N. van den Anker Chapter 9 Pharmacogenetics of Psychoactive Drugs (pages 144–175): Jorge L. Sepulveda Chapter 10 Pharmacogenomic Aspects of Adverse Drug–Drug Interactions (pages 176–184): Loralie J. Langman and Christine L. H. Snozek Chapter 11 Microarray Technology and Other Methods in Pharmacogenomics Testing (pages 185–200): Jorge L. Sepulveda Chapter 12 Pharmacogenetic Testing in the Clinical Laboratory Environment (pages 201–223): Mark P. Borgman and Mark W. Linder Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics represents a real advance on traditional therapeutic drug monitoring. __Pharmacogenomics in Clinical Therapeutics__ provides an introduction to the principles of pharmacogenomics before addressing the pharmacogenomic aspects of key therapeutic areas such as warfarin therapy, cancer chemotherapy, therapy with immunosuppressants, antiretroviral therapy, and psychoactive drugs. It also includes methods of pharmacogenomic testing and the pharmacogenomic aspects of drug–drug interactions. From a team of expert contributors, __Pharmacogenomics in Clinical Therapeutics__ is a comprehensive overview of the current state of pharmacogenomics in pharmacotherapy for all clinicians, pharmacologists and clinical laboratory professionals. It is also a guide for practicing clinicians and health care professionals to the basic principles of pharmacogenomics, laboratory tests currently available to aid clinicians, and the future promise of this developing field.Content: Chapter 1 Pharmacogenomics Principles: Introduction to Personalized Medicine (pages 1–14): Parvaz Madadi and Gideon KorenChapter 2 Traditional Therapeutic Drug Monitoring and Pharmacogenomics: Are They Complementary? (pages 15–25): Christine L. H. Snozek, Loralie J. Langman and Amitava DasguptaChapter 3 Pharmacogenomics Aspect of Warfarin Therapy (pages 26–38): Matthew D. KrasowskiChapter 4 Pharmacogenetics and Cancer Chemotherapy (pages 39–52): Christine L. H. SnozekChapter 5 Pharmacogenomic Considerations in Anesthesia and Pain Management (pages 53–69): Christine M. Formea and Wayne T. NicholsonChapter 6 Pharmacogenomics of Immunosuppressants (pages 70–97): Nicolas Picard and Pierre MarquetChapter 7 Pharmacogenomics of Cardiovascular Drugs (pages 98–126): Linnea M. BaudhuinChapter 8 Pharmacogenomic Aspects of Antiretroviral Therapy (pages 127–143): Natella Y. Rakhmanina and John N. van den AnkerChapter 9 Pharmacogenetics of Psychoactive Drugs (pages 144–175): Jorge L. SepulvedaChapter 10 Pharmacogenomic Aspects of Adverse Drug–Drug Interactions (pages 176–184): Loralie J. Langman and Christine L. H. SnozekChapter 11 Microarray Technology and Other Methods in Pharmacogenomics Testing (pages 185–200): Jorge L. SepulvedaChapter 12 Pharmacogenetic Testing in the Clinical Laboratory Environment (pages 201–223): Mark P. Borgman and Mark W. Linder Pharmacogenomics Principles : Introduction To Personalized Medicine / Parvaz Madadi, And Gideon Koren -- Traditional Therapeutic Drug Monitoring And Pharmacogenomics : Are They Complementary? / Christine Snozek, Loralie J. Langman, And Amitava Dasgupta -- Pharmacogenomics Aspect Of Warfarin Therapy / Matthew D. Krasowski -- Pharmacogenetics And Cancer Chemotherapy / Christine L.h. Snozek -- Pharmacogenomic Considerations In Anesthesia And Pain Management / Christine Formea, Wayne T. Nicholson -- Pharmacogenomics Of Immunosuppressants / Nicolas Picard And Pierre Marquet -- Pharmacogenomics Of Cardiovascular Drugs / Linnea M. Baudhuin -- Pharmacogenomics Aspect Of Antiretroviral Therapy / Natella Y. Rakhmanina And John N. Van Den Anker -- Pharmacogenetics Of Psychoactive Drugs / Jorge L. Sepulveda -- Pharmacogenomic Aspects Of Adverse Drug-drug Interactions / Loralie J. Langman And Christine Snozek -- Microarray Technology And Other Methods In Pharmacogenomics Testing / Jorge L. Sepulveda -- Pharmacogenetic Testing In The Clinical Laboratory Environment / Mark P. Borgman And Mark W. Linder. Edited By Loralie J. Langman, Amitava Dasgupta. Includes Bibliographical References And Index. Front Matter -- Pharmacogenomics Principles: Introduction to Personalized Medicine / Parvaz Madadi, Gideon Koren -- Traditional Therapeutic Drug Monitoring and Pharmacogenomics: Are They Complementary? / Christine L H Snozek, Loralie J Langman, Amitava Dasgupta -- Pharmacogenomics Aspect of Warfarin Therapy / Matthew D Krasowski -- Pharmacogenetics and Cancer Chemotherapy / Christine L H Snozek -- Pharmacogenomic Considerations in Anesthesia and Pain Management / Christine M Formea, Wayne T Nicholson -- Pharmacogenomics of Immunosuppressants / Nicolas Picard, Pierre Marquet -- Pharmacogenomics of Cardiovascular Drugs / Linnea M Baudhuin -- Pharmacogenomic Aspects of Antiretroviral Therapy / Natella Y Rakhmanina, John N van den Anker -- Pharmacogenetics of Psychoactive Drugs / Jorge L Sepulveda -- Pharmacogenomic Aspects of Adverse Drug-Drug Interactions / Loralie J Langman, Christine L H Snozek -- Microarray Technology and Other Methods in Pharmacogenomics Testing / Jorge L Sepulveda -- Pharmacogenetic Testing in the Clinical Laboratory Environment / Mark P Borgman, Mark W Linder -- Index Pharmacogenomics is the process of analyzing patients' genes to predict the onset of adverse reactions or forecast the effectiveness of therapeutic drugs. This useful text is written to discuss both the theory and the clinical application of the principles of pharmacogenomics. Current research has clearly established that a range of treatments may be greatly improved through genetic profiling of individual patients before certain therapies begin. Aimed at clinicians, pharmacologists, and clinical laboratory professionals this book discusses the important role of laboratory tests in the practice of personalized medicine. An important new book, Pharmacogenomics in Clinical Therapeutics serves as a guide to the basic principles of pharmacogenomics in a range of common therapeutic areas and as the basis of the personalized medicine of the future Contributors from pharmacology, pathology, and other medical specialties explore the potential to personalize drugs using information from the genome. Readers are not expected to have a background in pharmacogenomics, but those who do will be able to use the book as a quick reference. Among the topics are whether traditional therapeutic drug monitoring and pharmacogenomics are complementary, pharmacogenomic aspects of warfarin therapy, pharmacogenomic considerations in anesthesia and pain management, anti-retroviral therapy, psychoactive drugs, and microarray technology and other methods in pharmacogenomics testing. Annotation ©2012 Book News, Inc., Portland, OR (booknews.com)